2 completed, 1 active not recruiting, 1 withdrawn. 2 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Active not recruiting 1, Completed 1 |
| Phase 1 | 1 | Active not recruiting 1 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Thymidine Kinase 2 Deficiency: new trials by email Literature Review of Thymidine Kinase 2 Deficiency trials Research Report on Thymidine Kinase 2 Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) MT1621 - Thymidine Kinase 2 Deficiency | Phase 3 | Withdrawn | Zogenix MDS, Inc. | 2022-09-30 | 2023-09-01 | |
| A Retrospective Study of Subjects With Thymidine Kinase 2 Deficiency Observational retrospective data - Thymidine Kinase 2 Deficiency | Completed | Zogenix MDS, Inc. | 61 | 2021-07-23 | 2023-09-01 | |
| An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency doxecitine and doxribtimine - Thymidine Kinase 2 Deficiency | Phase 2 | Completed | UCB BIOSCIENCES, Inc. | 47 | 2019-07-05 | 2026-09-08 |
| Treatment of TK2 Deficiency With Thymidine and Deoxycytidine Thymidine - Mitochondrial DNA Depletion Syndrome 2 Myopathic Type, Thymidine Kinase 2 Deficiency | Phase 1 / Phase 2 | Active not recruiting | Columbia University | 23 | 2017-05-16 | 2026-01-28 |
Mitochondrial Diseases (3) · Muscle Weakness (3) · Muscular Atrophy (3)
Atrophy (3) · Metabolic Diseases (3) · Muscular Diseases (3) · Musculoskeletal Diseases (3) · Nervous System Diseases (3) · Neurologic Manifestations (3) · Neuromuscular Manifestations (3) · Nutritional and Metabolic Diseases (3) · Pathologic Processes (3) · Pathological Conditions, Anatomical (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3)
Deoxycytidine (3) · Thymidine (3)
Zogenix MDS, Inc. (2) · Columbia University (1) · UCB BIOSCIENCES, Inc. (1)
United States (3) · Spain (2) · Israel (1) · Russia (1) · Turkey (Türkiye) (1)
PMID 23932787, PMID 24968719, PMID 28318037, PMID 29602790, PMID 33246973
2018 (1), 2023 (1)