15 completed, 6 terminated, 1 active not recruiting, 1 withdrawn. 13 Phase 2, 9 Phase 1, 3 Early Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 8, Terminated 4, Withdrawn 1 |
| Phase 1 | 9 | Completed 6, Terminated 3 |
| Early Phase 1 | 3 | Completed 2, Terminated 1 |
| Not applicable | 2 | Completed 2 |
Follow Stage I Adult Diffuse Large Cell Lymphoma: new trials by email Literature Review of Stage I Adult Diffuse Large Cell Lymphoma trials Research Report on Stage I Adult Diffuse Large Cell Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Carfilzomib, Rituximab, and Combination Chemotherapy in Treating Patients With Diffuse Large B-Cell Lymphoma Carfilzomib, Rituximab, Cyclophosphamide - Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma | Phase 1 / Phase 2 | Completed | Case Comprehensive Cancer Center | 48 | 2015-01-28 | 2024-05-29 |
| Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas lenalidomide, etoposide, prednisone - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | University of Chicago | 55 | 2014-07-29 | 2026-03-11 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas brentuximab vedotin, rituximab, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Northwestern University | 20 | 2013-03-05 | 2021-09-01 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Bortezomib and Filgrastim to Promote Stem Cell Mobilization in Patients With Non-Hodgkin Lymphoma or Multiple Myeloma bortezomib, filgrastim, autologous hematopoietic stem cell transplantation - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Not applicable | Completed | Barbara Ann Karmanos Cancer Institute | 23 | 2011-07-01 | 2021-05-10 |
| Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant infection prophylaxis and management, laboratory biomarker analysis, flow cytometry - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Active not recruiting | City of Hope Medical Center | 153 | 2011-01-11 | 2026-10-22 | |
| Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay - Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Wake Forest University Health Sciences | 16 | 2011-01-01 | 2018-09-07 |
| Lenalidomide And Rituximab as Maintenance Therapy in Treating Patients With B-Cell Non-Hodgkin Lymphoma lenalidomide, rituximab, polymerase chain reaction - Adult Non-Hodgkin Lymphoma, Adult Grade III Lymphomatoid Granulomatosis | Phase 1 | Terminated | Case Comprehensive Cancer Center | 5 | 2010-01-01 | 2015-11-26 |
| Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer rituximab, mycophenolate mofetil, tacrolimus - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Terminated | University of Nebraska | 20 | 2009-12-10 | 2023-09-06 |
| Gossypol, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery R-(-)-gossypol acetic acid, paclitaxel, carboplatin - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 36 | 2009-07-01 | 2013-01-10 |
| Oblimersen Sodium & Combination Chemotherapy in Treating Patients With Newly Diagnosed Diffuse Large B-Cell Lymphoma oblimersen sodium, rituximab, cyclophosphamide - Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma | Early Phase 1 | Terminated | University of Nebraska | 37 | 2008-07-23 | 2023-10-24 |
| Beclomethasone Dipropionate in Preventing Acute Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer beclomethasone dipropionate, placebo, tacrolimus - Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 140 | 2007-04-01 | 2021-02-03 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Fenretinide and Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma fenretinide, rituximab - Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma, B-cell Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 32 | 2005-10-01 | 2014-10-06 |
| Rituximab, Combination Chemotherapy, and 90-Yttrium Ibritumomab Tiuxetan for Patients With Stage I or II Non-Hodgkin's Lymphoma rituximab, prednisone, cyclophosphamide - Contiguous Stage II Adult Diffuse Large Cell Lymphoma, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 2 | Terminated | National Cancer Institute (NCI) | 62 | 2004-12-01 | 2017-05-25 |
| Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer Fludarabine Phosphate, Total-Body Irradiation, Peripheral Blood Stem Cell Transplantation - Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Previously Treated Myelodysplastic Syndrome | Phase 2 | Completed | Fred Hutchinson Cancer Center | 210 | 2004-11-01 | 2019-10-30 |
| Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer fludarabine phosphate, total-body irradiation, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Center | 150 | 2004-04-01 | 2020-01-29 |
| Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2003-09-01 | 2020-01-18 |
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Lymphoma, Large B-Cell, Diffuse (23) · Lymphoma, B-Cell, Marginal Zone (20) · Leukemia, Lymphocytic, Chronic, B-Cell (19) · Lymphoma, Follicular (19) · Lymphoma, Mantle-Cell (19) · Waldenstrom Macroglobulinemia (18) · Burkitt Lymphoma (17) · Lymphoma, Non-Hodgkin (17) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (17) · Lymphoma, Large-Cell, Immunoblastic (16) · Hodgkin Disease (13) · Lymphoma, Extranodal NK-T-Cell (11) · Leukemia, Myeloid, Accelerated Phase (10) · Lymphoma, Large-Cell, Anaplastic (10) · Lymphoma, T-Cell, Cutaneous (10)
Hemic and Lymphatic Diseases (23) · Immune System Diseases (23) · Immunoproliferative Disorders (23) · Lymphatic Diseases (23) · Lymphoma, B-Cell (23) · Lymphoproliferative Disorders (23) · Neoplasms (23) · Neoplasms by Histologic Type (23) · Lymphoma (22) · Blood Protein Disorders (20) · Cardiovascular Diseases (20) · Hematologic Diseases (20) · Hemorrhagic Disorders (20) · Hemostatic Disorders (20) · Neoplasms, Plasma Cell (20)
Rituximab (10) · Cyclophosphamide (9) · Mycophenolic Acid (6) · Peripheral Blood Stem Cell Transplantation (6) · fludarabine phosphate (6) · Doxorubicin (5) · Prednisone (5) · Tacrolimus (5) · Vincristine (5) · Whole-Body Irradiation (5) · Cyclosporine (4) · Granulocyte Colony-Stimulating Factor (3) · Biopsy (2) · Busulfan (2) · Etoposide (2)
Fred Hutchinson Cancer Center (6) · National Cancer Institute (NCI) (5) · Case Comprehensive Cancer Center (3) · City of Hope Medical Center (2) · University of Nebraska (2) · Barbara Ann Karmanos Cancer Institute (1) · Fox Chase Cancer Center (1) · Northwestern University (1) · University of Chicago (1) · Wake Forest University Health Sciences (1)
United States (23) · Germany (2) · Italy (2) · Denmark (1)
Brenda Sandmaier (2) · Ryotaro Nakamura (2) · Adam Petrich, MD (1) · Ajay Gopal (1) · Ann Woolfrey (1) · Brian Hill, MD (1) · Brian Hill, MD, PhD (1) · Colleen Delaney (1) · David Maloney (1) · Divaya Bhutani, M.D. (1) · Julie M Vose, MD MBA (1) · Lode Swinnen (1) · Mark Stein (1) · Mary Ann Knovich, MD (1) · Michael Millenson, MD, FACP (1)
PMID 32499241, PMID 18698002, PMID 25085357, PMID 26853648, PMID 30562587, PMID 31388792, PMID 40720747
P30CA015704 (4), P01CA018029 (3), P30CA036727 (2), P01CA078902 (1), P30CA014599 (1), P30CA022453 (1), P30CA043703 (1), P30CA046592 (1), R21CA119519 (1), R24HL074445 (1), R43HL106868 (1), RC2HL101844 (1), U01CA132194 (1), U10CA021115 (1)