69 completed, 21 terminated, 4 withdrawn, 3 active not recruiting. 53 Phase 1, 42 Phase 2, 11 Not applicable, 2 Early Phase 1, 1 Phase 3.
Follow Recurrent Adult Lymphoblastic Lymphoma: new trials by email Literature Review of Recurrent Adult Lymphoblastic Lymphoma trials Research Report on Recurrent Adult Lymphoblastic Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tagraxofusp and Low-Intensity Chemotherapy for the Treatment of CD123 Positive Relapsed or Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Cyclophosphamide, Cytarabine, Dexamethasone - Recurrent Adult Lymphoblastic Lymphoma, Recurrent B Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 4 | 2022-02-17 | 2025-08-11 |
| Venetoclax and Vincristine in Treating Patients With Relapsed or Refractory T-cell or B-cell Acute Lymphoblastic Leukemia Biospecimen Collection, Computed Tomography, Lumbar Puncture - Recurrent Adult Lymphoblastic Lymphoma, Recurrent B Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 40 | 2018-08-13 | 2026-10-06 |
| Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia Bortezomib, Clofarabine, Cyclophosphamide - Recurrent Acute Lymphoblastic Leukemia, Recurrent Adult Lymphoblastic Lymphoma | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 42 | 2017-08-09 | 2026-08-10 |
| Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma rituximab, lenalidomide, romidepsin - B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 1 / Phase 2 | Withdrawn | Mayo Clinic | 2016-10-01 | 2016-08-11 | |
| Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma carmustine, cytarabine, melphalan - Adult Nasal Type Extranodal NK/T-cell Lymphoma, AIDS-related Diffuse Large Cell Lymphoma | Not applicable | Withdrawn | Fred Hutchinson Cancer Center | 2015-02-01 | 2015-05-07 | |
| CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma 6,8-bis(benzylthio)octanoic acid, bendamustine hydrochloride, rituximab - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Terminated | Wake Forest University Health Sciences | 1 | 2014-12-01 | 2018-07-02 |
| Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Ibrutinib, Laboratory Biomarker Analysis, Pharmacological Study - Adult B Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 72 | 2014-09-01 | 2015-08-20 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells, autologous hematopoietic stem cell transplantation, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Cutaneous B-cell Non-Hodgkin Lymphoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 30 | 2013-10-08 | 2026-06-25 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas brentuximab vedotin, rituximab, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Northwestern University | 20 | 2013-03-05 | 2021-09-01 |
| Ipilimumab and Local Radiation for Selected Solid Tumors Ipilimumab, Radiation therapy - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Terminated | Stanford University | 3 | 2013-02-01 | 2024-01-24 |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Pilot Study Of Sirolimus Plus Multiagent Chemotherapy For Relapsed/Refractory Acute Lymphoblastic Leukemia/Lymphoma Sirolimus - Relapsed Lymphoblastic Leukemia, Recurrent Adult Lymphoblastic Lymphoma | Early Phase 1 | Terminated | Children's Hospital Medical Center, Cincinnati | 3 | 2012-08-01 | 2020-09-14 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant lenalidomide, rituximab, pharmacological study - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 3 | 2012-05-01 | 2017-07-27 |
| Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Alisertib, Laboratory Biomarker Analysis, Pharmacological Study - Adult B Acute Lymphoblastic Leukemia, Adult T Acute Lymphoblastic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 34 | 2012-04-16 | 2018-04-11 |
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Precursor Cell Lymphoblastic Leukemia-Lymphoma (98) · Burkitt Lymphoma (94) · Lymphoma, Follicular (92) · Lymphoma, Mantle-Cell (91) · Leukemia, Lymphocytic, Chronic, B-Cell (90) · Lymphoma, B-Cell, Marginal Zone (90) · Lymphoma, Large B-Cell, Diffuse (90) · Lymphoma, Non-Hodgkin (89) · Lymphoma, Large-Cell, Immunoblastic (88) · Waldenstrom Macroglobulinemia (74) · Hodgkin Disease (65) · Lymphoma, T-Cell, Cutaneous (63) · Mycosis Fungoides (63) · Sezary Syndrome (63) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (58)
Hematologic Diseases (98) · Hemic and Lymphatic Diseases (98) · Immune System Diseases (98) · Immunoproliferative Disorders (98) · Leukemia (98) · Leukemia, Lymphoid (98) · Lymphatic Diseases (98) · Lymphoproliferative Disorders (98) · Neoplasms by Histologic Type (98) · Lymphoma (96) · Neoplasms (96) · Lymphoma, B-Cell (95) · DNA Virus Infections (94) · Herpesviridae Infections (94) · Infections (94)
Peripheral Blood Stem Cell Transplantation (20) · fludarabine phosphate (18) · Whole-Body Irradiation (17) · Mycophenolic Acid (16) · Rituximab (16) · Cyclophosphamide (13) · Cyclosporine (13) · Etoposide (8) · Tacrolimus (8) · Flow Cytometry (7) · Bortezomib (6) · Busulfan (6) · Filgrastim (6) · Granulocyte Colony-Stimulating Factor (6) · Methotrexate (6)
National Cancer Institute (NCI) (37) · Fred Hutchinson Cancer Center (24) · Case Comprehensive Cancer Center (6) · City of Hope Medical Center (5) · Roswell Park Cancer Institute (4) · Mayo Clinic (3) · M.D. Anderson Cancer Center (2) · University of Washington (2) · Wake Forest University Health Sciences (2) · Amir Mortazavi (1) · Barbara Ann Karmanos Cancer Institute (1) · Children's Hospital Medical Center, Cincinnati (1) · ECOG-ACRIN Cancer Research Group (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Martin, Paul (1)
United States (95) · Italy (8) · Germany (5) · Canada (3) · Puerto Rico (2) · Australia (1) · Denmark (1)
Ajay Gopal (7) · Brenda Sandmaier (5) · David Maloney (5) · Paul Martin (3) · George Chen (2) · Patricia LoRusso (2) · Philip McCarthy (2) · Ramesh Ramanathan (2) · Ryotaro Nakamura (2) · Adam Petrich, MD (1) · Amir Mortazavi, MD (1) · Anas Younes (1) · Ann Woolfrey (1) · Antonius Miller (1) · Barbara Pro (1)
PMID 32499241, PMID 18974373, PMID 19900571, PMID 20837940, PMID 21508413, PMID 22259028, PMID 24474568, PMID 24530971, PMID 25085357, PMID 26213141, PMID 26764356, PMID 26853648, PMID 26943915, PMID 27118452, PMID 28270022, PMID 28314788, PMID 28419486, PMID 28817727, PMID 29292843, PMID 29572391, PMID 30454872, PMID 30562587, PMID 30957229, PMID 31388792, PMID 31481800, PMID 31617432, PMID 32628342, PMID 33420905, PMID 33492438, PMID 34515338, PMID 36282798, PMID 39415930
P30CA015704 (14), P01CA018029 (5), U01CA062487 (5), U01CA062491 (5), P30CA015083 (4), U01CA062505 (4), U01CA099168 (4), N01CM62202 (3), P01CA044991 (3), P01CA078902 (3), U01CA062502 (3), U01CA076576 (3), P30CA016058 (2), P30CA016672 (2), P30CA022453 (2)