91 completed, 27 terminated, 6 unknown, 4 withdrawn. 70 Phase 1, 63 Phase 2, 12 Not applicable, 3 Early Phase 1, 2 Phase 3.
Follow Recurrent Adult Diffuse Large Cell Lymphoma: new trials by email Literature Review of Recurrent Adult Diffuse Large Cell Lymphoma trials Research Report on Recurrent Adult Diffuse Large Cell Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 anti-CD19/22-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | Chinese PLA General Hospital | 30 | 2017-08-01 | 2019-04-17 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 anti-CD19/20-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Chinese PLA General Hospital | 100 | 2017-04-01 | 2020-09-02 |
| Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma rituximab, lenalidomide, romidepsin - B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 1 / Phase 2 | Withdrawn | Mayo Clinic | 2016-10-01 | 2016-08-11 | |
| Anti-CD22 CAR-T Therapy for CD19-refractory or Resistant Lymphoma Patients Retroviral vector-transduced autologous T cells to express CD22-specific CARs - Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Follicular Lymphoma | Phase 1 | Unknown | Xinqiao Hospital of Chongqing | 20 | 2016-03-01 | 2017-03-10 |
| Competitive Transfer of αCD19-TCRz-CD28 and αCD19-TCRz-CD137 CAR-T Cells for B-cell Leukemia/Lymphoma anti-CD19 CAR-T, Fludarabine, Cyclophosphamide - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine | 20 | 2016-02-01 | 2017-03-16 |
| Memory-enriched CAR-T Cells Immunotherapy for B Cell Lymphoma CD19.CAR-T cells - Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Follicular Lymphoma | Phase 1 / Phase 2 | Unknown | Xinqiao Hospital of Chongqing | 20 | 2015-12-01 | 2019-02-27 |
| Selinexor and Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Aggressive Non-Hodgkin Lymphoma Selinexor, Ibrutinib, Pharmacological Study - Prolymphocytic Leukemia, Recurrent Adult Diffuse Large Cell Lymphoma | Phase 1 | Completed | Jennifer Woyach | 34 | 2015-06-09 | 2025-06-10 |
| Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma carmustine, cytarabine, melphalan - Adult Nasal Type Extranodal NK/T-cell Lymphoma, AIDS-related Diffuse Large Cell Lymphoma | Not applicable | Withdrawn | Fred Hutchinson Cancer Center | 2015-02-01 | 2015-05-07 | |
| CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma 6,8-bis(benzylthio)octanoic acid, bendamustine hydrochloride, rituximab - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Terminated | Wake Forest University Health Sciences | 1 | 2014-12-01 | 2018-07-02 |
| Everolimus and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory Hematologic Cancer everolimus, bendamustine hydrochloride - Recurrent Adult Diffuse Large Cell Lymphoma, Recurrent Adult Hodgkin Lymphoma | Phase 1 | Completed | University of California, Davis | 20 | 2014-10-01 | 2019-01-04 |
| Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Ibrutinib, Laboratory Biomarker Analysis, Pharmacological Study - Adult B Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 72 | 2014-09-01 | 2015-08-20 |
| Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma BTK inhibitor PCI-32765, rituximab, bendamustine hydrochloride - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 1 | Active not recruiting | Kami Maddocks, MD | 48 | 2014-03-26 | 2026-07-22 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells, autologous hematopoietic stem cell transplantation, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Cutaneous B-cell Non-Hodgkin Lymphoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 30 | 2013-10-08 | 2026-06-25 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Alisertib With and Without Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma alisertib, rituximab, laboratory biomarker analysis - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 2 | Terminated | Ohio State University Comprehensive Cancer Center | 14 | 2013-05-21 | 2018-06-06 |
| Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma or Newly Diagnosed or Relapsed or Refractory Intraocular Lymphoma Dexamethasone, Laboratory Biomarker Analysis, Pharmacological Study - B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma, Central Nervous System Lymphoma | Phase 1 | Completed | Mayo Clinic | 29 | 2013-04-08 | 2019-07-22 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
Showing 20 of 131. Sign in to see all of them.
Lymphoma, Large B-Cell, Diffuse (131) · Lymphoma, Mantle-Cell (120) · Lymphoma, Follicular (115) · Leukemia, Lymphocytic, Chronic, B-Cell (104) · Burkitt Lymphoma (99) · Lymphoma, B-Cell, Marginal Zone (99) · Lymphoma, Non-Hodgkin (95) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (91) · Lymphoma, Large-Cell, Immunoblastic (89) · Waldenstrom Macroglobulinemia (82) · Hodgkin Disease (69) · Lymphoma, T-Cell, Cutaneous (65) · Mycosis Fungoides (65) · Sezary Syndrome (65) · Lymphoma, Large-Cell, Anaplastic (63)
Hemic and Lymphatic Diseases (131) · Immune System Diseases (131) · Immunoproliferative Disorders (131) · Lymphatic Diseases (131) · Lymphoma (131) · Lymphoproliferative Disorders (131) · Neoplasms by Histologic Type (131) · Neoplasms (129) · Lymphoma, B-Cell (128) · Hematologic Diseases (113) · Leukemia (109) · Leukemia, Lymphoid (109) · Disease Attributes (105) · Pathologic Processes (105) · Pathological Conditions, Signs and Symptoms (105)
Rituximab (22) · Peripheral Blood Stem Cell Transplantation (21) · fludarabine phosphate (18) · Whole-Body Irradiation (17) · Mycophenolic Acid (16) · Cyclophosphamide (13) · Cyclosporine (13) · Etoposide (10) · Bortezomib (8) · Tacrolimus (8) · Filgrastim (7) · Flow Cytometry (7) · Granulocyte Colony-Stimulating Factor (7) · Bendamustine Hydrochloride (6) · Busulfan (6)
National Cancer Institute (NCI) (55) · Fred Hutchinson Cancer Center (25) · Mayo Clinic (7) · Case Comprehensive Cancer Center (6) · City of Hope Medical Center (5) · Chinese PLA General Hospital (4) · Roswell Park Cancer Institute (4) · University of Washington (3) · Wake Forest University Health Sciences (2) · Xinqiao Hospital of Chongqing (2) · Amir Mortazavi (1) · Barbara Ann Karmanos Cancer Institute (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Jennifer Woyach (1) · Kami Maddocks, MD (1)
United States (120) · China (7) · Italy (7) · Germany (4) · Canada (3) · Denmark (1)
Ajay Gopal (9) · David Maloney (5) · Brenda Sandmaier (4) · Paul Martin (3) · Sonali Smith (3) · Anas Younes (2) · Brenda Cooper (2) · George Chen (2) · Kristie Blum (2) · Patricia LoRusso (2) · Philip McCarthy (2) · Ramesh Ramanathan (2) · Ryotaro Nakamura (2) · Thomas Witzig (2) · Alison Stopeck (1)
PMID 32499241, PMID 34515338, PMID 18256325, PMID 18974373, PMID 19900571, PMID 20837940, PMID 21508413, PMID 22259028, PMID 23256542, PMID 24241210, PMID 24474568, PMID 24530971, PMID 25085357, PMID 25317870, PMID 25355819, PMID 25444722, PMID 26213141, PMID 26451310, PMID 26764356, PMID 26853648, PMID 26943915, PMID 27118452, PMID 28270022, PMID 28314788, PMID 28817727, PMID 28869931, PMID 29263894, PMID 29292843, PMID 29572391, PMID 29599530, PMID 30262659, PMID 30454872, PMID 30562587, PMID 30596402, PMID 31076448, PMID 31388792, PMID 31481800, PMID 31815579, PMID 32245502, PMID 32628342, PMID 33420905, PMID 33492438, PMID 36282798, PMID 41804087
P30CA015704 (16), P30CA015083 (7), N01CM62202 (5), U01CA062487 (5), U01CA062491 (5), U01CA062502 (5), U01CA076576 (5), U01CA099168 (5), N01CM62201 (4), P01CA018029 (4), P01CA044991 (4), U01CA062505 (4), U10CA032102 (4), N01CM17003 (3), P01CA078902 (3)