10 completed, 2 terminated, 2 unknown, 1 not yet recruiting. 15 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 15 | Completed 10, Terminated 2, Unknown 2, Not yet recruiting 1 |
Follow Primary Open Angle Glaucoma: new trials by email Literature Review of Primary Open Angle Glaucoma trials Research Report on Primary Open Angle Glaucoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rocklatan Adds Pressure Reduction After MIGS (Minimally Invasive Glaucoma Surgery) Rocklatan (netarsudil 0.02% and latanoprost 0.005%), Systane - Primary Open Angle Glaucoma | Phase 4 | Not yet recruiting | Center for Sight Las Vegas | 68 | 2025-07-15 | 2025-07-03 |
| A Clinical Trial Comparing the OMNI Surgical System to Standard Medical Treatment in Patients With Primary Open Angle Glaucoma OMNI Surgical System, Latanoprost plus adjunctive glaucoma medication - Primary Open Angle Glaucoma | Phase 4 | Terminated | Sight Sciences, Inc. | 2 | 2024-08-21 | 2025-01-29 |
| Tafluprost Preservative Free Switch Study preservative free tafluprost 0.0015% - Glaucoma, Primary Open Angle Glaucoma | Phase 4 | Completed | Tun Hussein Onn National Eye Hospital | 28 | 2019-02-01 | 2020-12-04 |
| Efficacy and Safety of Latanoprost/Timolol for Primary Open Angle Glaucoma Latanoprost/Timolol - Primary Open Angle Glaucoma | Phase 4 | Unknown | Universiti Kebangsaan Malaysia Medical Centre | 40 | 2019-01-02 | 2019-09-23 |
| A Comparison of Xalatan (Latanoprost) to Apo-latanoprost and Co-latanoprost in the Treatment of Glaucoma Xalatan, Apo-Latanoprost, Co-Latanoprost - POAG, Primary Open Angle Glaucoma | Phase 4 | Unknown | Dr. David Yan | 60 | 2015-09-01 | 2017-07-26 |
| Efficacy of the Brand-name Latanoprost and One of Its Generic Version in Primary Open Angle Glaucoma and Ocular Hypertension Generic latanoprost, Brand-name latanoprost - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Terminated | CHU de Quebec-Universite Laval | 60 | 2014-01-01 | 2017-07-25 |
| Evaluation of the XEN Implant in Moderate Primary Open Angle Glaucoma (POAG) Participants XEN® Gel Stent, Cataract Surgery - Primary Open Angle Glaucoma | Phase 4 | Completed | AqueSys, Inc. | 199 | 2013-12-05 | 2019-04-22 |
| Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose Monoprost, Lumigan 0.01%, Lumigan 0.03% Unit Dose - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Laboratoires Thea | 379 | 2013-12-01 | 2020-04-02 |
| An Open, Non-randomized Pilot Study on the Effect of Preservative Free Tafluprost (Saflutan® Augentropfen) in Patients With Ocular Hypertension or Primary Open Angle Glaucoma With an Uncontrolled Intraocular Pressure of 30 mmHg and More Saflutan® 15 microgram/ml Augentropfen im Einzeldosisbehältnis - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Dr. Anton Hommer | 16 | 2013-10-01 | 2015-04-23 |
| Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension Primary Selective Laser Trabeculoplasty Treatment Pathway, Primary Medical Treatment Pathway - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Moorfields Eye Hospital NHS Foundation Trust | 718 | 2012-10-01 | 2018-01-10 |
| Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP) Goldmann and Perkins applanation tonometry, TAFLUPROST 0.0015% EYEDROPS, LATANOPROST 0.005% EYEDROPS - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | 40 | 2011-03-01 | 2013-05-07 |
| Efficacy And Safety of Pneumatic Trabeculoplasty "model 1000 PNT vacuum controller" (the vacuum device for ocular suction) - Primary Open Angle Glaucoma | Phase 4 | Completed | University of Catanzaro | 27 | 2009-06-01 | 2012-02-28 |
| Study of the Intraocular Pressure (IOP)-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% in Patients With Glaucoma or Ocular Hypertension brinzolamide 1.0% - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 30 | 2006-09-01 | 2016-11-18 |
| 24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients timolol maleate 0.5%, latanoprost/timolol fixed combination, placebo (artificial tears) - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Aristotle University Of Thessaloniki | 30 | 2006-04-01 | 2014-05-12 |
| Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin Analogs Brimonidine purite 0.15%, Dorzolamide 2%, Brinzolamide 1% - Primary Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Northwestern Ophthalmic Institute S.C. | 120 | 2006-01-01 | 2008-05-08 |
Glaucoma, Open-Angle (15) · Ocular Hypertension (10) · Glaucoma (3)
Eye Diseases (15) · Glaucoma (12) · Ocular Hypertension (5)
Latanoprost (6) · tafluprost (2) · Bimatoprost (1) · Cataract Extraction (1) · Lubricant Eye Drops (1) · Ophthalmic Solutions (1) · Timolol (1) · brinzolamide (1) · dorzolamide (1) · netarsudil (1)
Alcon Research (1) · AqueSys, Inc. (1) · Aristotle University Of Thessaloniki (1) · Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (1) · CHU de Quebec-Universite Laval (1) · Center for Sight Las Vegas (1) · Dr. Anton Hommer (1) · Dr. David Yan (1) · Laboratoires Thea (1) · Moorfields Eye Hospital NHS Foundation Trust (1) · Northwestern Ophthalmic Institute S.C. (1) · Sight Sciences, Inc. (1) · Tun Hussein Onn National Eye Hospital (1) · Universiti Kebangsaan Malaysia Medical Centre (1) · University of Catanzaro (1)
United States (4) · Italy (3) · Austria (2) · Canada (2) · Greece (2) · Malaysia (2) · United Kingdom (2) · Belgium (1) · France (1) · Germany (1) · Poland (1) · Spain (1) · Switzerland (1) · Venezuela (1)
Christophe Baudouin, Professor (1) · David B Yan, M.D., F.R.C.S. (C) (1) · Gus Gazzard, MA FRCOphth (1) · Hsien Han Lim (1) · John Liu, PhD (1) · Luciano Quaranta, MD (1) · Luigi Varano, M. D. (1) · Thomas E. Bournias, MD (1) · Vanessa Vera, MD (1)
PMID 19157559, PMID 20553122, PMID 23681371, PMID 29267575, PMID 30758653