8 completed, 7 unknown, 2 active not recruiting, 1 withdrawn. 18 Phase 1, 13 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 8, Unknown 7, Active not recruiting 2, Withdrawn 1 |
| Phase 2 | 13 | Unknown 6, Completed 5, Active not recruiting 1, Withdrawn 1 |
Follow Premature Ovarian Failure: new trials by email Literature Review of Premature Ovarian Failure trials Research Report on Premature Ovarian Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous ADMSC Transplantation in Patients With POI stem cell therapy - Premature Ovarian Failure | Phase 1 | Unknown | Mongolian National University of Medical Sciences | 10 | 2024-01-15 | 2023-11-15 |
| Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure Intra-ovarian injection of bone marrow mesenchymal stromal cells-derived extracellular vesicles - Premature Ovarian Failure | Phase 1 / Phase 2 | Completed | Royan Institute | 10 | 2023-02-20 | 2026-07-15 |
| Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment. Ovarian graft - Locally Advanced Cervical Carcinoma, Premature Ovarian Failure | Phase 1 / Phase 2 | Active not recruiting | MARILIA ALBANEZI BERTOLAZZI | 22 | 2022-06-08 | 2025-09-05 |
| The Use of Expandeded Mesenchymal Stromal Cells (MSC) in Premature Ovarian Failure (POF) in Adult Humans expanded autologous bone marrow derived MSC Intravaginally, expanded autologous bone marrow derived MSC Laporoscopic, EV - Premature Ovarian Failure | Phase 1 | Active not recruiting | University of Jordan | 10 | 2022-01-01 | 2025-01-28 |
| Ovarian Injection of PRP (Platelet -Rich Plasma) Vs Normal Saline in Premature Ovarian Insufficiency platelet rich plasma, Normal saline - Premature Ovarian Failure | Phase 1 / Phase 2 | Unknown | Ahmed Saad | 60 | 2021-06-20 | 2021-06-10 |
| A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure human amniotic epithelial cells (hAECs) transplantation - Primary Ovarian Insufficiency, Premature Ovarian Failure | Phase 1 | Completed | International Peace Maternity and Child Health Hospital | 36 | 2020-06-20 | 2023-03-01 |
| Very Small Embryonic-like Stem Cells for Ovary very small embryonic-like stem cell - Stem Cell Transplant Complications, Premature Ovarian Failure | Phase 1 / Phase 2 | Withdrawn | Fuda Cancer Hospital, Guangzhou | 2019-07-03 | 2020-10-19 | |
| Stem Cell Therapy and Growth Factor Ovarian in Vitro Activation SEGOVA procedure - Menopause, Menopause Ovarian Failure | Phase 1 / Phase 2 | Unknown | Forever Young d.o.o. | 100 | 2019-06-01 | 2020-08-06 |
| Effects of UCA-PSCs in Women With POF transplantation of human UCA-PSCs or WJ-MSCs into ovaries of POF patients - Premature Ovarian Failure | Phase 1 | Completed | Li-jun Ding | 20 | 2018-12-01 | 2021-12-01 |
| Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility Human Chorionic Gonadotropin (hCG), Gonadotropins, GNRH-A Triptorelin - Female Infertility, Female Infertility Due to Ovulatory Disorder | Phase 1 / Phase 2 | Completed | Lebanese University | 200 | 2018-02-01 | 2023-05-09 |
| Inovium Ovarian Rejuvenation Trials Autologous PRP injection into human ovarian tissue - Perimenopausal Disorder, Menopause | Phase 1 | Completed | Ascendance Biomedical | 200 | 2017-06-01 | 2020-04-20 |
| Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF HUC-MSCs Transplantation, HUC-MSCs with Injectable Collagen Scaffold Transplantation - Premature Ovarian Failure | Phase 1 / Phase 2 | Completed | Chinese Academy of Sciences | 23 | 2015-10-01 | 2020-01-13 |
| Autologous Adipose Derived Mesenchymal Stromal Cells Transplantation in Women With Premature Ovarian Failure (POF) Intraovarian injection of Adipose derived Stromal cells (ADSCs) - Premature Ovarian Failure | Phase 1 / Phase 2 | Unknown | Royan Institute | 9 | 2015-06-01 | 2017-04-27 |
| Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients With Premature Ovarian Failure (POF) Stem Cells - Premature Ovarian Failure | Phase 1 / Phase 2 | Unknown | Stem Cells Arabia | 50 | 2015-01-01 | 2018-05-17 |
| Autologous Stem Cells Transplantation in Patients With Idiopathic and Drug Induced Premature Ovarian Failure Biological: Stem Cells - Premature Ovarian Failure | Phase 1 / Phase 2 | Unknown | El-Rayadh Fertility Centre | 60 | 2014-01-01 | 2014-01-23 |
| Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure Stem Cell - Premature Ovarian Failure | Phase 1 / Phase 2 | Completed | Al-Azhar University | 10 | 2012-03-01 | 2014-06-02 |
| "It is a Real" The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian Failure Stem cell - Premature Ovarian Failure | Phase 1 / Phase 2 | Completed | Al-Azhar University | 112 | 2012-03-01 | 2015-02-26 |
| Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure Stem Cell Preparation and Injection - Premature Ovarian Failure | Phase 1 / Phase 2 | Unknown | Sayed Bakry | 60 | 2012-03-01 | 2014-05-13 |
Primary Ovarian Insufficiency (18) · Infertility (3) · Infertility, Female (2) · Menopause, Premature (2) · Ovarian Dysgenesis 2 (2) · Premature Ovarian Failure 2a (2) · Premature Ovarian Failure 3 (2) · Premature Ovarian Failure 5 (2) · Premature Ovarian Failure 6 (2) · Premature Ovarian Failure 7 (2) · Endometriosis (1) · Endometritis (1) · Leiomyoma (1) · Polycystic Ovary Syndrome (1) · Pregnancy, Ectopic (1)
Adnexal Diseases (18) · Endocrine System Diseases (18) · Female Urogenital Diseases (18) · Female Urogenital Diseases and Pregnancy Complications (18) · Genital Diseases (18) · Genital Diseases, Female (18) · Gonadal Disorders (18) · Ovarian Diseases (18) · Urogenital Diseases (18) · Cysts (1) · Fallopian Tube Diseases (1) · Neoplasms (1) · Neoplasms by Histologic Type (1) · Neoplasms, Connective and Soft Tissue (1) · Neoplasms, Muscle Tissue (1)
Stem Cell Transplantation (2) · Chorionic Gonadotropin (1) · Gonadotropins (1) · Injections (1) · LHRH, Ac-Nal(1)-Cpa(2)-Trp(3)-Arg(6)-Ala(10)- (1) · Menotropins (1) · Saline Solution (1) · Sodium Chloride (1) · Transplantation (1) · Triptorelin Pamoate (1) · cetrorelix (1)
Al-Azhar University (2) · Royan Institute (2) · Ahmed Saad (1) · Ascendance Biomedical (1) · Chinese Academy of Sciences (1) · El-Rayadh Fertility Centre (1) · Forever Young d.o.o. (1) · Fuda Cancer Hospital, Guangzhou (1) · International Peace Maternity and Child Health Hospital (1) · Lebanese University (1) · Li-jun Ding (1) · MARILIA ALBANEZI BERTOLAZZI (1) · Mongolian National University of Medical Sciences (1) · Sayed Bakry (1) · Stem Cells Arabia (1)
Egypt (5) · China (4) · Iran (2) · Jordan (2) · Brazil (1) · Lebanon (1) · Malta (1) · Mongolia (1) · North Macedonia (1) · Serbia (1) · United States (1)
Hala Gabr, MD (2) · Hala N Hosni, Professor (2) · Mahmoud Edessy, Professor (2) · Medhat Kamel, Msc (2) · Sayed Bakry, PhD (2) · Aleksandar Ljubic, MD, PhD (1) · Batsuren Choijamts, Ph.D (1) · Dongmei Lai, M.D. (1) · Dr Abdalla Awidi, MD (1) · E Scott Sills, MD PhD (1) · Faezeh Shekari, Ph.D (1) · Hala Hosni, MD (1) · Hamid Gourabi, PhD (1) · Hamza El Tahan, BSc (1)
PMID 33407794, PMID 10582785, PMID 21994953, PMID 22271773, PMID 24406076, PMID 26303743, PMID 26664408, PMID 26872610, PMID 27008889, PMID 29117576, PMID 29486615, PMID 30123994, PMID 30796792, PMID 30829083, PMID 32195207, PMID 34155864, PMID 39165278, PMID 8576878