8 recruiting, 5 completed, 2 terminated, 2 unknown. 5 Not applicable, 4 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Recruiting 3, Completed 2 |
| Phase 2 | 4 | Recruiting 2, Completed 1, Terminated 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Perihilar Cholangiocarcinoma: new trials by email Literature Review of Perihilar Cholangiocarcinoma trials Research Report on Perihilar Cholangiocarcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prognostic Evaluation and Systematic Re-Assessment of Cholangiocarcinoma Therapy Intrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma | Not yet recruiting | Karolinska University Hospital | 900 | 2026-09-01 | 2026-09-11 | |
| Neoadjuvant Gemcitabine and Cisplatin in Combination With Perioperative Pembrolizumab Versus Upfront Surgery for Patients With Primary Resectable and Borderline Resectable Perihilar and Distal Cholangiocarcinoma Pembrolizumab, Gemcitabine, Cisplatin - Extrahepatic Cholangiocarcinoma, Perihilar Cholangiocarcinoma | Phase 2 / Phase 3 | Recruiting | Amsterdam UMC, location VUmc | 150 | 2026-04-17 | 2026-08-25 |
| Preoperative Evaluation of Lymph Nodes of Cholangiocarcinoma (POELH-III) Registration of all findings during preoperative Endoscopic Ultrasound - Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma (Icc) | Recruiting | Erasmus Medical Center | 250 | 2026-02-05 | 2026-09-10 | |
| Liver Transplantation for Unresectable Perihilar Cholangiocarcinoma Perihilar Cholangiocarcinoma, Klatskin Tumor | Recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 8 | 2025-06-01 | 2025-05-23 | |
| Perioperative Treatment of High-risk Resectable CCA With HAIC Plus A+T: Neobrave CCA Gemcitabine Oxaliplatin and 5FU - Intrahepatic Cholangiocarcinoma (Icc), Perihilar Cholangiocarcinoma | Phase 2 | Terminated | Peking University | 1 | 2024-12-31 | 2026-01-28 |
| Robotically Assisted Surgery For Perihilar Cholangiocarcinoma: A Prospective Study Major hepatectomy - Cholangiocarcinoma Cancer, Perihilar Cholangiocarcinoma | Recruiting | Azienda Ospedaliera di Padova | 32 | 2024-06-07 | 2024-12-06 | |
| LIver TrAnspLantation for Non-resectable Peri-HIlar cholangioCArcinoma (LITALHICA) Liver transplantation - Perihilar Cholangiocarcinoma | Not applicable | Recruiting | Azienda Sanitaria Ospedaliera | 50 | 2024-01-15 | 2026-04-03 |
| Endoscopic Drainage of Presumed Resectable pCCA Using an Intrahepatic Plastic Stent With Retrieval String Intrahepatic biliary stent with retrieval string - Perihilar Cholangiocarcinoma | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 40 | 2023-03-01 | 2026-05-26 |
| PD-1 Antibody Plus GEMOX as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma PD-1antibody plus GEMOX - Perihilar Cholangiocarcinoma | Phase 2 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 62 | 2023-01-31 | 2026-02-09 |
| Endobiliary Radiofrequency Ablation for Malignant Biliary Obstruction Due to Perihilar Cholangiocarcinoma Endobiliary radiofrequency ablation (eRFA), uncovered self-expanding metal stent (uSEMS) - Perihilar Cholangiocarcinoma | Not applicable | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 122 | 2022-10-22 | 2026-05-26 |
| Endoscopy and Radiology-guided Ablation for Inoperable Cholangiocarcinoma Endoluminal radiofrequency ablation, Endoscopic biliary stenting - Perihilar Cholangiocarcinoma | Not applicable | Completed | Clinical Hospital Colentina | 26 | 2022-08-01 | 2026-07-29 |
| Biliary Drainage Plus HAIC in Locally Advanced pCCA oxaliplatin and 5-fluorouracil, Biliary Drainage, Best Supportive Care - Perihilar Cholangiocarcinoma | Phase 2 | Completed | Peking University | 127 | 2021-11-01 | 2025-12-18 |
| Liver Transplantation for Non-resectable Perihilar Cholangiocarcinoma Liver transplant - Perihilar Cholangiocarcinoma, Klatskin Tumor | Not applicable | Recruiting | Oslo University Hospital | 15 | 2021-09-01 | 2026-10-16 |
| Endoscopic Versus Radiologic Biliary Drainage for Perihilar Malignant Obstruction Endoscopic drainage, Percutaneous transhepatic biliary drainage - Perihilar Cholangiocarcinoma, Jaundice, Obstructive | Unknown | Central Hospital, Nancy, France | 100 | 2021-07-15 | 2021-10-15 | |
| Prognosis of Nutritional Status for Surgical Peri Hilar Cholangiocarcinoma Nutritional evaluation - Perihilar Cholangiocarcinoma | Unknown | Central Hospital, Nancy, France | 40 | 2021-04-01 | 2021-04-15 | |
| Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer Multi-Platform Profiling with Organoid Drug Sensitivity Screening and ctDNA Monitoring - Biliary Tract Cancer, Cholangiocarcinoma | Terminated | University of Washington | 14 | 2020-07-08 | 2025-07-10 | |
| Minimally Invasive Versus Open Surgery for PHC No intervention - Perihilar Cholangiocarcinoma | Completed | Renyi Qin | 783 | 2018-05-01 | 2022-06-02 | |
| Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma Perihilar Cholangiocarcinoma | Completed | Beijing Tsinghua Chang Gung Hospital | 62 | 2018-04-13 | 2024-04-11 |
Klatskin Tumor (18) · Cholangiocarcinoma (6) · Biliary Tract Neoplasms (2) · Cirrhosis, Familial, with Pulmonary Hypertension (2) · Bile Duct Neoplasms (1) · Common Bile Duct Neoplasms (1) · Congenital contractural arachnodactyly (1) · Gallbladder Neoplasms (1) · Jaundice, Obstructive (1) · Sarcopenia (1)
Adenocarcinoma (18) · Carcinoma (18) · Neoplasms (18) · Neoplasms by Histologic Type (18) · Neoplasms, Glandular and Epithelial (18) · Cholangiocarcinoma (12) · Biliary Tract Diseases (3) · Digestive System Diseases (3) · Digestive System Neoplasms (3) · Neoplasms by Site (3) · Bile Duct Diseases (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Atrophy (1) · Bile Duct Neoplasms (1)
Fluorouracil (2) · Liver Transplantation (2) · Cisplatin (1) · Gemcitabine (1) · Oxaliplatin (1) · gemcitabine-oxaliplatin regimen (1) · pembrolizumab (1)
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Central Hospital, Nancy, France (2) · Peking University (2) · Amsterdam UMC, location VUmc (1) · Azienda Ospedaliera di Padova (1) · Azienda Sanitaria Ospedaliera (1) · Beijing Tsinghua Chang Gung Hospital (1) · Clinical Hospital Colentina (1) · Erasmus Medical Center (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Karolinska University Hospital (1) · Oslo University Hospital (1) · Renyi Qin (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · University of Washington (1)
China (5) · Netherlands (4) · Italy (3) · France (2) · Norway (1) · Romania (1) · United States (1)
Ahmet Ayav, PhD (1) · Chao Liu, PhD (1) · Enrico Gringeri, Prof. (1) · Gentry King, MD (1) · Rogier P. Voermans (1) · Shuo Jin, PhD (1) · Xiaodong Wang (1) · Xiaodong Wang, M.D. (1)