10 recruiting, 2 active not recruiting, 2 completed. 9 Phase 2, 2 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Recruiting 7, Active not recruiting 2 |
| Not applicable | 2 | Completed 1, Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Paget Disease, Extramammary: new trials by email Literature Review of Paget Disease, Extramammary trials Research Report on Paget Disease, Extramammary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trastuzumab Rezetecan in Advanced Solid Tumors Refractory to Standard Therapies SHR-A1811, Trastuzumab Rezetecan - Urachal Cancer, Advanced Solid Tumor Cancer | Phase 2 | Recruiting | Sheng Zhang | 90 | 2025-12-18 | 2025-12-30 |
| A Study of Disitamab Vedotin + Bicalutamide in HER2/AR-Positive Scrotal Paget's Disease Disitamab Vedotin combined with Bicalutamide - Extramammary Paget Disease, Scrotum Disease | Phase 2 | Recruiting | Fudan University | 20 | 2025-08-01 | 2025-08-12 |
| A Study of Fluorescein Sodium in People Undergoing Vulvectomy for Extramammary Paget's Disease (EMPD) Fluorescein Sodium - Extramammary Paget's Disease | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 27 | 2025-03-07 | 2026-01-12 |
| A Study of RC48-ADC Combined With JS001 for Advanced Extramammary Paget Disease of the Scrotum Disitamab Vedotin combined with Toripalimab - Paget Disease, Extramammary, Scrotum Disease | Phase 2 | Recruiting | Fujian Medical University Union Hospital | 20 | 2025-01-01 | 2025-01-24 |
| Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors Albumin-paclitaxel Injection - Paget Disease, Extramammary, Rhabdomyosarcoma | Phase 2 | Recruiting | Fudan University | 100 | 2024-11-30 | 2024-12-20 |
| Ivonescimab in the Treatment of Multiple Advanced Tumors Ivocizumab - Pheochromocytoma/Paraganglioma, Rhabdomyosarcoma | Phase 2 | Recruiting | Fudan University | 400 | 2024-11-20 | 2025-08-24 |
| A Study on the Efficacy of Disitamab Vedotin in Advanced HER2-positive Paget's Disease. RC48 - Mammary or Extramammary Paget's Disease | Phase 2 | Recruiting | Fudan University | 36 | 2024-08-15 | 2024-12-17 |
| A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer MQ719, Pembrolizumab - Cutaneous Squamous Cell Carcinoma, SCC - Squamous Cell Carcinoma | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 56 | 2023-05-04 | 2026-08-12 |
| PAGETEX® Photodynamic Therapy Device for the Treatment of Extra Mammary Paget's Disease of the Vulva (EMPV). pagetex PDT - Paget Disease of the Vulva, Paget Disease, Extramammary | Not applicable | Recruiting | University Hospital, Lille | 24 | 2019-08-27 | 2026-05-05 |
| Gynecologic Extramammary Paget's Disease Extramammary Paget's Disease, Extramammary Paget Disease | Recruiting | Mayo Clinic | 100 | 2018-02-19 | 2026-01-28 | |
| Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Anaplastic Large Cell Lymphoma, ALK-Negative, Anaplastic Large Cell Lymphoma, ALK-Positive | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 68 | 2017-09-27 | 2026-08-13 |
| Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Biospecimen Collection, Computed Tomography, Echocardiography Test - Acinar Cell Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 798 | 2017-01-30 | 2026-06-17 |
| Topical 5% Imiquimod Cream for Vulvar Paget's Disease Imiquimod, paracetamol, lidocaine in Vaseline ointment - Paget Disease, Extramammary | Phase 3 | Completed | University Medical Center Nijmegen | 25 | 2015-05-01 | 2020-01-02 |
| Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer Videoscopic procedure, Open, traditional approach - Melanoma, Merkel Cell Carcinoma | Not applicable | Completed | Emory University | 29 | 2009-06-01 | 2015-05-06 |
Carcinoma, Basal Cell (4) · Carcinoma, Merkel Cell (3) · Penile Neoplasms (3) · Urachal cancer (3) · Carcinoma, Squamous Cell (2) · Carcinoma, Transitional Cell (2) · Hemangiosarcoma (2) · Melanoma (2) · Paraganglioma (2) · Perivascular Epithelioid Cell Neoplasms (2) · Pheochromocytoma (2) · Rhabdomyosarcoma (2) · Skin Neoplasms (2) · Vulvar Neoplasms (2)
Adenocarcinoma (14) · Neoplasms by Histologic Type (14) · Neoplasms, Ductal, Lobular, and Medullary (14) · Neoplasms, Glandular and Epithelial (14) · Carcinoma (13) · Neoplasms (13) · Neoplasms by Site (6) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Nerve Tissue (5) · Neuroectodermal Tumors (5) · Neuroendocrine Tumors (5) · Carcinoma, Neuroendocrine (4) · Genital Diseases (4) · Neoplasms, Basal Cell (4) · Neoplasms, Connective and Soft Tissue (4)
Nivolumab (2) · Specimen Handling (2) · Acetaminophen (1) · Biopsy (1) · CTLA-4 Antigen (1) · Fluorescein (1) · Imiquimod (1) · Ipilimumab (1) · Lidocaine (1) · Magnetic Resonance Spectroscopy (1) · bicalutamide (1) · pembrolizumab (1) · talimogene laherparepvec (1) · toripalimab (1)
Fudan University (4) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · Emory University (1) · Fujian Medical University Union Hospital (1) · Mayo Clinic (1) · Sheng Zhang (1) · University Hospital, Lille (1) · University Medical Center Nijmegen (1)
China (6) · United States (6) · France (1) · Guam (1) · Netherlands (1)
Hongxia Wang, Doctor (2) · Jamie N. Bakkum-Gamez, M.D. (1) · Joanne de Hullu, MD PhD (1) · Keith Delman, MD (1) · Lara Dunn, MD (1) · Laurent Mortier, MD,PhD (1) · Mario Leitao, MD (1) · Sandip P Patel (1) · Shaoxing Zhu, Doctor (1)
PMID 28877863, PMID 31793891, PMID 31969335, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34716198, PMID 35447145, PMID 37633576, PMID 38243705, PMID 38358334, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39856213, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41892875, PMID 41995270, PMID 42499790
2018 (1), U10CA180888 (1), UM1CA186709 (1), UM1CA186716 (1)