9 completed, 6 unknown, 3 withdrawn, 2 recruiting. 8 Phase 2, 4 Not applicable, 3 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow Non-small Cell Lung Cancer Stage I: new trials by email Literature Review of Non-small Cell Lung Cancer Stage I trials Research Report on Non-small Cell Lung Cancer Stage I
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nebulized AER101 in Pre-op NSCLC AER101 - Non-small Cell Lung Cancer Stage I, Non-small Cell Lung Cancer Stage II | Early Phase 1 | Not yet recruiting | University of Oklahoma | 5 | 2026-06-01 | 2026-06-08 |
| A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease BIO 300 - NSCLC, NSCLC, Stage I | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 25 | 2026-01-06 | 2026-09-16 |
| Combining ICI With SBRT or HypoFrx-RT for ES NSCLC Stereotactic body radiotherapy, Hypofractionated radiotherapy, Durvalumab - Non-small Cell Lung Cancer, Non-small Cell Carcinoma | Phase 1 / Phase 2 | Unknown | Alexander Chi | 83 | 2023-10-09 | 2023-10-03 |
| SCION: SABR and Checkpoint Inhibition of NSCLC Durvalumab, Stereotactic Body Radiotherapy, Circulating Tumor DNA assay - Non Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung | Phase 2 | Withdrawn | University of British Columbia | 2023-08-11 | 2024-09-03 | |
| Volatolomic and Proteomic Profile for Early Diagnosis of Lung Cancer Breath, urine and blood analysis - Lung Cancer, Non-small Cell Lung Cancer Stage I | Unknown | European Institute of Oncology | 200 | 2023-05-05 | 2024-04-02 | |
| Effect and Long-Term Outcomes of Indocyanine Green Fluorescence Imaging Method Versus Modified Inflation-Deflation Method in Identification of Intersegmental Plane（IMPLANE-0529） Indocyanine green fluorescence imaging method, Modified inflation-deflation method - Segmentectomy, Non-small Cell Lung Cancer Stage I | Not applicable | Completed | The First Affiliated Hospital of Nanchang University | 272 | 2022-08-04 | 2026-05-07 |
| Traditional Chinese Medicine Combined With Thermal and Cold Ablation for Early-stage Lung Cancer traditional Chinese medicine and ablation in the primary tumor sites, ablation - Non-small Cell Lung Cancer Stage I | Not applicable | Unknown | Shanghai 10th People's Hospital | 110 | 2021-11-01 | 2021-10-28 |
| Adjuvant ctDNA-Adapted Personalized Treatment in Early Stage NSCLC (ADAPT-E) AVENIO ctDNA Surveillance Kit, Durvalumab, Durvalumab (Imfinzi) alone or in combination with platinum-based chemotherapy - Non-small Cell Lung Cancer, Non-small Cell Lung Cancer Stage I | Phase 2 | Suspended | Stanford University | 80 | 2021-04-08 | 2026-07-07 |
| Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy Durvalumab, Stereotactic Body Radiation Therapy - NSCLC, Non-small Cell Lung Cancer | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 13 | 2021-01-27 | 2026-05-11 |
| The Canada Lymph Node Score Project: A Crossover Trial Selective Targeted Sampling, Systematic Sampling - Lung Cancer, Non Small Cell Lung Cancer | Phase 3 | Completed | St. Joseph's Healthcare Hamilton | 80 | 2020-11-30 | 2022-07-27 |
| Stereotactic Ablative Radiotherapy With Nivolumab for Early-Stage Operable Non-Small Cell Lung Cancer nivolumab - Non-small Cell Lung Cancer Stage I | Phase 2 | Completed | Hospital Israelita Albert Einstein | 25 | 2020-02-12 | 2023-12-26 |
| Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003) Intra-operative frozen section - Lymph Node Metastases, Non-small Cell Lung Cancer Stage I | Completed | Fudan University | 1076 | 2019-03-14 | 2023-07-20 | |
| Pathologic and Immunologic Response After Ablative Radiation in Lung Cancer Post-SABR Biopsy - Non-small Cell Lung Cancer Stage I | Not applicable | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 6 | 2018-10-16 | 2026-07-02 |
| SBRT With Immunotherapy in Early Stage Non-small Cell Lung Cancer: Tolerability and Lung Effects Stereotactic body radiotherapy, Nivolumab - Non-small Cell Lung Cancer Stage II, Non-small Cell Lung Cancer Stage I | Phase 1 / Phase 2 | Completed | Royal Marsden NHS Foundation Trust | 36 | 2018-02-08 | 2026-07-17 |
| Surgery Versus Stereotactic Body Radiation Therapy for Stage up to IA2 (T1a or T1b) Non-small Cell Lung Cancer Anatomical Segmentectomy, Lobectomy or Bilobectomy, Stereotactic Body Radiation Therapy - Non-small Cell Lung Cancer Stage I, Surgery | Not applicable | Withdrawn | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | 2018-01-28 | 2021-08-24 | |
| ctDNA Dynamic Monitoring and Its Role of Prognosis in Stage I NSCLS by NGS ctDNA detection - Non-small Cell Lung Cancer Stage I | Completed | Sun Yat-sen University | 100 | 2017-07-01 | 2024-09-04 | |
| Oncolytic Adenovirus-Mediated Gene Therapy for Lung Cancer Ad5-yCD/mutTKSR39rep-ADP Adenovirus - Non-small Cell Lung Cancer Stage I | Phase 1 | Withdrawn | Benjamin Movsas, M.D. | 2017-01-13 | 2019-08-13 | |
| Segmentectomy vs Lobectomy Non-small Cell Lung Cancer Stage I, Surgery | Unknown | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 800 | 2017-01-01 | 2023-12-22 | |
| Clinical Research Platform Into Molecular Testing, Treatment and Outcome of (Non-)Small Cell Lung Carcinoma Patients data collection - Metastatic Non-small Cell Lung Cancer (NSCLC), Non-small Cell Lung Cancer Metastatic | Recruiting | AIO-Studien-gGmbH | 14500 | 2015-12-01 | 2026-10-09 | |
| LungTech: Stereotactic Body Radiotherapy (SBRT) of Inoperable Centrally Located NSCLC Stereotactic Body Radiotherapy (SBRT) - Non-small Cell Lung Cancer Stage I, Non-small Cell Lung Cancer Stage II | Phase 2 | Unknown | European Organisation for Research and Treatment of Cancer - EORTC | 39 | 2015-08-01 | 2020-01-31 |
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Carcinoma, Non-Small-Cell Lung (23) · Lung Neoplasms (5) · Adenocarcinoma of Lung (2) · Adenoviridae Infections (1) · Disease (1) · Lung Diseases, Interstitial (1) · Lymphatic Metastasis (1) · Neoplasm, Residual (1) · Neoplasms (1) · Parkinson Disease 4, Autosomal Dominant Lewy Body (1) · Small Cell Lung Carcinoma (1)
Bronchial Neoplasms (23) · Carcinoma, Bronchogenic (23) · Lung Diseases (23) · Neoplasms by Site (23) · Respiratory Tract Diseases (23) · Respiratory Tract Neoplasms (23) · Thoracic Neoplasms (23) · Neoplasms (22) · Lung Neoplasms (18) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Adenocarcinoma (2) · Carcinoma (2) · Neoplasms by Histologic Type (2) · Neoplasms, Glandular and Epithelial (2)
Radiosurgery (6) · durvalumab (4) · Nivolumab (2) · Data Collection (1) · Hematologic Tests (1) · Medicine, Chinese Traditional (1) · Platinum Compounds (1) · Radiation Dose Hypofractionation (1) · Single Person (1) · Urination (1)
Memorial Sloan Kettering Cancer Center (2) · AIO-Studien-gGmbH (1) · Alexander Chi (1) · Benjamin Movsas, M.D. (1) · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec (1) · European Institute of Oncology (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Fudan University (1) · Hospital Israelita Albert Einstein (1) · Hunan Province Tumor Hospital (1) · Royal Marsden NHS Foundation Trust (1) · Shanghai 10th People's Hospital (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · St. Joseph's Healthcare Hamilton (1)
China (7) · United States (6) · Canada (3) · Germany (2) · Italy (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Switzerland (1)
Alexander Chi, MD (1) · Charles Simone, MD (1) · Frank Griesinger, Prof. Dr. (1) · Gustavo Schvartsman, MD, PhD (1) · Haiquan Chen, MD,PhD (1) · Islam Mohamed, MD (1) · Jian Tang, M.D., Ph.D (1) · Jianxing He, MD (1) · Joel W Neal, MD,PhD (1) · Khinh Ranh Voong, MD (1) · Matthew Reinersman, MD (1) · Merina Ahmed (1) · Narek Shaverdian, MD (1) · Nong Yang, MD (1)
PMID 22590666, PMID 26104945, PMID 32623075, PMID 33358484, PMID 34567289, PMID 36180086, PMID 37981101, PMID 38329180