31 completed, 7 recruiting, 7 unknown, 5 terminated. 52 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 52 | Completed 31, Recruiting 7, Unknown 7, Terminated 5, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 5 | Recruiting 2, Terminated 2, Completed 1 |
Follow Neuroblastoma: new trials by email Literature Review of Neuroblastoma trials Research Report on Neuroblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and Ganglioneuroblastoma Dinutuximab beta, temozolomide, irinotecan, autologous NK cell, irinotecan, temozolomide, dinutuximab beta, NK-cell product - Neuroblastoma (NB), Ganglioneuroblastoma | Phase 3 | Recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 5 | 2025-11-19 | 2026-01-29 |
| DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations Capmatinib - Solid Tumour, Haematological Malignancy | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2024-11-19 | 2025-11-24 |
| Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Ganglioneuroblastoma, Nodular, Neuroblastoma | Phase 3 | Recruiting | National Cancer Institute (NCI) | 478 | 2024-04-19 | 2026-10-27 |
| DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers Alectinib - Haematological Malignancy, Malignant Neoplasm | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2023-12-18 | 2025-11-24 |
| Induction Chemoimmunotherapy for Patients With High-risk Neuroblastoma monoclonal antibodies GD2 - Neuroblastoma, Ganglioneuroblastoma | Phase 3 | Recruiting | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 15 | 2023-09-01 | 2023-10-10 |
| Open-Label Study of 18F-mFBG for Imaging Neuroblastoma 18F-MFBG - Neuroblastoma | Phase 3 | Completed | Innervate Radiopharmaceuticals LLC (Formerly: Illumina Radiopharmaceuticals LLC) | 43 | 2021-11-18 | 2026-09-29 |
| 18F-DOPA II - PET Imaging Optimization 18F-DOPA, Furosemide Injection - Congenital Hyperinsulinism, Neuroblastoma | Phase 3 | Recruiting | University of Alberta | 800 | 2021-01-20 | 2026-02-09 |
| 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases 131I-omburtamab - Neuroblastoma, CNS Metastases | Phase 2 / Phase 3 | Terminated | Y-mAbs Therapeutics | 52 | 2018-12-11 | 2024-02-13 |
| Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) Autologous Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Aspiration and Biopsy - Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular | Phase 3 | Recruiting | Children's Oncology Group | 750 | 2018-05-14 | 2026-08-25 |
| 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety 18F-DOPA - Congenital Hyperinsulinism, Neuroblastoma | Phase 3 | Completed | University of Alberta | 400 | 2017-06-29 | 2022-01-10 |
| Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Biopsy Procedure, Bone Marrow Aspiration, Bone Marrow Biopsy - Ganglioneuroblastoma, Localized Resectable Neuroblastoma | Phase 3 | Active not recruiting | Children's Oncology Group | 391 | 2014-08-08 | 2026-10-13 |
| Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer filgrastim - Childhood Choroid Plexus Tumor, Childhood Medulloblastoma | Phase 3 | Terminated | Barbara Ann Karmanos Cancer Institute | 23 | 2013-08-01 | 2020-10-29 |
| Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg)Opsoclonus Myoclonus Syndrome/Dancing Eye Syndrome (OMS/DES) in Children With and Without Neuroblastoma (NBpos and NBneg) Dexamethasone acetate, dexamethasone and cyclophosphamide, dexamethasone and rituximab - Opsoclonus Myoclonus Syndrome, Neuroblastoma | Phase 3 | Completed | Institut Curie | 102 | 2013-04-18 | 2025-02-03 |
| European Low and Intermediate Risk Neuroblastoma Protocol chemotherapy - LOW AND INTERMEDIATE PAEDIATRIC NEUROBLASTOMA AND NEONATAL SUPRARENAL MASSES | Phase 3 | Completed | Instituto de Investigacion Sanitaria La Fe | 685 | 2011-01-01 | 2023-09-08 |
| Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy doxepin hydrochloride, placebo - Head and Neck Cancer, Mucositis | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 155 | 2010-12-01 | 2017-08-09 |
| Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer cyproheptadine hydrochloride, placebo - Cancer | Phase 3 | Terminated | University of South Florida | 22 | 2010-06-01 | 2015-07-02 |
| Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy sodium thiosulfate, examination - Brain Tumor, Central Nervous System Tumor | Phase 3 | Completed | Children's Oncology Group | 131 | 2008-06-23 | 2023-11-09 |
| A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families educational intervention, informational intervention, internet-based intervention - Chronic Myeloproliferative Disorders, Leukemia | Phase 3 | Completed | Tufts Medical Center | 198 | 2008-06-01 | 2011-07-13 |
| Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma Autologous Hematopoietic Stem Cell Transplantation, Carboplatin, Cisplatin - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Phase 3 | Completed | Children's Oncology Group | 665 | 2007-11-05 | 2022-04-28 |
| Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma carboplatin, cyclophosphamide, doxorubicin hydrochloride - Neuroblastoma | Phase 3 | Completed | Children's Oncology Group | 464 | 2007-10-08 | 2021-07-06 |
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Neoplasms (10) · Testicular Neoplasms (10) · Blast Crisis (9) · Breast Neoplasms (9) · Burkitt Lymphoma (9) · Leukemia, Myeloid, Accelerated Phase (9) · Leukemia, Myeloid, Chronic-Phase (9) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (9) · Primary Myelofibrosis (9) · Carcinoma, Ovarian Epithelial (8) · Esthesioneuroblastoma, Olfactory (8) · Hodgkin Disease (8) · Leukemia, Hairy Cell (8) · Leukemia, Lymphocytic, Chronic, B-Cell (8)
Neoplasms, Germ Cell and Embryonal (52) · Neoplasms, Glandular and Epithelial (52) · Neoplasms, Nerve Tissue (52) · Neuroectodermal Tumors (52) · Neoplasms, Neuroepithelial (51) · Neuroectodermal Tumors, Primitive (51) · Neoplasms by Histologic Type (50) · Neuroectodermal Tumors, Primitive, Peripheral (50) · Neoplasms (42) · Neoplasms by Site (22) · Carcinoma (16) · Pathological Conditions, Signs and Symptoms (16) · Nervous System Diseases (15) · Female Urogenital Diseases (14) · Female Urogenital Diseases and Pregnancy Complications (14)
Cyclophosphamide (21) · Carboplatin (18) · Etoposide (16) · Doxorubicin (14) · Vincristine (13) · Cisplatin (11) · Melphalan (11) · Filgrastim (10) · Radiotherapy (10) · Isotretinoin (8) · Topotecan (7) · Granulocyte Colony-Stimulating Factor (6) · Peripheral Blood Stem Cell Transplantation (6) · dinutuximab (5) · sargramostim (5)
Children's Oncology Group (9) · Children's Cancer and Leukaemia Group (4) · Fred Hutchinson Cancer Center (3) · Alliance for Clinical Trials in Oncology (2) · Cancer Research UK (2) · Federal Research Institute of Pediatric Hematology, Oncology and Immunology (2) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · University of Alberta (2) · Barbara Ann Karmanos Cancer Institute (1) · Children's Hospital Medical Center, Cincinnati (1) · Daiichi Sankyo (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · GE Healthcare (1) · German Society for Pediatric Oncology and Hematology GPOH gGmbH (1)
United States (31) · Canada (14) · Australia (11) · Switzerland (9) · Puerto Rico (8) · New Zealand (7) · Spain (7) · United Kingdom (7) · Italy (6) · Sweden (6) · Austria (5) · Belgium (5) · Denmark (5) · France (5) · Germany (5)
Andrew David J. Pearson, MD, FRCP, DCh (2) · Ann Barrett (2) · Frank Berthold, MD (2) · Janice A. Kohler, MD, FRCP (2) · Matthew Krebs, Dr (2) · Alice L Yu (1) · Andrea di Cataldo (1) · Arnold F Jacobson, MD, PhD (1) · Arnold M. Markoe, MD, ScD (1) · Charles Ross Pinkerton, MD (1) · Clare Twist, MD (1) · Daniel Worsley, MD (1) · David G. Pfister, MD (1) · David L. Baker, MD, MBBS, FRACP, FRCPA (1)
PMID 20567002, PMID 10882162, PMID 11464889, PMID 12101494, PMID 12165894, PMID 12880954, PMID 12932669, PMID 15459300, PMID 16129365, PMID 18308250, PMID 20406930, PMID 20879880, PMID 20879881, PMID 21328522, PMID 22480131, PMID 22529259, PMID 22742881, PMID 23281263, PMID 23890779, PMID 24419114, PMID 24590653, PMID 24733799, PMID 27020837, PMID 27465021, PMID 27914822, PMID 28259608, PMID 29120699, PMID 29376112, PMID 29755120, PMID 30015396, PMID 30442501, PMID 30444686, PMID 31386611, PMID 31454045, PMID 32013055, PMID 32530765, PMID 32639845, PMID 34028986, PMID 34115544, PMID 35839426, PMID 37883734, PMID 38464207, PMID 39083105, PMID 40036726, PMID 41073929
U10CA180886 (6), U10CA098543 (4), P30CA008748 (1), P30CA022453 (1), P30CA069533 (1), R01CA107080 (1), R01CA119196 (1), R21CA098792 (1), U10CA013539 (1), U10CA030969 (1), U10CA037404 (1), U10CA081920 (1)