36 completed, 22 unknown, 15 recruiting, 6 terminated. 90 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 90 | Completed 36, Unknown 22, Recruiting 15, Terminated 6, Withdrawn 5, Not yet recruiting 4, Active not recruiting 2 |
Follow Nephritis: new trials by email Literature Review of Nephritis trials Research Report on Nephritis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Obinutuzumab Beta in Primary IgA Nephropathy With Active Pathological Lesions Obinutuzumab Beta - Primary IgA Nephropathy | Phase 4 | Not yet recruiting | Ruijin Hospital | 20 | 2026-12-10 | 2026-10-22 |
| Mechanistic Evaluation of Atrasentan in Patients With IgA Nephropathy (IgAN) atrasentan - IgA Nephropathy (IgAN), Immunoglobulin A Nephropathy (IgAN) | Phase 4 | Not yet recruiting | University of Illinois at Chicago | 20 | 2026-09-29 | 2026-09-21 |
| Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study Pegcetacoplan - C3 Glomerulopathy (C3G), Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN) | Phase 4 | Recruiting | Swedish Orphan Biovitrum | 150 | 2026-08-05 | 2026-09-09 |
| Childhood-onset Lupus Nephritis Initial Glucocorticoid-dose Harmonization Trial (LIGHT Trial) High-dose prednisone, Low-dose prednisone - Childhood-onset Systemic Lupus Erythematosus, Lupus Nephritis (LN) | Phase 4 | Recruiting | Peking Union Medical College Hospital | 198 | 2026-07-01 | 2026-07-22 |
| Efficacy and Safety of Nefecon on Prevention of Relapse of IgA Nephropathy NEFECON, Placebo - IgA Nephropathy (IgAN) | Phase 4 | Recruiting | Nanfang Hospital, Southern Medical University | 288 | 2026-06-23 | 2026-09-02 |
| Dapagliflozin in Active Lupus Nephritis Dapagliflozin (10Mg Tab) along with standard medical therapy, Placebo - Lupus Nephritis (LN) | Phase 4 | Recruiting | Brigham and Women's Hospital | 33 | 2026-05-19 | 2026-05-26 |
| Assessing Residual Inflammation and Macrophage Presence in Lupus Nephritis After 3 Months of Intensified Treatment With Prednisolone, Mycofenolate Mofetil and Voclosporin as Compared to Mycofenolate Mofetil and Prednisolone Kidney Biopsy, Voclosporin (LUPKYNIS), Blood, feces and urine sample collection - Lupus Nephritis, Systemic Lupus Erythematosus (SLE) | Phase 4 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 55 | 2026-04-23 | 2026-08-12 |
| PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis LUPKYNIS, belimumab, obinutuzumab or anifrolumab, mycophenolic acid analog (MPAA) - Lupus Nephritis | Phase 4 | Recruiting | Aurinia Pharmaceuticals Inc. | 150 | 2026-04-22 | 2026-08-03 |
| Sparsentan in Posttransplant Immunoglobulin A Nephropathy or Focal Segmental Glomerulosclerosis Sparsentan - Proteinuria, Immunoglobulin A (IgA) Nephropathy | Phase 4 | Active not recruiting | Travere Therapeutics, Inc. | 20 | 2025-10-07 | 2026-06-23 |
| Nefecon and Ambrisentan in IgA Nephropathy "Nefecon®","Ambrisentan" - IgA Nephropathy, Chronic Kidney Disease | Phase 4 | Recruiting | The First Hospital of Jilin University | 129 | 2025-09-01 | 2025-09-15 |
| SGLT-2 Inhibitors on Albuminuria in Chronic Kidney Disease Patients With Lupus Nephritis and ANCA- Associated Vasculitis Gliflozin - Lupus Nephritis (LN), ANCA Associated Vasculitis (AAV) | Phase 4 | Not yet recruiting | Federico II University | 40 | 2025-09-01 | 2025-06-25 |
| Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate at Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (≥18 Years) Primary IgA Nephropathy? Oral prednisolone and SoC, Gut-directed budesonide and SoC, Mycophenolate mofetil (MMF) and SoC - IgA Nephropathy, Renal Insufficiency, Chronic | Phase 4 | Recruiting | Christian Medical College, Vellore, India | 585 | 2025-02-15 | 2025-07-14 |
| Efficacy and Safety of Extended TARPEYO® Treatment Beyond 9 Months in Adult Patients With Primary IgA Nephropathy TARPEYO® - IgA Nephropathy | Phase 4 | Active not recruiting | Calliditas Therapeutics AB | 60 | 2024-12-17 | 2026-09-24 |
| Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of Proliferative Forms of Lupus Glomerulopathy: Synergy Trial Voclosporin - Lupus Nephritis | Phase 4 | Recruiting | NephroNet, Inc. | 30 | 2024-10-01 | 2025-11-06 |
| Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis Cefuroxime, Cefuroxime Axetil - Pyelonephritis in Pregnancy | Phase 4 | Recruiting | Hospital de Clinicas de Porto Alegre | 100 | 2024-09-09 | 2024-09-19 |
| Efficacy and Safety of Probiotics Combined With Enteric-coated Budesonide Capsules in Patients With Primary IgA Nephropathy probiotics combined with enteric-coated budesonide capsule, probiotics placebo combined with enteric-coated budesonide capsules - Glomerulonephritis, IGA, Probiotics | Phase 4 | Not yet recruiting | Gang Xu | 206 | 2024-07-01 | 2024-07-30 |
| Albuminuria Lowering Effect of Dapagliflozin, Spironolactone and Their Combination in Adult Patients With Alport Syndrome (COMBINE-ALPORT) Treatment with Spironolactone followed by Dapagliflozin followed by their combination, Treatment with Dapagliflozin followed by Spironolactone followed by their combination - Alport Syndrome, Thin Basement Membrane Disease | Phase 4 | Completed | Stefan Lujinschi | 12 | 2024-02-26 | 2026-06-25 |
| The Efficacy of Empagliflozin on Kidney Functions in Lupus Nephritis Population Empagliflozin (25 Mg Tab) along with standard medical therapy, Placebo and standard of care - Lupus Nephritis (LN) | Phase 4 | Recruiting | Ahmed Yehia Ismail | 66 | 2024-01-22 | 2026-07-15 |
| Rivaroxaban in Idiopathic Membranous Nephropathy Rivaroxaban 10 MG, Warfarin Sodium - Idiopathic Membranous Nephropathy | Phase 4 | Recruiting | Beijing Friendship Hospital | 134 | 2024-01-05 | 2026-02-11 |
| Comparing Mescaline Sodium Enteric-coated Tablets vs Morte-mescaline in the Treatment of Adult Lupus Nephritis Mescaline sodium enteric-coated tablets, Morte-mescaline, Glucocorticoids - Lupus Nephritis | Phase 4 | Unknown | Xiangya Hospital of Central South University | 205 | 2023-07-06 | 2023-07-06 |
Showing 20 of 90. Sign in to see all of them.
Glomerulonephritis, IGA (32) · Lupus Nephritis (29) · Proteinuria (22) · Glomerulonephritis (17) · Glomerulonephritis, Membranous (10) · Renal Insufficiency, Chronic (9) · Pyelonephritis (8) · Lupus Erythematosus, Systemic (7) · Kidney Diseases (5) · Nephrotic Syndrome (5) · Glomerulosclerosis, Focal Segmental (4) · Albuminuria (2) · Autoimmune Diseases (2) · Cystitis (2)
Female Urogenital Diseases (90) · Female Urogenital Diseases and Pregnancy Complications (90) · Male Urogenital Diseases (90) · Urogenital Diseases (90) · Urologic Diseases (89) · Kidney Diseases (85) · Immune System Diseases (70) · Autoimmune Diseases (68) · Glomerulonephritis (61) · Skin and Connective Tissue Diseases (33) · Connective Tissue Diseases (31) · Pathological Conditions, Signs and Symptoms (30) · Signs and Symptoms (25) · Urination Disorders (24)
Mycophenolic Acid (15) · Prednisolone (8) · Tacrolimus (8) · Adrenal Cortex Hormones (5) · Cyclophosphamide (5) · dapagliflozin (5) · Losartan (4) · Prednisone (4) · Rituximab (4) · Adrenocorticotropic Hormone (3) · Anti-Bacterial Agents (3) · Calcitriol (3) · Hydroxychloroquine (3) · Valsartan (3) · aliskiren (3)
Guangdong Provincial People's Hospital (5) · Chinese University of Hong Kong (4) · Columbia University (3) · Astellas Pharma Korea, Inc. (2) · Chinese PLA General Hospital (2) · Chulalongkorn University (2) · Mansoura University (2) · Peking Union Medical College Hospital (2) · Peking University First Hospital (2) · The Rogosin Institute (2) · The University of Hong Kong (2) · Tuen Mun Hospital (2) · Yonsei University (2) · A. Manzoni Hospital (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1)
China (29) · United States (19) · Italy (5) · South Korea (5) · Canada (4) · Egypt (4) · France (4) · Hong Kong (3) · Belgium (2) · Germany (2) · India (2) · Romania (2) · Switzerland (2) · Thailand (2) · United Kingdom (2)
Cheuk-Chun Szeto, MD (3) · Choli Hartono, MD (2) · Akwugo A Eziefule, MD (1) · Anand Srivastava, MD, MPH (1) · Anca D Askanase, MD, MPH (1) · Antonello Pani, MD (1) · Brad H Rovin, MD (1) · CC Mok, MD, FRCP (1) · Claudio Ponticelli, MD (1) · Claudio Pozzi, MD (1)
PMID 38299639, PMID 34778952, PMID 26032537, PMID 26630142, PMID 28763548, PMID 29450636, PMID 10093981, PMID 11511139, PMID 12209517, PMID 1356175, PMID 15851648, PMID 16014059, PMID 16164651, PMID 17377504, PMID 17533019, PMID 17978307, PMID 18436082, PMID 18490378, PMID 18930568, PMID 19369404, PMID 19571790, PMID 19571791, PMID 19628647, PMID 20220333, PMID 2023605, PMID 2142748, PMID 21606384, PMID 21626222, PMID 21677438, PMID 21680850, PMID 21852672, PMID 22075320, PMID 22291112, PMID 22371643, PMID 22722778, PMID 22995802, PMID 23150796, PMID 23449768, PMID 23689577, PMID 24009220, PMID 24029421, PMID 24189358, PMID 24191893, PMID 24375637, PMID 24641955, PMID 25018935, PMID 25480673, PMID 25550339, PMID 25585823, PMID 25677392
2025 (2), 2008 (1), 2009 (1), 2014 (1), 2016 (1)