73 completed, 19 recruiting, 17 unknown, 14 terminated. 49 Phase 2, 18 Not applicable, 14 Phase 1, 14 Phase 3, 2 Phase 4.
Follow Mast Cell Activation Disorders: new trials by email Literature Review of Mast Cell Activation Disorders trials Research Report on Mast Cell Activation Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration - Acute Biphenotypic Leukemia, Acute Leukemia | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 52 | 2027-01-01 | 2026-09-14 |
| Precision Medicine for Indolent Systemic Mastocytosis (PRISM) Systemic Mastocytosis | Not yet recruiting | Mayo Clinic | 25 | 2026-09-09 | 2026-08-18 | |
| An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM) Indolent Systemic Mastocytosis | Recruiting | Blueprint Medicines Corporation | 150 | 2026-04-15 | 2026-09-04 | |
| Is Swimming a More Tolerable Form of Movement for Individuals With Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome? Swimming, Cycling - ME/CFS, Long COVID | Not applicable | Suspended | Simon Fraser University | 50 | 2026-02-20 | 2026-03-30 |
| A Non-Interventional Study in Participants With Indolent Systemic Mastocytosis (ISM) in Germany Avapritinib - Indolent Systemic Mastocytosis | Recruiting | Blueprint Medicines Corporation | 80 | 2025-12-09 | 2026-10-07 | |
| Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations Screening - Clonal Mast Cell Disease, KIT D816V Mutation | Recruiting | Blueprint Medicines Corporation | 750 | 2025-10-17 | 2026-10-07 | |
| Peripheral Blood KIT-D816V Mutation in Adult Systemic Mastocytosis Systemic Mastocytosis, KIT-D816V Mutation | Recruiting | The First Affiliated Hospital of Soochow University | 50 | 2025-05-19 | 2026-05-01 | |
| Analysis of the Role of IgE Proteoforms in Health and Disease Blood sample collection - Anaphylaxis, Mastocytosis | Recruiting | KU Leuven | 200 | 2025-01-01 | 2026-01-09 | |
| Avapritinib Rollover Study Avapritinib - Mastocytosis, Systemic | Phase 4 | Recruiting | Blueprint Medicines Corporation | 60 | 2024-11-28 | 2026-02-09 |
| Epidemiological Data on Mast Cell Pathologies in France Mast Cell Disorder | Recruiting | Imagine Institute | 13000 | 2024-11-01 | 2026-04-22 | |
| Institutional Registry of Rare Diseases Rare Diseases, Amyloidosis | Recruiting | Hospital Italiano de Buenos Aires | 380 | 2024-07-01 | 2026-01-14 | |
| Mastocytosis Registry (of Zurich) Mastocytosis, Hypertryptasemia | Recruiting | University of Zurich | 400 | 2024-06-06 | 2024-06-26 | |
| Study of Cellular Heterogeneity in Patients With Mastocytosis scRNAseq, two Skin biopsies, one Skin biopsies - Mastocytosis | Not applicable | Unknown | University Hospital, Toulouse | 26 | 2024-06-01 | 2024-05-29 |
| Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves NeuroTears, Placebo - Dry Eye Disease, Dry Eye | Not applicable | Unknown | Genetic Disease Investigators | 75 | 2024-04-01 | 2024-02-21 |
| Quality of Life and Disease-related Symptoms in Individuals With Systemic Mastocytosis No intervention - Mastocytosis, Systemic | Active not recruiting | Uppsala University | 400 | 2024-03-25 | 2025-04-04 | |
| Mastocytosis From Pediatric Age to Adulthood: Local Registry of Cutaneous and Systemic Mastocytosis Cutaneous Mastocytosis, Systemic Mastocytosis | Recruiting | Fondazione IRCCS Policlinico San Matteo di Pavia | 600 | 2024-01-26 | 2025-08-26 | |
| Angioedema Biomarker Research Study Venipuncture - Angioedema, Angioedemas, Hereditary | Recruiting | Foundation For Rare Disease Research | 600 | 2024-01-15 | 2026-08-24 | |
| Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies BLU-263, Azacitidine - Advanced Systemic Mastocytosis | Phase 1 | Terminated | Blueprint Medicines Corporation | 9 | 2023-09-25 | 2025-04-10 |
| A Registry for Patients With Systemic Mastocytosis in China Systemic Mastocytoses | Unknown | The First Affiliated Hospital of Soochow University | 150 | 2023-09-01 | 2023-10-10 | |
| Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research Post-Acute COVID-19 Syndrome, ME/CFS | Recruiting | Brain Inflammation Collaborative | 10000 | 2023-07-05 | 2026-01-22 |
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Leukemia, Mast-Cell (60) · Mastocytosis, Systemic (53) · Mastocytosis (49) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (44) · Leukemia, Biphenotypic, Acute (42) · Leukemia, Myelomonocytic, Chronic (41) · Leukemia, Hairy Cell (40) · Leukemia, Myeloid, Acute (40) · Leukemia, Lymphocytic, Chronic, B-Cell (39) · Leukemia, Large Granular Lymphocytic (37) · Burkitt Lymphoma (35) · Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (34) · Lymphoma, Large-Cell, Anaplastic (34) · Lymphoma, T-Cell, Cutaneous (34) · Mycosis Fungoides (34)
Immune System Diseases (141) · Neoplasms by Histologic Type (136) · Neoplasms (127) · Neoplasms, Connective and Soft Tissue (95) · Neoplasms, Connective Tissue (94) · Mastocytosis (87) · Hemic and Lymphatic Diseases (81) · Hematologic Diseases (75) · Leukemia, Myeloid (68) · Pathological Conditions, Signs and Symptoms (66) · Neoplasms by Site (60) · Pathologic Processes (60) · Disease Attributes (59) · Chronic Disease (56)
Whole-Body Irradiation (7) · fludarabine phosphate (7) · Mycophenolic Acid (6) · Cyclosporine (5) · Peripheral Blood Stem Cell Transplantation (5) · Therapeutics (5) · avapritinib (5) · masitinib (5) · Imatinib Mesylate (4) · Psychiatric Rehabilitation (4) · midostaurin (4) · Busulfan (3) · Cyclophosphamide (3) · Diphenhydramine (3) · fludarabine (3)
Blueprint Medicines Corporation (11) · National Institute of Allergy and Infectious Diseases (NIAID) (9) · M.D. Anderson Cancer Center (8) · University Hospital, Toulouse (7) · Fred Hutchinson Cancer Center (6) · AB Science (5) · Novartis Pharmaceuticals (5) · Assistance Publique - Hôpitaux de Paris (4) · City of Hope Medical Center (4) · Mayo Clinic (4) · Wake Forest University Health Sciences (4) · Cogent Biosciences, Inc. (3) · Jason Robert Gotlib (3) · National Cancer Institute (NCI) (3) · UNC Lineberger Comprehensive Cancer Center (3)
United States (84) · France (29) · Germany (19) · Italy (15) · Canada (13) · Netherlands (13) · Spain (13) · United Kingdom (13) · Belgium (11) · Norway (9) · Poland (9) · Australia (8) · Switzerland (8) · Austria (7) · Denmark (4)
Jorge Cortes, MD (3) · Olivier Lortholary, MD, PhD (3) · Srdan Verstovsek, MD (3) · Cristina Bulai Livideanu, MD (2) · David Maloney (2) · Elisabeth Paietta, PhD (2) · Frank Siebenhaar, MD (2) · Hirsh D Komarow, M.D. (2) · Jason Gotlib (2) · Kyoo H. Lee, MD (2) · Luis Escribano, MD, PhD (2) · Marcus Maurer, MD (2) · Melody C Carter, M.D. (2) · Rachael Easton, MD, PhD (2)
PMID 35790816, PMID 21134978, PMID 27355533, PMID 32499241, PMID 35640224, PMID 36048877, PMID 15070706, PMID 16775235, PMID 17715389, PMID 18327587, PMID 18567837, PMID 18698002, PMID 19451433, PMID 20004787, PMID 21098399, PMID 21108325, PMID 21523798, PMID 22259028, PMID 22563089, PMID 22892471, PMID 23432617, PMID 23547655, PMID 24057647, PMID 24150753, PMID 24474568, PMID 25605272, PMID 26002753, PMID 26175532, PMID 26476479, PMID 26700120, PMID 26700123, PMID 28069279, PMID 28744009, PMID 29890238, PMID 30205939, PMID 31350306, PMID 32437738, PMID 32804590, PMID 33049057, PMID 34663404, PMID 34873345, PMID 34873347, PMID 35015828, PMID 35251038, PMID 35622074, PMID 35816681, PMID 38261392, PMID 38320129, PMID 38837707, PMID 39425617
P30CA015704 (5), P01CA018029 (3), 2016 (2), P30CA015083 (2), P30CA016086 (2), P30CA033572 (2), P30CA068485 (2), P30CA072720 (2), 2008 (1), 2015 (1), 2017 (1), 2018 (1), N01CM62202 (1), P01CA049605 (1), P01CA078902 (1)