12 completed, 1 active not recruiting. 4 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 3, Active not recruiting 1 |
| Phase 1 | 3 | Completed 3 |
Follow Localized Unresectable Neuroblastoma: new trials by email Literature Review of Localized Unresectable Neuroblastoma trials Research Report on Localized Unresectable Neuroblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk Neuroblastoma Biopsy Procedure, Bone Marrow Aspiration, Bone Marrow Biopsy - Ganglioneuroblastoma, Localized Resectable Neuroblastoma | Phase 3 | Active not recruiting | Children's Oncology Group | 391 | 2014-08-08 | 2026-10-13 |
| Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin 3-Dimensional Conformal Radiation Therapy, Autologous Hematopoietic Stem Cell Transplantation, Busulfan - Ganglioneuroblastoma, Localized Resectable Neuroblastoma | Phase 1 | Completed | Children's Oncology Group | 99 | 2011-12-21 | 2026-01-23 |
| Pharmacokinetics of Ch14.18 in Younger Patients With High-Risk Neuroblastoma Cytology Specimen Collection Procedure, Pharmacological Study - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Completed | National Cancer Institute (NCI) | 12 | 2011-05-26 | 2019-10-01 | |
| Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma diagnostic laboratory biomarker analysis - Disseminated Neuroblastoma, Localized Resectable Neuroblastoma | Completed | Children's Oncology Group | 90 | 2011-05-01 | 2015-05-12 | |
| Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma Isotretinoin, Laboratory Biomarker Analysis, Pharmacological Study - Localized Unresectable Neuroblastoma, Recurrent Neuroblastoma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2010-12-01 | 2015-11-24 |
| Study of Specimens From Young Patients With Neuroblastoma laboratory biomarker analysis - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Completed | Children's Oncology Group | 350 | 2008-12-01 | 2016-05-18 | |
| Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma Autologous Hematopoietic Stem Cell Transplantation, Carboplatin, Cisplatin - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Phase 3 | Completed | Children's Oncology Group | 665 | 2007-11-05 | 2022-04-28 |
| Study of DNA in Blood Samples From Patients With Neuroblastoma laboratory biomarker analysis, polymerase chain reaction, polyacrylamide gel electrophoresis - Disseminated Neuroblastoma, Localized Resectable Neuroblastoma | Completed | Children's Oncology Group | 329 | 2007-06-01 | 2016-05-18 | |
| Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions Laboratory Biomarker Analysis - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Completed | Children's Oncology Group | 9350 | 2006-12-11 | 2018-08-07 | |
| Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma Clinical Observation, Cyclophosphamide, Laboratory Biomarker Analysis - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Phase 3 | Completed | Children's Oncology Group | 53 | 2004-03-15 | 2023-04-18 |
| R(+)XK469 in Treating Patients With Advanced Neuroblastoma R(+)XK469 - Disseminated Neuroblastoma, Localized Unresectable Neuroblastoma | Phase 1 | Completed | National Cancer Institute (NCI) | 85 | 2001-12-01 | 2013-12-16 |
| Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma Aldesleukin, Dinutuximab, Isotretinoin - Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma | Phase 3 | Completed | National Cancer Institute (NCI) | 1449 | 2001-10-26 | 2026-03-05 |
| Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis - Ganglioneuroblastoma, Localized Resectable Neuroblastoma | Completed | Children's Oncology Group | 10000 | 2000-11-06 | 2026-07-09 |
Neuroblastoma (12) · Ganglioneuroblastoma (3) · Neurotoxicity Syndromes (1) · Pain (1)
Neoplasms (12) · Neoplasms by Histologic Type (12) · Neoplasms, Germ Cell and Embryonal (12) · Neoplasms, Glandular and Epithelial (12) · Neoplasms, Nerve Tissue (12) · Neoplasms, Neuroepithelial (12) · Neuroectodermal Tumors (12) · Neuroectodermal Tumors, Primitive (12) · Neuroectodermal Tumors, Primitive, Peripheral (12) · Chemically-Induced Disorders (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Poisoning (1) · Signs and Symptoms (1)
Cyclophosphamide (4) · Isotretinoin (4) · Doxorubicin (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Carboplatin (2) · Cisplatin (2) · Etoposide (2) · Magnetic Resonance Spectroscopy (2) · Melphalan (2) · Observation (2) · Platinum (2) · Topotecan (2) · Vincristine (2) · Watchful Waiting (2) · 3-Iodobenzylguanidine (1)
Children's Oncology Group (9) · National Cancer Institute (NCI) (4)
United States (13) · Canada (6) · Australia (5) · New Zealand (4) · Puerto Rico (4) · Saudi Arabia (2) · Switzerland (2) · Netherlands (1)
Michael Hogarty, MD (2) · Aaron Sugalski, MD (1) · Alice L Yu (1) · Brian D Weiss (1) · Frank M Balis (1) · Holly J Meany (1) · John Maris (1) · Julie Park (1) · Julie R Park (1) · Michael Hogarty (1) · Pedro A De Alarcon (1) · Susan Cohn (1)
PMID 20879881, PMID 29376112, PMID 31454045, PMID 32530765, PMID 34028986, PMID 35839426, PMID 37883734, PMID 38815188, PMID 40036726, PMID 42487567
U10CA098543 (7), U10CA180886 (6), P01CA081403 (1), P30CA016520 (1), U01CA069852 (1), U10CA013539 (1), U10CA030969 (1), UG1CA189958 (1)