26 completed, 5 terminated, 3 unknown. 19 Phase 2, 12 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 16, Unknown 2, Terminated 1 |
| Phase 1 | 12 | Completed 10, Terminated 2 |
| Phase 3 | 3 | Terminated 2, Completed 1 |
Follow Intraocular Melanoma: new trials by email Literature Review of Intraocular Melanoma trials Research Report on Intraocular Melanoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Temozolomide and Bevacizumab in Treating Patients With Metastatic Melanoma of the Eye bevacizumab, temozolomide, polymorphism analysis - Intraocular Melanoma | Phase 2 | Unknown | Institut Curie | 35 | 2009-10-01 | 2013-08-26 |
| Study of Tumor Samples in Patients Undergoing Radiation Therapy or Surgery For Primary Melanoma of the Eye fluorescence in situ hybridization, laboratory biomarker analysis, fine-needle aspiration - Intraocular Melanoma | Completed | Case Comprehensive Cancer Center | 150 | 2009-03-01 | 2015-01-30 | |
| Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Peptide vaccine, GM-CSF, PF3512676 - Intraocular Melanoma, Malignant Conjunctival Neoplasm | Phase 1 | Completed | Ahmad Tarhini | 22 | 2008-10-01 | 2017-06-22 |
| Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed By Surgery nab-paclitaxel - Intraocular Melanoma | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 4 | 2008-08-01 | 2016-02-12 |
| Vaccine Therapy in Treating Patients With Advanced Melanoma incomplete Freund's adjuvant, multi-epitope melanoma peptide vaccine, tetanus toxoid helper peptide - Intraocular Melanoma, Malignant Conjunctival Neoplasm | Phase 1 | Completed | Craig L Slingluff, Jr | 45 | 2008-05-01 | 2016-12-16 |
| Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom DNA analysis, polymorphism analysis, laboratory biomarker analysis - Bladder Cancer, Brain and Central Nervous System Tumors | Unknown | Cancer Research UK | 14000 | 2008-02-01 | 2013-08-26 | |
| Bone Marrow and Blood Samples From Patients With Metastatic Choroid Melanoma gene expression analysis, reverse transcriptase-polymerase chain reaction, laboratory biomarker analysis - Intraocular Melanoma | Completed | Institut Curie | 15 | 2007-11-01 | 2011-05-13 | |
| Sunitinib, Tamoxifen, and Cisplatin in Treating Patients With High-Risk Ocular Melanoma cisplatin, sunitinib malate, tamoxifen citrate - Intraocular Melanoma | Phase 2 | Unknown | San Diego Pacific Oncology & Hematology Associates | 50 | 2007-05-01 | 2014-01-10 |
| Lenalidomide, Sunitinib, and Cyclophosphamide in Treating Patients With Stage IV Eye Melanoma cyclophosphamide, lenalidomide, sunitinib malate - Intraocular Melanoma, Malignant Conjunctival Neoplasm | Phase 2 | Terminated | National Institutes of Health Clinical Center (CC) | 12 | 2007-04-01 | 2017-03-27 |
| Safety and Immunogenicity of a Melanoma DNA Vaccine Delivered by Electroporation Xenogeneic Tyrosinase DNA Vaccine, TriGrid Delivery System for Intramuscular Electroporation - Melanoma (Skin), Intraocular Melanoma | Phase 1 | Completed | Ichor Medical Systems Incorporated | 24 | 2007-04-01 | 2011-06-07 |
| Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma mouse gp100 plasmid DNA vaccine, The Dermal PowderMed® devices, intramuscularly (IM injection) - Intraocular Melanoma, Melanoma (Skin) | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 35 | 2006-10-01 | 2017-03-16 |
| Hepatic Arterial Infusion With Melphalan Compared With Standard Therapy in Treating Patients With Unresectable Liver Metastases Due to Melanoma melphalan, regional chemotherapy, systemic chemotherapy - Intraocular Melanoma, Melanoma (Skin) | Phase 3 | Completed | Delcath Systems Inc. | 93 | 2006-02-01 | 2021-06-21 |
| Dendritic Cell Vaccination During Lymphoid Reconstruction Autologous Dendritic Cells (DC), Fludarabine, Autologous Lymphocyte Infusion (ALI) - Intraocular Melanoma, Melanoma (Skin) | Phase 1 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 18 | 2006-02-01 | 2014-02-21 |
| Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer DNA analysis, immunologic technique, pharmacological study - Brain and Central Nervous System Tumors, Intraocular Melanoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 78 | 2006-01-01 | 2024-04-04 |
| AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma cediranib maleate - Acral Lentiginous Malignant Melanoma, Ciliary Body and Choroid Melanoma, Medium/Large Size | Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2006-01-01 | 2018-08-27 |
| Intravenous or Hepatic Arterial Infusion of Fotemustine in Treating Patients With Unresectable Liver Metastases From Eye Melanoma fotemustine, isolated perfusion - Intraocular Melanoma, Metastatic Cancer | Phase 3 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 171 | 2005-01-01 | 2012-09-24 |
| Monoclonal Antibody Therapy and Vaccine Therapy in Treating Patients With Resected Stage III or Stage IV Melanoma ipilimumab, Tyrosinase/gp100/MART-1 Peptides - Intraocular Melanoma, Melanoma (Skin) | Phase 2 | Completed | Bristol-Myers Squibb | 77 | 2004-05-31 | 2022-04-14 |
| Vaccine Therapy in Treating Patients With Metastatic Melanoma MART-1 antigen, gp100:209-217(210M) peptide vaccine, therapeutic autologous dendritic cells - Intraocular Melanoma, Melanoma (Skin) | Phase 2 | Completed | University of Southern California | 6 | 2003-10-01 | 2014-05-21 |
| Temozolomide, Thalidomide, and Lomustine in Treating Patients With Unresectable Stage III or Stage IV Melanoma lomustine, temozolomide, thalidomide - Intraocular Melanoma, Melanoma (Skin) | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 2003-07-01 | 2013-01-18 | |
| Vaccine Therapy in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Melanoma IFA, 6MHP, GM-CSF - Intraocular Melanoma, Melanoma (Skin) | Phase 1 / Phase 2 | Completed | University of Virginia | 39 | 2003-07-01 | 2014-11-20 |
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Uveal Melanoma (34) · Melanoma (26) · Central Nervous System Neoplasms (4) · Astrocytoma (3) · Brain Neoplasms (3) · Lung Neoplasms (3) · Neoplasm Metastasis (3) · Small Cell Lung Carcinoma (3) · Carcinoma, Renal Cell (2) · Ependymoma (2) · Familial ependymoma (2) · Glioblastoma (2) · Glioma (2) · Gliosarcoma (2) · Kidney Neoplasms (2)
Eye Diseases (34) · Eye Neoplasms (34) · Neoplasms by Histologic Type (34) · Neoplasms by Site (34) · Neoplasms, Nerve Tissue (34) · Neuroectodermal Tumors (34) · Neuroendocrine Tumors (34) · Nevi and Melanomas (34) · Uveal Diseases (34) · Uveal Neoplasms (34) · Neoplasms (33) · Neoplasms, Germ Cell and Embryonal (33) · Skin Diseases (26) · Skin Neoplasms (26) · Skin and Connective Tissue Diseases (26)
incomplete Freund's adjuvant (8) · MART-1 Antigen (5) · Ipilimumab (4) · Temozolomide (4) · sargramostim (4) · Chemotherapy, Adjuvant (3) · Thalidomide (3) · Amplified Fragment Length Polymorphism Analysis (2) · Granulocyte-Macrophage Colony-Stimulating Factor (2) · Interleukin-12 Subunit p35 (2) · Monophenol Monooxygenase (2) · Protein Subunit Vaccines (2) · Sunitinib (2) · 130-nm albumin-bound paclitaxel (1) · 4-amino-4'-hydroxylaminodiphenylsulfone (1)
Memorial Sloan Kettering Cancer Center (6) · University of Southern California (5) · National Cancer Institute (NCI) (3) · European Organisation for Research and Treatment of Cancer - EORTC (2) · Institut Curie (2) · University of Virginia (2) · Ahmad Tarhini (1) · Barbara Ann Karmanos Cancer Institute (1) · Bristol-Myers Squibb (1) · Cancer Research UK (1) · Case Comprehensive Cancer Center (1) · Craig L Slingluff, Jr (1) · Delcath Systems Inc. (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Ichor Medical Systems Incorporated (1)
United States (28) · United Kingdom (2) · Belgium (1) · Canada (1) · Denmark (1) · France (1) · Italy (1) · Poland (1) · Switzerland (1)
Jeffrey S. Weber, MD, PhD (5) · Craig L. Slingluff, MD (3) · Wen-Jen Hwu, MD, PhD (3) · Kim Kramer, MD (2) · Steven A. Rosenberg, MD, PhD (2) · Ahmad A. Tarhini, MD, MS (1) · Arun D. Singh, MD (1) · Edward F. McClay, MD (1) · Elaine McWhirter (1) · Jan U. Prause, MD (1) · Jedd D. Wolchok, MD (1) · Jedd D. Wolchok, MD, PhD (1) · Jeffrey S. Weber, M.D., Ph.D. (1) · John R. Murren, MD (1)
PMID 25667295, PMID 12039921, PMID 12684398, PMID 12826605, PMID 12947072, PMID 16087944, PMID 16283570, PMID 18048828, PMID 18809608, PMID 20727190, PMID 21106722, PMID 22027909, PMID 22495394, PMID 23197414, PMID 24510314, PMID 24829756, PMID 25126421, PMID 28851380, PMID 32161584, PMID 32350119
2004 (1), N01CM62201 (1), N01CM62203 (1), P30CA006973 (1), P30CA008748 (1), P30CA014089 (1), P30CA022453 (1), P30CA043703 (1), P30CA044579 (1), P30CA076292 (1), R01CA057653 (1), U01CA063437 (1)