3 completed, 1 recruiting. 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
Follow Immune Deficiency Disease: new trials by email Literature Review of Immune Deficiency Disease trials Research Report on Immune Deficiency Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| B-pVAC-SARS-CoV-2: Study to Prevent COVID-19 Infection in Adults With Bcell/ Antibody Deficiency CoVAC-1 - Immune Deficiency Disease | Phase 1 / Phase 2 | Completed | University Hospital Tuebingen | 54 | 2021-06-30 | 2023-08-04 |
| Regenerative Medicine to Restore Hematopoiesis and Immune Function in Immunodeficiencies and Inherited Bone Marrow Failures Alemtuzumab, Fludarabine, Melphalan - Primary Immune Deficiency Disorder, Immune Deficiency Disease | Phase 2 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 27 | 2020-02-12 | 2025-11-28 |
| Memory T-cell Infusion to Improve Immunity After TCR-alpha/Beta Depleted Hematopoietic Stem Cell Transplantation CD45RA-depleted peripheral blood mononuclear cells - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute | Phase 1 / Phase 2 | Completed | Federal Research Institute of Pediatric Hematology, Oncology and Immunology | 30 | 2014-08-01 | 2016-04-22 |
| Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency CD34+ cells transduced with ADA retrovir - Severe Combined Immunodeficiency Syndrome | Phase 1 | Completed | National Human Genome Research Institute (NHGRI) | 8 | 2001-06-20 | 2019-12-12 |
Bone Marrow Failure Disorders (2) · Dyskeratosis Congenita (1) · Fanconi Anemia (1) · Graft vs Host Disease (1) · Hoyeraal Hreidarsson syndrome (1) · Immunologic Deficiency Syndromes (1) · Leukemia, Myeloid, Acute (1) · Opportunistic Infections (1) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (1) · Primary Immunodeficiency Diseases (1) · Severe Combined Immunodeficiency (1) · Severe combined immunodeficiency due to adenosine deaminase deficiency (1)
Immune System Diseases (3) · Bone Marrow Diseases (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · DNA Repair-Deficiency Disorders (2) · Genetic Diseases, Inborn (2) · Hematologic Diseases (2) · Hemic and Lymphatic Diseases (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Anemia (1) · Anemia, Aplastic (1) · Anemia, Hypoplastic, Congenital (1) · Congenital Abnormalities (1) · Congenital Bone Marrow Failure Syndromes (1) · Genetic Diseases, X-Linked (1)
Alemtuzumab (1) · COVAC-1 COVID-19 vaccine (1) · Cyclophosphamide (1) · Melphalan (1) · Mycophenolic Acid (1) · Tacrolimus (1) · Whole-Body Irradiation (1) · fludarabine (1)
Federal Research Institute of Pediatric Hematology, Oncology and Immunology (1) · National Human Genome Research Institute (NHGRI) (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · University Hospital Tuebingen (1)
United States (2) · Germany (1) · Russia (1)
Heather J Symons, MD, MHS (1) · Helmut Salih, Prof. MD (1) · Michael Maschan, MD (1) · Robert A Sokolic, M.D. (1)