2 completed, 1 recruiting, 1 suspended, 1 terminated. 5 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 2, Recruiting 1, Suspended 1, Terminated 1 |
| Phase 2 | 4 | Completed 1, Recruiting 1, Suspended 1, Terminated 1 |
Follow Homocystinuria: new trials by email Literature Review of Homocystinuria trials Research Report on Homocystinuria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability and Pharmacodynamics of SYNB1353 in Healthy Adult Volunteers SYNB1353 - Homocystinuria | Phase 1 | Completed | Synlogic | 31 | 2022-07-07 | 2023-03-17 |
| Effect of Acetaminophen and N-Acetylcysteine on Liver Metabolism on Homocystinuria Acetaminophen, N-acetylcysteine - CBS Deficiency | Phase 1 / Phase 2 | Suspended | Hospital de Clinicas de Porto Alegre | 10 | 2022-02-11 | 2021-06-30 |
| A Multiple Ascending Dose Study of ACN00177 (Pegtarviliase) in Subjects With CBS Deficiency Pegtarviliase IV, Pegtarviliase SC - Homocystinuria Due to Cystathionine Beta-Synthase Deficiency | Phase 1 / Phase 2 | Terminated | Aeglea Biotherapeutics | 13 | 2021-05-13 | 2023-07-27 |
| Pegtibatinase as a Treatment for Patients With Classical Homocystinuria (HCU) (Also Known as the COMPOSE Study) Pegtibatinase, Placebo - Homocystinuria | Phase 1 / Phase 2 | Recruiting | Travere Therapeutics, Inc. | 39 | 2019-01-22 | 2026-08-10 |
| Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine taurine - Homocystinuria | Phase 1 / Phase 2 | Completed | University of Colorado, Denver | 15 | 2010-01-01 | 2018-07-09 |
Amino Acid Metabolism, Inborn Errors (5) · Brain Diseases (5) · Brain Diseases, Metabolic (5) · Brain Diseases, Metabolic, Inborn (5) · Central Nervous System Diseases (5) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Connective Tissue Diseases (5) · Genetic Diseases, Inborn (5) · Hyperhomocysteinemia (5) · Metabolic Diseases (5) · Nervous System Diseases (5) · Nutritional and Metabolic Diseases (5) · Skin and Connective Tissue Diseases (5) · Metabolism, Inborn Errors (4)
Acetaminophen (1) · Acetylcysteine (1) · Taurine (1)
Aeglea Biotherapeutics (1) · Hospital de Clinicas de Porto Alegre (1) · Synlogic (1) · Travere Therapeutics, Inc. (1) · University of Colorado, Denver (1)
United States (4) · Australia (1) · Brazil (1) · France (1) · Qatar (1) · United Kingdom (1)
Cortney Caudill (1) · Ida VD Schwartz, PhD (1) · Johan VanHove, MD PhD MBA (1) · Michael Imperiale, MD (1)
2019 (1)