7 completed, 3 terminated. 7 Phase 1, 3 Phase 2, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 5, Terminated 2 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of SYNB1934 in Patients With PKU (SYNPHENY-3) SYNB1934v1, Placebo - Phenylketonuria | Phase 3 | Terminated | Synlogic | 35 | 2023-07-05 | 2024-06-20 |
| Safety, Tolerability and Pharmacodynamics of SYNB1353 in Healthy Adult Volunteers SYNB1353 - Homocystinuria | Phase 1 | Completed | Synlogic | 31 | 2022-07-07 | 2023-03-17 |
| Safety, Tolerability, and Pharmacodynamics of SYNB8802v1 in Subjects With History of Gastric Bypass Surgery or Short-bowel Syndrome SYNB8802v1, Placebo - Enteric Hyperoxaluria | Early Phase 1 | Completed | Synlogic | 11 | 2022-03-29 | 2023-03-17 |
| Safety and Tolerability of SYNB1934 in Healthy Adult Volunteers SYNB1934, SYNB1618 - Healthy | Phase 1 | Completed | Synlogic | 106 | 2021-07-02 | 2022-05-18 |
| Safety and Tolerability of SYNB8802 in Healthy Adult Volunteers and Adult Subjects With Enteric Hyperoxaluria SYNB8802, Placebo - Healthy, Enteric Hyperoxaluria | Phase 1 | Completed | Synlogic | 77 | 2020-11-04 | 2024-03-08 |
| Efficacy and Safety of SYNB1618 and SYNB1934 in Adult Patients With Phenylketonuria SYNB1618, SYNB1934 - Phenylketonuria | Phase 2 | Completed | Synlogic | 20 | 2020-08-25 | 2022-10-17 |
| Safety and Tolerability of SYNB1891 Injection Alone or in Combination With Atezolizumab in Adult Participants SYNB1891, Atezolizumab - Metastatic Solid Neoplasm, Lymphoma | Phase 1 | Terminated | Synlogic | 32 | 2019-12-12 | 2024-05-03 |
| Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria SYNB1618, Placebo - Phenylketonuria, Healthy | Phase 1 / Phase 2 | Completed | Synlogic | 70 | 2018-04-17 | 2021-05-13 |
| Safety, Tolerability and Pharmacodynamics of SYNB1020 SYNB1020, Placebo - Cirrhosis | Phase 1 / Phase 2 | Terminated | Synlogic | 23 | 2018-03-19 | 2021-05-13 |
| Safety and Tolerability of SYNB1020-CP-001 Placebo, SYNB1020 - Healthy Volunteer, Urea Cycle Disorder | Phase 1 | Completed | Synlogic | 52 | 2017-06-16 | 2021-05-12 |
Phenylketonurias (3) · Metabolism, Inborn Errors (2) · Fibrosis (1) · Homocystinuria (1) · Lymphoma (1) · Neoplasm Metastasis (1) · Urea Cycle Disorders, Inborn (1)
atezolizumab (1)
United States (10) · Canada (1) · Georgia (1) · Turkey (Türkiye) (1)
Aoife Brennan, MB, BCh, BAO, MMSc (1)