12 completed. 12 Phase 2.
By phase and status
Follow HCV Infection: new trials by email Literature Review of HCV Infection trials Research Report on HCV Infection
Trials (filtered) newest first · largest first
All 12 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
Study of AT-527 in Combination With Daclatasvir in Subjects With Hepatitis C Virus (HCV) Infection AT-527, Daclatasvir - Hepatitis C, Hepatitis C, Chronic | Phase 2 | Completed | 10 | 2019-06-20 | 2020-05-04 |
Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079) EBR/GZR FDC Tablet, Placebo, Grazoprevir Oral Granules - HCV Infection | Phase 2 | Completed | 57 | 2018-01-25 | 2023-05-31 |
Ledipasvir/Sofosbuvir Fixed-Dose Combination ± Ribavirin in Participants With Chronic Genotype 1 HCV Who Participated in a Prior Gilead-Sponsored HCV Treatment Study LDV/SOF, RBV - HCV Infection | Phase 2 | Completed | 100 | 2014-07-01 | 2018-11-19 |
Sofosbuvir Plus Ribavirin, or Ledipasvir/Sofosbuvir in Adults With HCV Infection and Renal Insufficiency SOF, RBV, LDV/SOF - HCV Infection | Phase 2 | Completed | 38 | 2013-10-07 | 2018-08-08 |
Efficacy and Safety of Sofosbuvir/Ledipasvir Fixed-Dose Combination ± Ribavirin in Cirrhotic Subjects With Chronic Genotype 1 HCV Infection LDV/SOF, RBV, Placebo to match LDV/SOF - HCV Infection | Phase 2 | Completed | 155 | 2013-10-01 | 2018-11-16 |
Efficacy of PegInterferon-Ribavirin-Boceprevir Therapy in Patients Infected With G1 HCV With Cirrhosis, Awaiting Liver Transplantation Boceprevir, Peg-Interferon α-2b or Peg-Interferon α-2a, Ribavirin - HCV Infection, Liver Cirrhosis, Experimental | Phase 2 | Completed | 58 | 2012-01-06 | 2026-04-07 |
Efficacy and Safety Study of GS-9256 and GS-9190 Alone and in Combination With Ribavirin for 28 Days in Patients With Chronic Hepatitis C Virus Infection GS-9256, GS-9190, Ribavirin - HCV Infection | Phase 2 | Completed | 46 | 2010-02-01 | 2012-05-31 |
A Phase 2b, Safety and Efficacy Study of Boceprevir in Patients Coinfected With HIV and Hepatitis C (P05411 AM4) PegIFN-2b, RBV, Placebo to Boceprevir - HIV Infections, Hepatitis C | Phase 2 | Completed | 99 | 2009-11-01 | 2017-04-07 |
Safety, Tolerability, and Antiviral Activity of ANA598 Administered in Combination With Pegylated Interferon and Ribavirin for the Treatment of Genotype-1 Chronic HCV Infection placebo, ANA598, Peginterferon - HCV Infection | Phase 2 | Completed | 97 | 2009-09-01 | 2017-03-31 |
Safety, Tolerability, and Antiviral Activity of 24 or 48 Weeks of GS-9190 in Combination With Peginterferon Alfa 2a and Ribavirin for the Treatment of Genotype-1 Chronic HCV Infection placebo, GS-9190, Peginterferon Alfa 2a - HCV Infection | Phase 2 | Completed | 252 | 2008-10-01 | 2013-11-05 |
A Follow-up Assessment of Resistance to ABT-333 in Hepatitis C Virus (HCV)-Infected Subjects Who Have Received ABT-333 in ABT-333 Studies Blood sample collection only, ABT-333 - HCV Infection | Phase 2 | Completed | 35 | 2008-08-01 | 2015-01-08 |
Evaluation of the Safety, Tolerability, Pharmacokinetics, and Activity of GS-9450 in Subjects With Chronic HCV GS-9450, GS-9450 Placebo - HCV Infection | Phase 2 | Completed | 33 | 2008-04-01 | 2014-06-19 |
Narrower conditions
Hepatitis C (12) · Fibrosis (2) · Coinfection (1) · HIV Infections (1) · Hepatitis C, Chronic (1) · Liver Cirrhosis, Experimental (1)
Broader conditions
Blood-Borne Infections (12) · Communicable Diseases (12) · Digestive System Diseases (12) · Flaviviridae Infections (12) · Hepatitis (12) · Hepatitis, Viral, Human (12) · Infections (12) · Liver Diseases (12) · RNA Virus Infections (12) · Virus Diseases (12) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Chronic Disease (1) · Disease Attributes (1) · Fibrosis (1)
Interventions
Ribavirin (5) · ledipasvir, sofosbuvir drug combination (3) · N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide (2) · peginterferon alfa-2a (2) · peginterferon alfa-2b (2) · tegobuvir (2) · AT-511 (1) · GS-9256 (1) · Sofosbuvir (1) · daclatasvir (1) · dasabuvir (1) · elbasvir (1) · elbasvir-grazoprevir drug combination (1) · grazoprevir (1) · setrobuvir (1)
Sponsors
Gilead Sciences (6) · Merck Sharp & Dohme LLC (2) · AbbVie (prior sponsor, Abbott) (1) · Atea Pharmaceuticals, Inc. (1) · French National Agency for Research on AIDS and Viral Hepatitis (1) · Hoffmann-La Roche (1)
Countries
United States (7) · Puerto Rico (5) · France (4) · Germany (4) · Belgium (3) · Poland (2) · United Kingdom (2) · Australia (1) · Ireland (1) · Mauritius (1) · Moldova (1) · Netherlands (1) · New Zealand (1) · Spain (1) · Sweden (1)
Top investigators
Daniel E Cohen, MD (1) · David Oldach, MD (1) · Didier Samuel, Pr (1) · Juan Betular (1) · Robert H Hyland, DPhil (1) · Steven Knox (1) · Xiao-Jian Zhou, PhD (1)
Results publications
PMID 23768747, PMID 25773757, PMID 25846014, PMID 27554134, PMID 32531259, PMID 36790337
NIH funding
2014 (1), 2015 (1), 2019 (1)