2 not yet recruiting, 1 enrolling by invitation, 1 recruiting. 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Not yet recruiting 2, Enrolling by invitation 1, Recruiting 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
Follow Diffuse Midline Glioma (DMG): new trials by email Literature Review of Diffuse Midline Glioma (DMG) trials Research Report on Diffuse Midline Glioma (DMG)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG) FZ-AD005 - High Grade Glioma (III or IV), Diffuse Midline Glioma (DMG) | Phase 1 | Not yet recruiting | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | 40 | 2026-03-01 | 2026-03-06 |
| Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade Glioma Nivolumab, Azacitidine (AZA), lumbar puncture - Glioblastoma (GBM), Diffuse Midline Glioma (DMG) | Phase 1 | Enrolling by invitation | Andrew P. Groves | 34 | 2025-06-05 | 2026-10-27 |
| ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS) - Diffuse Midline Glioma (DMG), Glioblastoma | Phase 1 | Recruiting | Sabine Mueller, MD, PhD | 208 | 2021-08-23 | 2026-06-11 |
Glioblastoma (3) · Astrocytoma (1) · Central Nervous System Neoplasms (1) · Diffuse Intrinsic Pontine Glioma (1) · Ependymoma (1) · Glioma (1)
Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neoplasms, Neuroepithelial (4) · Neuroectodermal Tumors (4) · Glioma (3) · Astrocytoma (2) · Neoplasms by Site (2) · Nervous System Diseases (2) · Nervous System Neoplasms (2) · Brain Diseases (1) · Brain Neoplasms (1) · Brain Stem Neoplasms (1)
Azacitidine (1) · Magnetic Resonance Spectroscopy (1) · Nivolumab (1) · ONC206 (1) · Radiation (1) · Radiotherapy (1) · Spinal Puncture (1)
Andrew P. Groves (1) · NanOlogy, LLC (1) · Sabine Mueller, MD, PhD (1) · Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. (1)
United States (2) · China (1) · Netherlands (1) · Switzerland (1)
R01CA266596 (1)