9 completed, 5 recruiting, 3 terminated, 3 unknown. 7 Not applicable, 6 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Recruiting 3, Completed 2, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 6 | Completed 3, Unknown 2, Terminated 1 |
| Phase 1 | 3 | Terminated 2, Completed 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Chronic Leukemia: new trials by email Literature Review of Chronic Leukemia trials Research Report on Chronic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Feasibility Study to Evaluate a Digital Tool for Monitoring Patients Who Have Discontinued Treatment for Chronic Myeloid Leukemia Integration of a digital tool - Chronic Leukemia | Not applicable | Not yet recruiting | Versailles Hospital | 20 | 2026-09-15 | 2026-08-12 |
| Feasibility of a Multi-omics Platform for Hematological Malignancies Multi-omics analyses, Functional tests - Myeloma Multiple, Chronic Leukemia | Not applicable | Recruiting | Azienda Ospedaliero-Universitaria di Parma | 1040 | 2025-03-31 | 2026-03-03 |
| INTEGRATIVE "MULTI-OMICS" AND FUNCTIONAL PLATFORM FOR THE COMPLETE DIAGNOSTIC CHARACTERIZATION OF TUMORS: THE ITALIAN TUMOR CHEMOGENOMIC PROFILER (IT-TCP) Functional tests, Multi-omics analyses, Cytogenetics/ FISH - Acute Leukemia, Multiple Myeloma | Not applicable | Recruiting | Azienda Ospedaliero-Universitaria di Parma | 300 | 2023-05-31 | 2026-02-17 |
| Evaluation of a Pain Management Intervention Preparatory to a Future Pragmatic Trial, ASCENT Study Acupuncture Therapy, Cancer Pain Management, Cognitive Behavior Therapy - Chronic Leukemia, Hematopoietic and Lymphoid System Neoplasm | Not applicable | Completed | Mayo Clinic | 51 | 2023-05-22 | 2025-09-18 |
| LIVInG With chrONic Cancer TrEatments (LONGEVITI) Study Cancer, Tyrosine Kinase Mutation | Recruiting | University of Alberta | 75 | 2022-11-24 | 2026-05-11 | |
| Chemogenomic Profiling in Hematological Malignancies (HEM-Profiling 2021) Genetic, molecular and/or omics analyses - Chronic Leukemia, Acute Leukemia | Not applicable | Recruiting | Azienda Ospedaliero-Universitaria di Parma | 250 | 2021-07-28 | 2026-03-03 |
| Is There an Association Between Innate CD8+ T Cells and the Evolution of Tyrosine Kinase Inhibitor Resistance Mutations in Phi+ Hematological Malignancies. Phenotyping of total and innate CD8+T cells by flow cytometry - Leukemia, Myelogenous Leukemia | Completed | Centre Hospitalier Universitaire de Nīmes | 30 | 2021-01-01 | 2026-06-16 | |
| Nivolumab and Tocilizumab for Relapsed Hematological Malignancy Post-allogeneic Transplant Nivolumab (.25 mg/kg), Tocilizumab, Nivolumab (.5 mg/kg) - Acute Leukemia, Chronic Leukemia | Phase 1 | Terminated | Medical College of Wisconsin | 2 | 2018-09-14 | 2021-10-11 |
| Study of Predictive Immunological Parameters of Molecular Complete Remission in Patients With Chronic Myelogenous Leukemia in Chronic Phase and Treated With Tyrosine Kinase Inhibitor Additional biological samples - Chronic Leukemia | Not applicable | Completed | Centre Hospitalier Universitaire de Besancon | 57 | 2016-05-01 | 2025-05-25 |
| Umbilical Cord Blood Transplantation From Unrelated Donors Total Body Irradiation 1200 cGy, Total Body Irradiation 200 cGy, Cyclophosphamide - Acute Leukemia, Immune Deficiency Disorder | Recruiting | University of Rochester | 30 | 2015-06-01 | 2025-10-10 | |
| Nonmyeloablative Haploidentical Transplant Followed by MLN9708 MLN9708 - Acute Leukemia, Chronic Leukemia | Phase 2 | Completed | Northside Hospital, Inc. | 29 | 2014-07-15 | 2021-09-02 |
| Biparental HLA Haplotype Disparate T-cell Depleted Transplants for Patients Lacking an HLACompatible Donor total-body irradiation (TBI), thiotepa, fludarabine phosphate - Acute Leukemia, Chronic Leukemia | Not applicable | Terminated | Memorial Sloan Kettering Cancer Center | 3 | 2012-05-02 | 2018-08-09 |
| Clinical Ex Vivo Expansion of Human Umbilical Cord Blood Stem and Progenitor Cells Ex vivo expanded cord blood cells - Acute Leukemia, Chronic Leukemia | Phase 1 / Phase 2 | Terminated | Singapore General Hospital | 3 | 2012-03-01 | 2015-11-30 |
| Pharmacokinetic Study of Fludarabine in Pediatric Hematopoietic Stem Cell Transplantation Fludarabine - Acute Leukemia, Chronic Leukemia | Phase 2 | Unknown | Seoul National University Hospital | 46 | 2011-10-01 | 2014-08-20 |
| Total Body Irradiation/Fludarabine Based Ablative Haploidentical Transplant for Hematologic Diseases Peripheral Blood Stem Cell Transplant - Chronic Leukemia, Acute Leukemia | Phase 2 | Completed | Northside Hospital, Inc. | 30 | 2011-04-01 | 2016-01-14 |
| Fungemia in Hematologic Malignancies Acute Leukemia, Chronic Leukemia | Completed | Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne | 300 | 2011-01-01 | 2016-10-20 | |
| Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Analyze the pharmacokinetics of busulfan for transplantation - Acute Leukemia, Chronic Leukemia | Phase 2 / Phase 3 | Unknown | Hospital Israelita Albert Einstein | 100 | 2010-03-01 | 2014-12-03 |
| Analysis of Data Collected in the European Group for Blood and Marrow Transplantation (EBMT) Registry for Off-Label Transplant Use of Plerixafor Acute Leukemia, Chronic Leukemia | Completed | Genzyme, a Sanofi Company | 201 | 2009-07-01 | 2015-08-13 | |
| Trial of AVN-944 in Patients With Advanced Hematologic Malignancies AVN-944 capsules for oral administration - Acute Leukemia, Chronic Leukemia | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 72 | 2006-01-01 | 2011-08-04 |
| Phase 2 Fludarabine, Cytoxan and FCCAM <Alemtuzumab> in Untreated B-Cell Chronic Lymphocytic Leukemia Alemtuzumab, Fludarabine, Cytoxan - Leukemia, B-cell Leukemia | Phase 2 | Completed | Steven E. Coutre | 25 | 2004-07-01 | 2014-10-06 |
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Multiple Myeloma (8) · Lymphoma (7) · Myelodysplastic Syndromes (7) · Myeloproliferative Disorders (5) · Lymphoma, Non-Hodgkin (3) · Lymphoproliferative Disorders (3) · Anemia, Aplastic (2) · Hematologic Neoplasms (2) · Hodgkin Disease (2) · Immunologic Deficiency Syndromes (2) · Leukemia (2) · Melanoma (2) · Ovarian Neoplasms (2) · Anemia, Refractory, with Excess of Blasts (1) · Breast Neoplasms (1)
Hematologic Diseases (19) · Hemic and Lymphatic Diseases (19) · Immune System Diseases (16) · Immunoproliferative Disorders (16) · Lymphatic Diseases (15) · Neoplasms by Histologic Type (15) · Neoplasms (14) · Bone Marrow Diseases (13) · Lymphoproliferative Disorders (13) · Hemorrhagic Disorders (9) · Blood Protein Disorders (8) · Cardiovascular Diseases (8) · Hemostatic Disorders (8) · Neoplasms, Plasma Cell (8) · Paraproteinemias (8)
Cyclophosphamide (3) · fludarabine (3) · fludarabine phosphate (3) · Busulfan (2) · Melphalan (2) · Peripheral Blood Stem Cell Transplantation (2) · AVN 944 (1) · Acupuncture Therapy (1) · Alemtuzumab (1) · Analgesia (1) · Antilymphocyte Serum (1) · Cognitive Behavioral Therapy (1) · Early Intervention, Educational (1) · Educational Status (1) · Exercise (1)
Azienda Ospedaliero-Universitaria di Parma (3) · Northside Hospital, Inc. (2) · Alliance for Clinical Trials in Oncology (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier Universitaire de Nīmes (1) · Genzyme, a Sanofi Company (1) · Hospital Israelita Albert Einstein (1) · Mayo Clinic (1) · Medical College of Wisconsin (1) · Memorial Sloan Kettering Cancer Center (1) · Seoul National University Hospital (1) · Singapore General Hospital (1) · Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne (1) · Steven E. Coutre (1) · University of Alberta (1)
United States (9) · Italy (4) · France (3) · Brazil (1) · Canada (1) · Singapore (1) · South Korea (1)
Andrea L. Cheville, M.D. (1) · Hyoung Jin Kang, MD., PhD (1) · Livio Pagano, Professor (1) · Michael Caligiuri, MD (1) · Nelson Hamerschlak, Doctor (1) · Nirav Shah, MD (1) · Omar Aljitawi, MD (1) · Richard O'Reilly, MD (1) · Scott R Solomon, MD (1) · Steven Edward Coutre (1) · William YK Hwang, MBBS, FRCP (1)
PMID 16423993, PMID 31089278, PMID 31375516, PMID 32777064, PMID 34847232, PMID 36823396, PMID 37196637, PMID 38017103, PMID 38702786, PMID 39283025
U10CA031946 (1)