4 recruiting, 2 not yet recruiting, 2 withdrawn, 1 active not recruiting. 9 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Recruiting 4, Not yet recruiting 2, Withdrawn 2, Active not recruiting 1 |
| Phase 2 | 1 | Withdrawn 1 |
Follow CAR-T Cell Therapy: new trials by email Literature Review of CAR-T Cell Therapy trials Research Report on CAR-T Cell Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metabolically Fit CD19 CAR T Cells With CD34 Selection Markers in Adults With CD19-Positive B-Cell Acute Lymphocytic Leukemia Fludarabine, Cyclophosphamide, Levetiracetam - CD19 Positive, B-ALL | Phase 1 | Not yet recruiting | Medical University of South Carolina | 18 | 2026-11-01 | 2026-10-26 |
| Pre-emptive Anakinra for Cytokine Event Reduction Anakinra (Kineret®) - B-Acute Lymphoblastic Leukemia, CAR-T Cell Therapy | Phase 1 / Phase 2 | Withdrawn | Kevin McNerney | 2026-10-01 | 2026-08-13 | |
| A Study of A-CAR028 Treatment in Subjects With Relapsed or Refractory Acute Myeloid Leukemia A-CAR028 - Acute Myeloid Leukemia (AML), CAR-T Cell Therapy | Phase 1 | Recruiting | First Affiliated Hospital of Zhejiang University | 20 | 2025-09-30 | 2025-09-30 |
| Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cell Therapy in Patients With MDR-SRNS anti-CD19 CAR-T cells - Multi-Drug Resistant Nephrotic Syndrome, CAR-T Cell Therapy | Phase 1 | Withdrawn | The Children's Hospital of Zhejiang University School of Medicine | 2025-05-14 | 2026-06-16 | |
| CAR-T Technology for Recurrent/Refractory Malignant Hematological and Lymphatic Tumors CAR-T Therapy - CAR-T Cell Therapy, Lymphomas | Phase 1 | Not yet recruiting | Mingzhi Zhang | 30 | 2024-12-01 | 2024-10-17 |
| Study of Therapeutic Efficacy of CAR-T Cell Therapy in Patients With MDR-SRNS anti-BCMA/CD70 CAR-T cells - Multi-Drug Resistant Nephrotic Syndrome, CAR-T Cell Therapy | Phase 1 | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 18 | 2024-08-13 | 2025-08-29 |
| GPC3/Mesothelin-CAR-γδT Cells Against Cancers Cell therapy for solid tumors - Pancreas Cancer, Lung Cancer | Phase 1 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 30 | 2024-05-10 | 2024-06-26 |
| Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cells in Refractory Systemic Lupus Erythematosus anti-CD19-CAR-T cells - Systemic Lupus Erythematosus, CAR-T Cell Therapy | Phase 1 | Active not recruiting | The Children's Hospital of Zhejiang University School of Medicine | 22 | 2024-02-10 | 2026-02-04 |
| Mesothelin/GPC3/GUCY2C-CAR-T Cells Against Cancers CAR-T cells - Pancreas Cancer, CAR-T Cell Therapy | Phase 1 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 30 | 2023-03-10 | 2024-06-25 |
Burkitt Lymphoma (2) · Nephrotic Syndrome (2) · Pancreatic Neoplasms (2) · Cytokine Release Syndrome (1) · Leukemia, Myeloid, Acute (1) · Liver Neoplasms (1) · Lung Neoplasms (1) · Lupus Erythematosus, Systemic (1) · Lymphoma (1) · Mesothelioma (1) · Recurrence (1)
Neoplasms (6) · Neoplasms by Histologic Type (5) · Hemic and Lymphatic Diseases (4) · Immune System Diseases (4) · Immunoproliferative Disorders (3) · Lymphatic Diseases (3) · Lymphoproliferative Disorders (3) · DNA Virus Infections (2) · Digestive System Diseases (2) · Digestive System Neoplasms (2) · Endocrine Gland Neoplasms (2) · Endocrine System Diseases (2) · Epstein-Barr Virus Infections (2) · Female Urogenital Diseases (2) · Female Urogenital Diseases and Pregnancy Complications (2)
Immunotherapy, Adoptive (2) · Cell- and Tissue-Based Therapy (1) · Cyclophosphamide (1) · Interleukin 1 Receptor Antagonist Protein (1) · Levetiracetam (1) · fludarabine (1)
The Children's Hospital of Zhejiang University School of Medicine (3) · Second Affiliated Hospital of Guangzhou Medical University (2) · First Affiliated Hospital of Zhejiang University (1) · Kevin McNerney (1) · Medical University of South Carolina (1) · Mingzhi Zhang (1)
China (6) · United States (2)
Zhenfeng Zhang, MD, PhD (2) · Baratam Praneeth, MD (1) · Jianhua Mao, MD (1) · Jianhua Mao, PhD (1)
PMID 28925994, PMID 30592986, PMID 30842314, PMID 31974366, PMID 32472023, PMID 34347960, PMID 36109639
K12TR005104 (1)