13 completed, 5 unknown, 2 terminated, 2 withdrawn. 15 Phase 1, 14 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 9, Unknown 4, Terminated 1, Withdrawn 1 |
| Phase 2 | 14 | Completed 8, Unknown 3, Withdrawn 2, Terminated 1 |
| Not applicable | 1 | Unknown 1 |
Follow B-cell Adult Acute Lymphoblastic Leukemia: new trials by email Literature Review of B-cell Adult Acute Lymphoblastic Leukemia trials Research Report on B-cell Adult Acute Lymphoblastic Leukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Blinatumomab for MRD in Pre-B ALL Patients Following Stem Cell Transplant blinatumomab - B-cell Adult Acute Lymphoblastic Leukemia, Stem Cell Leukemia | Phase 2 | Terminated | University of British Columbia | 8 | 2020-09-08 | 2022-02-21 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22 anti-CD19/22-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | Chinese PLA General Hospital | 30 | 2017-08-01 | 2019-04-17 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20 anti-CD19/20-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Chinese PLA General Hospital | 100 | 2017-04-01 | 2020-09-02 |
| Anti-CD19 CAR T Infusion Combined With Allogeneic Stem Cell Transplantation for B-cell Leukemia/Lymphoma anti-CD19 CAR-T, Fludarabine, Cyclophosphamide - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Unknown | First Affiliated Hospital of Wenzhou Medical University | 20 | 2016-10-01 | 2019-11-27 |
| Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma rituximab, lenalidomide, romidepsin - B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 1 / Phase 2 | Withdrawn | Mayo Clinic | 2016-10-01 | 2016-08-11 | |
| Competitive Transfer of αCD19-TCRz-CD28 and αCD19-TCRz-CD137 CAR-T Cells for B-cell Leukemia/Lymphoma anti-CD19 CAR-T, Fludarabine, Cyclophosphamide - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine | 20 | 2016-02-01 | 2017-03-16 |
| Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults MLN 9708, Vincristine, Cytarabine - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 1 | Completed | Massachusetts General Hospital | 19 | 2014-12-01 | 2019-11-26 |
| CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma 6,8-bis(benzylthio)octanoic acid, bendamustine hydrochloride, rituximab - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Terminated | Wake Forest University Health Sciences | 1 | 2014-12-01 | 2018-07-02 |
| S1312, Inotuzumab Ozogamicin and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Leukemia cyclophosphamide, vincristine sulfate, prednisone - Acute Leukemias of Ambiguous Lineage, B-cell Adult Acute Lymphoblastic Leukemia | Phase 1 | Completed | SWOG Cancer Research Network | 50 | 2014-06-13 | 2023-05-03 |
| Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by CART19 anti-CD19-CAR vector-transduced T cells - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Unknown | Chinese PLA General Hospital | 12 | 2013-04-01 | 2016-01-28 |
| Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy anti-CD20-CAR vector-transduced autologous T cells, genetically engineered lymphocyte therapy - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Unknown | Chinese PLA General Hospital | 50 | 2013-01-01 | 2015-09-29 |
| Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemia nilotinib, rituximab, cyclophosphamide - B-cell Adult Acute Lymphoblastic Leukemia, Blastic Phase Chronic Myelogenous Leukemia | Phase 2 | Withdrawn | Mayo Clinic | 2012-12-01 | 2015-10-30 | |
| Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | City of Hope Medical Center | 36 | 2012-10-29 | 2024-04-02 |
| Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma Akt inhibitor MK2206, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2010-12-01 | 2020-11-04 |
| CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy CART-19 - Hematopoietic/Lymphoid Cancer, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 | Completed | University of Pennsylvania | 26 | 2010-03-17 | 2023-06-22 |
| Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma panobinostat, everolimus, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 / Phase 2 | Completed | Mayo Clinic | 124 | 2009-06-01 | 2020-03-10 |
| Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 148 | 2009-03-01 | 2017-01-27 |
| Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma rituximab, peripheral blood stem cell transplantation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 63 | 2009-02-01 | 2018-01-02 |
| Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies double-unit umbilical cord blood transplantation, cytogenetic analysis, bone marrow aspiration - Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Case Comprehensive Cancer Center | 14 | 2007-09-01 | 2019-01-23 |
| Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia allopurinol, cyclophosphamide, daunorubicin hydrochloride - Acute Undifferentiated Leukemia, B-cell Adult Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 302 | 2003-06-01 | 2022-05-03 |
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Leukemia, Lymphocytic, Chronic, B-Cell (15) · Lymphoma, Follicular (14) · Lymphoma, Large B-Cell, Diffuse (14) · Lymphoma, Mantle-Cell (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (14) · Burkitt Lymphoma (8) · Lymphoma, B-Cell, Marginal Zone (8) · Hematologic Neoplasms (7) · Leukemia, Prolymphocytic (7) · Waldenstrom Macroglobulinemia (7) · Lymphoma, Large-Cell, Immunoblastic (6) · Lymphoma, Non-Hodgkin (6) · Leukemia, Hairy Cell (5) · Mycosis Fungoides (5) · Sezary Syndrome (5)
Hematologic Diseases (22) · Hemic and Lymphatic Diseases (22) · Leukemia (22) · Neoplasms (22) · Neoplasms by Histologic Type (22) · Immune System Diseases (21) · Immunoproliferative Disorders (21) · Leukemia, Lymphoid (21) · Lymphatic Diseases (21) · Lymphoproliferative Disorders (21) · Pathologic Processes (18) · Pathological Conditions, Signs and Symptoms (18) · Chronic Disease (17) · Disease Attributes (17) · Leukemia, B-Cell (15)
Cyclophosphamide (8) · Rituximab (5) · Vincristine (5) · Cytarabine (4) · Methotrexate (4) · Doxorubicin (3) · Leucovorin (3) · Prednisone (3) · merphos (3) · Asparaginase (2) · Cytogenetic Analysis (2) · Dexamethasone (2) · Filgrastim (2) · Flow Cytometry (2) · Interleukin-2 (2)
Chinese PLA General Hospital (4) · National Cancer Institute (NCI) (4) · Mayo Clinic (3) · Fred Hutchinson Cancer Center (2) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · First Affiliated Hospital of Wenzhou Medical University (1) · Massachusetts General Hospital (1) · SWOG Cancer Research Network (1) · The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine (1) · University of British Columbia (1) · University of Pennsylvania (1) · Wake Forest University Health Sciences (1)
United States (14) · China (6) · Canada (2) · Australia (1) · Puerto Rico (1)
Anjali Advani (1) · Aref Al-Kali, M.D. (1) · Brenda Cooper, MD (1) · David Maloney (1) · David Sanford, MD (1) · Grzegorz Nowakowski (1) · Kang Yu, M.D. (1) · Merav Bar (1) · Noelle Frey, MD (1) · Philip Amrein, MD (1) · Pierluigi Porcu (1) · Ryotaro Nakamura (1) · Shaji Kumar (1) · Terzah Horton, MD PhD (1) · Wendy Stock (1)
PMID 34515338, PMID 25317870, PMID 25444722, PMID 26213141, PMID 26451310, PMID 26853648, PMID 28419486, PMID 29263894, PMID 29599530, PMID 30562587, PMID 30957229, PMID 31076448, PMID 31481800, PMID 31815579, PMID 32245502, PMID 34935483, PMID 41804087
P30CA015083 (2), N01CM00039 (1), N01CM62202 (1), P01CA018029 (1), P01CA078902 (1), P30CA012197 (1), P30CA015704 (1), P30CA016672 (1), U01CA076576 (1), U10CA031946 (1), U10CA032102 (1), U10CA098543 (1), U10CA180886 (1), U10CA180888 (1)