234 recruiting, 175 completed, 141 unknown, 100 terminated. 695 Phase 1, 249 Phase 2, 14 Early Phase 1, 12 Not applicable, 4 Phase 3.
Follow Advanced Solid Tumor: new trials by email Literature Review of Advanced Solid Tumor trials Research Report on Advanced Solid Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Novel mRNA-LNP-Based Intratumoral Immunotherapy in Patients With Advanced Malignant Solid Tumors mRNA-LNP - Advanced Solid Tumor | Phase 1 / Phase 2 | Not yet recruiting | IntraAb, Inc. | 60 | 2027-01-01 | 2026-05-14 |
| Study of ISM5939 in Patients With Advanced and/or Metastatic Solid Tumors ISM5939, Cisplatin, Docetaxel - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Not yet recruiting | InSilico Medicine Hong Kong Limited | 159 | 2026-12-30 | 2026-07-23 |
| Study of PM54 in Combination With Cytotoxic and Targeted Agents in Adult Participants With Advanced Malignancies PM54, Irinotecan, Doxorubicin - Advanced Solid Tumor | Phase 1 / Phase 2 | Not yet recruiting | PharmaMar | 231 | 2026-11-12 | 2026-09-24 |
| Phase I Study of In Vivo CAR-Tumor Technology for the Treatment of Advanced Malignant Tumors CAR-Tumor05, CAR-Tumor 05, CAR-Tumor M01 - Advanced Solid Tumor | Phase 1 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 27 | 2026-11-01 | 2026-10-05 |
| Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function Larotinib - Esophageal Cancer, Advanced Solid Tumor | Phase 1 | Withdrawn | Sunshine Lake Pharma Co., Ltd. | 2026-10-30 | 2026-09-28 | |
| A First-in-Human Study Investigating BG-85738 Alone or in Combination With Other Antitumor Agents in Patients With Advanced or Metastatic Solid Tumors With Rat Sarcoma Virus (RAS) Mutations BG-85738, Tislelizumab, Cetuximab - RAS Mutation, Advanced Solid Tumor | Phase 1 | Recruiting | BeOne Medicines | 100 | 2026-09-02 | 2026-09-11 |
| A Phase I/IIa Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics, Immunogenicity, and Preliminary Efficacy of SGT003 in Patients With Advanced Solid Tumors SGT003 - Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Beijing Sungen Biomedical Technology Co., Ltd | 332 | 2026-08-17 | 2026-09-09 |
| Safety, Pharmacokinetics (PK), and Efficacy of ONC-783 in Advanced Solid Tumors ONC-783 - Advanced Solid Tumor | Phase 1 | Recruiting | OncoC4, Inc. | 20 | 2026-08-10 | 2026-09-08 |
| First-in-Human Trial of DS1025a in Participants With Advanced Solid Tumors DS1025a - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Recruiting | Daiichi Sankyo | 45 | 2026-08-06 | 2026-08-25 |
| XTX501 in Patients With Metastatic Non-Small Cell Lung Cancer and Advanced Solid Tumors XTX501 - Metastatic NSCLC - Non-Small Cell Lung Cancer, Advanced Solid Tumor | Phase 1 / Phase 2 | Not yet recruiting | Xilio Development, Inc. | 140 | 2026-08-01 | 2026-07-07 |
| A Study of LM-168 Combined With Other Anti-tumor Treatments in Participants With Advanced Solid Tumors LM-168, Tislelizumab, Docetaxel injection - Advanced Solid Tumor | Phase 2 | Recruiting | LaNova Medicines Limited | 108 | 2026-07-29 | 2026-07-30 |
| A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors ARV-6723, Pembrolizumab, SOC - Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Arvinas Inc. | 499 | 2026-07-29 | 2026-10-13 |
| Gotistobart Long Term Extension (LTE) Study Gotistobart - Advanced Solid Tumor | Phase 3 | Enrolling by invitation | OncoC4, Inc. | 20 | 2026-07-28 | 2026-08-24 |
| Study of D3L-002 in Subjects With Advanced Solid Tumors D3L-002 - Advanced Solid Tumor | Phase 1 | Recruiting | D3 Bio (Wuxi) Co., Ltd | 24 | 2026-07-14 | 2026-09-18 |
| A Study of IDP-001 in Advanced or Metastatic Solid Tumors IDP-001 - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 / Phase 2 | Recruiting | InduPro, Inc. | 132 | 2026-07-08 | 2026-09-03 |
| Evaluation of ICP-B208 in Patients With Advanced Solid Tumors ICP-B208 - Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Beijing InnoCare Pharma Tech Co., Ltd. | 539 | 2026-07-03 | 2026-07-10 |
| A Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101) CLSP-5282 - Advanced Solid Tumor, Non Small Cell Lung Cancer | Phase 1 | Not yet recruiting | Clasp Therapeutics, Inc. | 140 | 2026-07-01 | 2026-06-16 |
| Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab STX-003, KEYTRUDA® - Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Strand Therapeutics Inc. | 220 | 2026-06-30 | 2026-10-02 |
| A Clinical Study of ZL-85FA Tablets ZL-85FA tablets - Advanced Solid Tumor | Phase 1 / Phase 2 | Not yet recruiting | Chengdu Zenitar Biomedical Technology Co., Ltd | 51 | 2026-06-30 | 2026-01-15 |
| IPG7236 Combined With Toripalimab in Participants With Advanced Solid Tumors IPG7236, Toripalimab Injection - Advanced Solid Tumor | Phase 1 / Phase 2 | Recruiting | Nanjing Immunophage Biotech Co., Ltd | 52 | 2026-06-16 | 2026-06-29 |
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PMID 37788341, PMID 39097413, PMID 40082695, PMID 41087606, PMID 41423415, PMID 15016963, PMID 18616528, PMID 18794884, PMID 20626398, PMID 2161448, PMID 21964801, PMID 24099585, PMID 24450857, PMID 24450858, PMID 24615776, PMID 24615777, PMID 24668327, PMID 26096650, PMID 26351323, PMID 26808342, PMID 26942088, PMID 27941097, PMID 28194539, PMID 28744123, PMID 29186019, PMID 30184767, PMID 30227893, PMID 30446785, PMID 30545649, PMID 30627694, PMID 32385714, PMID 32502336, PMID 32510916, PMID 32736411, PMID 32809217, PMID 32918045, PMID 32939607, PMID 33060149, PMID 33145616, PMID 33207944, PMID 33355229, PMID 33420642, PMID 33589520, PMID 33602696, PMID 34031756, PMID 34032893, PMID 34040174, PMID 34040175, PMID 34045232, PMID 34059639
2023 (18), 2025 (8), 2019 (5), 2017 (4), 2018 (2), 2009 (1), 2014 (1), 2015 (1), 2016 (1), P41EB013598 (1), R01CA225913 (1), R01CA229354 (1), R01CA256740 (1), R01CA258297 (1), R44CA250824 (1)