6 completed, 3 recruiting, 2 terminated, 1 unknown. 8 Phase 1, 6 Phase 2, 1 Phase 3.
By phase and status
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
A Study of PEP08 in Patients With MTAP-Del Advanced or Metastatic Solid Tumors PEP08 - Advanced Solid Tumor, Solid Tumors | Phase 1 | Recruiting | 40 | 2025-08-26 | 2026-02-13 |
A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients with Advanced or Metastatic Solid Tumors PEP07 - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Recruiting | 54 | 2024-03-27 | 2024-11-07 |
A Study of PEP07 (Checkpoint Kinase 1 Inhibitor) in Patients With Advanced Cancer PEP07 - Acute Myeloid Leukemia, Lymphoma, Mantle-Cell | Phase 1 | Recruiting | 32 | 2023-07-17 | 2025-07-31 |
Nanoliposomal Irinotecan (Nal-IRI, ONIVYDE®) in Combination With TAS-102 (LONSURF®) in Refractory Solid Tumors Nanoliposomal Irinotecan - Refractory Solid Tumors | Phase 1 | Completed | 44 | 2019-03-05 | 2023-11-18 |
A Study of PEP503 With Radiotherapy in Combination With Concurrent Chemotherapy for Patients With Head and Neck Cancer PEP503, Cisplatin, Radiotherapy - Head and Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Terminated | 12 | 2016-10-11 | 2022-01-11 |
A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With Rectal Cancer PEP503, 5-fluorouracil, capecitabine - Rectal Cancer | Phase 1 / Phase 2 | Terminated | 32 | 2015-06-01 | 2022-01-11 |
NBTXR3 Crystalline Nanoparticles and Radiation Therapy in Treating Randomized Patients in Two Arms With Soft Tissue Sarcoma of the Extremity and Trunk Wall NBTXR3, Radiation therapy - Adult Soft Tissue Sarcoma | Phase 2 / Phase 3 | Completed | 180 | 2015-03-03 | 2021-04-06 |
Phase I and Pharmacokinetic Study of Biweekly PEP02 in mCRC Refractory to 1st-line Oxaliplatin Base Therapy PEP02 - Metastatic Colorectal Cancer | Phase 1 | Completed | 18 | 2009-06-01 | 2017-04-06 |
Study of PEP02 as a Second Line Therapy for Metastatic Pancreatic Cancer PEP02 - Pancreatic Neoplasms | Phase 2 | Completed | 41 | 2009-01-01 | 2019-09-06 |
Study of PEP02, Irinotecan or Docetaxel in Gastric or Gastroesophageal Junction Adenocarcinoma PEP02, irinotecan, docetaxel - Stomach Neoplasms, Esophageal Neoplasms | Phase 2 | Completed | 135 | 2007-11-01 | 2012-03-02 |
A Study of PEP02 in Combination With 5-fluorouracil (5-FU) and Leucovorin (LV) in Advanced Solid Tumors PEP02, 5-FU, LV - Solid Tumor | Phase 1 | Completed | 16 | 2006-01-01 | 2016-08-30 |
Two-Stage Study to Assess the Efficacy and Safety of 12 Weeks of Treatment With PEP03 in Patients With Chronic Obstructive Pulmonary Disease (COPD) PEP03 - COPD | Phase 2 | Unknown | | 2004-09-01 | 2005-09-22 |
Conditions studied
Neoplasm Metastasis (3) · Adenocarcinoma (1) · Colorectal Neoplasms (1) · Esophageal Neoplasms (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Mantle-Cell (1) · Pancreatic Neoplasms (1) · Pulmonary Disease, Chronic Obstructive (1) · Rectal Neoplasms (1) · Sarcoma (1) · Squamous Cell Carcinoma of Head and Neck (1) · Stomach Neoplasms (1)
Interventions
Radiotherapy (3) · Fluorouracil (2) · irinotecan sucrosofate (2) · Capecitabine (1) · Cisplatin (1) · Docetaxel (1) · Irinotecan (1) · Leucovorin (1) · trifluridine tipiracil drug combination (1)
Countries
Taiwan (10) · Australia (3) · Spain (2) · Belgium (1) · Bosnia and Herzegovina (1) · Croatia (1) · France (1) · Germany (1) · Hong Kong (1) · Hungary (1) · Italy (1) · Norway (1) · Philippines (1) · Poland (1) · Romania (1)
Top investigators
Andrew H Ko, M.D. (1) · Cheng-Hsu Wang, M.D. (1) · Chia-Chi Lin, MD (1) · David Cunningham (1) · Hsin-An Hou, M.D. (1) · Jwa-Yuan Wang, phD (1) · Li-Tzong Chen, M.D. (1) · Yu-Lin Lin, M.D. (1)
Results publications
PMID 19525947, PMID 23406728, PMID 23880820, PMID 27871319, PMID 31296491, PMID 37166053, PMID 40255171