12 terminated. 12 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Terminated 12 |
| Phase 2 | 4 | Terminated 4 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Xevinapant With Radiation and Chemotherapy for Patients With Head and Neck Cancer Xevinapant, Carboplatin, Paclitaxel - Head and Neck Cancer, Head and Neck Neoplasms | Phase 1 | Terminated | University of Chicago | 42 | 2024-01-24 | 2026-03-31 |
| Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors avelumab, Bempegaldesleukin, talazoparib - Squamous Cell Carcinoma of the Head and Neck (SCCHN), Metastatic Castration Resistant Prostate Cancer (mCRPC) | Phase 1 / Phase 2 | Terminated | Pfizer | 3 | 2019-12-30 | 2021-10-14 |
| Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery Avelumab, Trabectedin - Metastatic Leiomyosarcoma, Metastatic Liposarcoma | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 35 | 2017-09-28 | 2022-04-29 |
| Localized Radiation Therapy or Recombinant Interferon Beta and Avelumab With or Without Cellular Adoptive Immunotherapy in Treating Patients With Metastatic Merkel Cell Carcinoma Avelumab, Laboratory Biomarker Analysis, MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells - Merkel Cell Polyomavirus Infection, Stage IV Merkel Cell Carcinoma AJCC v7 | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 8 | 2015-11-06 | 2022-03-22 |
| Sym004 in Subjects With Stage IV Non-small Cell Lung Cancer Part 1: Sym004 6 mg/kg + Cisplatin/Gemcitabine, Part 1: Sym004 6 mg/kg + Cisplatin/Pemetrexed, Part 1: Sym004 6 mg/kg + Carboplatin/Paclitaxel - Carcinoma, Non-Small-Cell Lung | Phase 1 | Terminated | EMD Serono | 15 | 2014-07-01 | 2016-10-25 |
| MSC2015103B in Solid Tumors MSC2015103B - Advanced Solid Tumor | Phase 1 | Terminated | EMD Serono | 28 | 2011-09-01 | 2017-05-08 |
| Atacicept in Lupus Nephritis Patients Taking Stable Regimen of Mycophenolate Mofetil Atacicept - Lupus Nephritis | Phase 1 | Terminated | EMD Serono | 1 | 2011-06-01 | 2013-10-22 |
| Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus Pimasertib, Temsirolimus - Advanced Solid Tumor | Phase 1 | Terminated | EMD Serono | 33 | 2011-05-27 | 2018-07-30 |
| First-in-Man, Dose-escalation Trial of c-Met Kinase Inhibitor EMD 1204831 in Subjects With Advanced Solid Tumors EMD 1204831 - Solid Tumors | Phase 1 | Terminated | EMD Serono | 38 | 2010-04-01 | 2013-10-22 |
| MEK Inhibitor MSC1936369B Plus FOLFIRI in Second Line K-Ras Mutated Metastatic Colorectal Cancer (mCRC) Pimasertib, Placebo, FOLFIRI - Metastatic Colorectal Cancer | Phase 1 / Phase 2 | Terminated | EMD Serono | 16 | 2010-03-01 | 2016-10-19 |
| Study of FOLFIRI Plus Cetuximab Plus IMO-2055 in Patients With Colorectal Cancer IMO-2055, Cetuximab, FOLFIRI - Colorectal Cancer | Phase 1 | Terminated | EMD Serono | 21 | 2009-01-01 | 2013-10-22 |
| A Phase I, Dose-escalation Study of AS703569 Given Orally to Subjects With Haematological Malignancies AS703569 - Haematological Malignancies | Phase 1 | Terminated | EMD Serono | 124 | 2006-12-01 | 2013-10-22 |
Colorectal Neoplasms (2) · Squamous Cell Carcinoma of Head and Neck (2) · Carcinoma, Merkel Cell (1) · Carcinoma, Non-Small-Cell Lung (1) · Head and Neck Neoplasms (1) · Leiomyosarcoma (1) · Liposarcoma (1) · Lupus Nephritis (1) · Neoplasm Metastasis (1) · Neoplasms (1)
avelumab (3) · Carboplatin (2) · IFL protocol (2) · N-(2,3-dihydroxypropyl)-1-((2-fluoro-4-iodophenyl)amino)isonicotinamide (2) · Paclitaxel (2) · Radiotherapy (2) · 4-(2-(2-(3-(3-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1,6-dihydropyridazin-1-ylmethyl)phenyl)pyrimidin-5-yloxy)ethyl)morpholine (1) · Cetuximab (1) · Cisplatin (1) · Gemcitabine (1) · IMO-2055 (1) · Interferon-beta (1) · MSC1992371A (1) · Pemetrexed (1) · Radiation (1)
United States (11) · Belgium (3) · Germany (2) · Italy (2) · Spain (2) · Poland (1) · Switzerland (1)
Ari Rosenberg, ND (1) · Aude Chapuis (1) · Manfred Klevasath, MD (1) · Narmyn Rejeb, M.D. (1) · Phil Breitfeld, MD (1) · Seth Pollack (1)
PMID 23746966, PMID 24668327, PMID 25627002, PMID 28194539
P30CA015704 (2), 2019 (1), K24CA139052 (1), R01CA176841 (1)