5 completed, 2 recruiting, 1 withdrawn. 4 Phase 3, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Recruiting 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Linezolid Tolerance During the BPaL Regimen With Dosage Personalization Based on Therapeutic Drug Monitoring (TDM) During Multidrug-Resistant Tuberculosis Treatment Linezolid dose personalization based on TDM - Linezolid, Tuberculosis Multi Drug Resistant Active | Phase 4 | Recruiting | Marco Schiuma | 150 | 2026-04-01 | 2026-05-13 |
| Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy (Phase 2) BE-PEP (Bedaquiline), SDR-PEP, BE-PEP (Rifampicine) - Leprosy | Phase 2 | Completed | Institute of Tropical Medicine, Belgium | 313 | 2022-07-14 | 2024-08-28 |
| Novel Triple-dose Tuberculosis Retreatment Regimen 6EH³R³Z, 6EHRZ - Multidrug-resistant Tuberculosis, Pulmonary Tuberculosis | Phase 3 | Recruiting | Institute of Tropical Medicine, Belgium | 370 | 2021-03-01 | 2025-04-13 |
| Novel Triple-dose Tuberculosis Retreatment Regimens: How to Overcome Resistance Without Creating More 6EH³RZ, 6EHR³Z, 6EHRZLfx - Tuberculosis, Pulmonary | Phase 3 | Withdrawn | Institute of Tropical Medicine, Belgium | 2019-09-30 | 2020-01-21 | |
| Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar Rifampicin - Leprosy | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 144000 | 2019-01-02 | 2025-03-04 |
| DIAgnostics for Multidrug Resistant Tuberculosis in Africa Deeplex test, MolBio TrueNat for 2nd line, GeneXpert 2nd line, Fluorescein DiAcetate (FDA) Microscopy,GeneXpert Ct value, pre-rRNA synthesis - Tuberculosis, Multidrug-Resistant | Completed | Dissou AFFOLABI | 3356 | 2017-05-04 | 2023-03-14 | |
| Improved Understanding of Ongoing Transmission of Leprosy in the Hyperendemic Comoros (ComLep) Leprosy | Completed | Institute of Tropical Medicine, Belgium | 889 | 2017-04-01 | 2021-05-11 | |
| Optimization of the TB Treatment Regimen Cascade double rimfampicin, Standard TB treatment - Tuberculosis, Pulmonary | Phase 3 | Completed | Damien Foundation | 701 | 2014-11-01 | 2020-02-13 |
Leprosy (3) · Tuberculosis (3) · Tuberculosis, Multidrug-Resistant (3) · Tuberculosis, Pulmonary (3) · Disease (1) · Drug-Related Side Effects and Adverse Reactions (1) · Peripheral Nervous System Diseases (1)
Rifampin (3) · Ethambutol (1) · Isoniazid (1) · Microscopy (1) · Pyrazinamide (1) · bedaquiline (1)
Comoros (3) · Bangladesh (2) · Guinea (2) · Belgium (1) · Benin (1) · Cameroon (1) · Democratic Republic of the Congo (1) · Ethiopia (1) · Madagascar (1) · Mali (1) · Niger (1) · Nigeria (1) · Rwanda (1) · Senegal (1)
Aung Kya Jai Maug, MD (1) · Bertrand Cauchoix, MD (1) · Bouke C de Jong, MD,PhD (1) · Bouke de Jong, MD, PhD (1) · Epco Hasker, MD (1) · Marco Schiuma (1) · Sani Kadri (1) · Souleymane Hassane Harouna (1) · Tom Decroo, MD (1) · Younoussa Assoumani (1) · Younoussa Assoumani, MD (1)
PMID 35850123, PMID 20442432, PMID 25097082, PMID 25216831, PMID 25216832, PMID 31805862, PMID 35583175, PMID 38762282, PMID 39432509, PMID 40122135