74 completed, 44 terminated, 10 active not recruiting, 9 withdrawn. 150 Phase 2, 60 Phase 1, 3 Phase 3.
Follow Vorinostat: new trials by email Literature Review of Vorinostat trials Research Report on Vorinostat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NANT 2021-02: Randomized MIBG With Vorinostat/Dinutuximab/Vorinostat + Dinutuximab Radiation: 131I-MIBG, Dinutuximab, Vorinostat - Neuroblastoma | Phase 2 | Not yet recruiting | New Approaches to Neuroblastoma Therapy Consortium | 118 | 2026-12-31 | 2026-08-21 |
| Vorinostat for Graft-versus-host Disease (GVHD) Prevention in Non-Malignant Adolescent and Young Adults (AYA) Population Vorinostat - GVHD | Phase 2 | Recruiting | Sung Won Choi | 55 | 2026-12-01 | 2026-10-16 |
| Safety and Effectiveness of A-dmDT390-bisFv(UCHT1) Fusion Protein in Subjects With Mycosis Fungoides A-dmDT390-bisFv(UCHT1), Vorinostat - Mycosis Fungoides | Phase 2 | Withdrawn | Virogen Biotechnology Inc. | 2026-05-01 | 2026-05-18 | |
| Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC Cisplatin, Radiation therapy, Vorinostat - HPV-Related Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Oral Cavity | Phase 2 | Withdrawn | Case Comprehensive Cancer Center | 2025-06-01 | 2025-04-04 | |
| Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease Vorinostat - Cushing's Disease | Phase 2 | Withdrawn | National Institute of Neurological Disorders and Stroke (NINDS) | 2025-04-11 | 2025-04-15 | |
| Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer Biopsy Procedure, Biospecimen Collection, Bone Scan - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 15 | 2024-09-18 | 2026-08-06 |
| TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II Dexamethasone, Mitoxantrone, PEG asparaginase - Lymphoblastic Leukemia | Phase 1 / Phase 2 | Recruiting | Tanja Andrea Gruber | 90 | 2023-11-03 | 2026-06-03 |
| Vorinostat and Combination Chemotherapy Before Donor Stem Cell Transplantation for the Treatment of Relapsed Aggressive B-cell or T-cell Non-Hodgkin Lymphoma Allogeneic Hematopoietic Stem Cell Transplantation, Busulfan, Clofarabine - Recurrent Aggressive Non-Hodgkin Lymphoma, Recurrent B-Cell Non-Hodgkin Lymphoma | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2021-10-29 | 2024-01-12 | |
| Pembrolizumab and Tamoxifen With or Without Vorinostat for the Treatment of Estrogen Receptor Positive Breast Cancer Pembrolizumab, Tamoxifen, Vorinostat - Anatomic Stage IV Breast Cancer AJCC v8, Prognostic Stage IV Breast Cancer AJCC v8 | Phase 2 | Terminated | University of California, San Francisco | 1 | 2021-03-11 | 2023-08-31 |
| Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations pembrolizumab; vorinostat - Squamous Cell Lung Cancer, Vulvar Cancer | Phase 2 | Completed | UNICANCER | 112 | 2020-10-28 | 2025-02-19 |
| Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation Vorinostat, Blood and Marrow Transplant (BMT), Tacrolimus (or cyclosporine) - Hematologic Diseases, Acute Leukemia in Remission | Phase 1 / Phase 2 | Active not recruiting | University of Michigan Rogel Cancer Center | 43 | 2020-02-04 | 2026-01-27 |
| A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects 131I-MIBG, 131-MIBG + Vorinostat - Neuroblastoma, Neuroectodermal Tumors | Phase 2 | Unknown | Jubilant DraxImage Inc. | 60 | 2019-10-21 | 2023-02-16 |
| SOLAR: Efficacy and Safety of Cobomarsen (MRG-106) vs. Active Comparator in Subjects With Mycosis Fungoides Cobomarsen, Vorinostat - Cutaneous T-Cell Lymphoma/Mycosis Fungoides | Phase 2 | Terminated | miRagen Therapeutics, Inc. | 37 | 2019-04-02 | 2022-04-08 |
| Voronistat in Pediatric Patients With Drug Resistant Epilepsy Vorinostat 100 MG - Refractory Epilepsy | Phase 2 | Unknown | University of Calgary | 12 | 2018-12-10 | 2019-03-29 |
| Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase Inhibitors Tamoxifen, Vorinostat, Antiretroviral drugs - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 31 | 2018-04-26 | 2024-07-03 |
| Vorinostat (SAHA) in Uterine Sarcoma Vorinostat Oral Capsule - Leiomyosarcoma, Endometrial Stromal Tumors | Phase 2 | Terminated | Medical University of Graz | 3 | 2017-12-14 | 2020-08-04 |
| An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab Vorinostat, Ustekinumab - Crohn's Disease | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 35 | 2017-10-30 | 2026-11-02 |
| Combination Latency Reversal With High Dose Disulfiram Plus Vorinostat in HIV-infected Individuals on ART Disulfiram, (National Drug Code) NDC 0378-4141-01, Vorinostat, NDC 00006-0568-40 - HIV Infections | Phase 1 / Phase 2 | Terminated | University of Melbourne | 5 | 2017-08-08 | 2024-02-09 |
| Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma Prednisone, Vincristine, Daunorubicin - Acute Lymphoblastic Leukemia, Acute Lymphoblastic Lymphoma | Phase 2 / Phase 3 | Active not recruiting | St. Jude Children's Research Hospital | 790 | 2017-03-29 | 2026-06-17 |
| Lenalidomide Combined With Vorinostat/Gemcitabine/Busulfan/Melphalan With Autologous Stem-Cell Transplantation in Diffuse Large B-Cell Lymphoma of the ABC Subtype Lenalidomide, Vorinostat, Gemcitabine - Lymphoma | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 8 | 2016-06-22 | 2019-12-13 |
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Lymphoma (14) · Breast Neoplasms (12) · Leukemia, Myeloid, Acute (12) · Lymphoma, Large B-Cell, Diffuse (10) · Lymphoma, Mantle-Cell (10) · Myelodysplastic Syndromes (10) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (10) · Lymphoma, Non-Hodgkin (9) · Carcinoma, Non-Small-Cell Lung (8) · Glioblastoma (8) · Lymphoma, Follicular (8) · Leukemia (7) · Multiple Myeloma (7) · Brain Neoplasms (6) · Lymphoma, B-Cell, Marginal Zone (6)
National Cancer Institute (NCI) (36) · M.D. Anderson Cancer Center (11) · Merck Sharp & Dohme LLC (9) · Fred Hutchinson Cancer Center (5) · Masonic Cancer Center, University of Minnesota (4) · University of Washington (4) · St. Jude Children's Research Hospital (3) · Dana-Farber Cancer Institute (2) · Groupe Francophone des Myelodysplasies (2) · H. Lee Moffitt Cancer Center and Research Institute (2) · Hackensack Meridian Health (2) · Memorial Sloan Kettering Cancer Center (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · New Approaches to Neuroblastoma Therapy Consortium (2) · Samsung Medical Center (2)
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Evanthia Galanis (3) · Leona Holmberg (2) · Michael Burke, MD (2) · Pamela Munster, MD (2) · Pavan Reddy, MD (2) · Roland Walter (2) · Yago Nieto, MD, PHD (2) · Alexander N Shoushtari (1) · Amelia Insa, MD (1) · Andrei Shustov (1) · Anne Traynor (1) · Antonio Palumbo, MD (1) · Armando Santoro, MD (1)
PMID 34389161, PMID 32632956, PMID 18854394, PMID 19213682, PMID 19590405, PMID 19794082, PMID 19834480, PMID 19951879, PMID 21300924, PMID 22133771, PMID 22200869, PMID 22472858, PMID 22836995, PMID 22837004, PMID 22915450, PMID 22952756, PMID 22999944, PMID 23233571, PMID 23516360, PMID 23953882, PMID 24142996, PMID 24295572, PMID 24464266, PMID 24617454, PMID 24620025, PMID 24636848, PMID 24891274, PMID 25393648, PMID 25476537, PMID 25596263, PMID 25795722, PMID 26119093, PMID 26521238, PMID 27025160, PMID 27367154, PMID 27795561, PMID 28301423, PMID 28714868, PMID 28918548, PMID 29133513, PMID 29373639, PMID 29618479, PMID 30830886, PMID 31177537, PMID 31386061, PMID 31796519, PMID 31823832, PMID 31969338, PMID 32085823, PMID 32125175
N01CM62209 (6), P30CA015704 (5), N01CM62204 (4), N01CM62205 (4), P30CA033572 (4), 2008 (3), N01CM00100 (3), N01CM62201 (3), N01CM62206 (3), P30CA006973 (3), U01CA062491 (3), U10CA025224 (3), U10CA032102 (3), N01CM00038 (2), N01CM00071 (2)