Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma

NCT00629486 — Not applicable, Completed, 300 participants, Kaohsiung Medical University Chung-Ho Memorial Hospital

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Registry	NCT00629486
Status	Completed
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, basic science
Enrollment	300 (Actual)
Sponsor	Kaohsiung Medical University Chung-Ho Memorial Hospital (Other)
Conditions	Hepatitis B, Hepatocellular Carcinoma, Chronic Liver Disease
Interventions	Polymorphism of IL-1 beta and TNF-alpha (Genetic)
Dates	start 2007-01-01, primary completion 2008-05-01, completion 2008-05-01, first posted 2008-03-06, last updated 2013-04-18
Locations	2 sites in Taiwan

-Summary

By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.

Expand all sections · Collapse all

+Detailed description

Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated liver damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in inflammatory responses and account for heterogeneous disease outcome of infectious disease.

By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.

+Arms and interventions

Arm	Type	Interventions	Description
cytokines were determined	Experimental	Genetic: Polymorphism of IL-1 beta and TNF-alpha	prevalence of genetic polymorphisms of interleukin 1B was measured in HBV-related hepatocellular carcinoma

Polymorphism of IL-1 beta and TNF-alpha (Genetic), also known as polymorphism, TNF-alpha, interleukin-1L: To analyze the role of polymorphisms of IL-1beta and TNF-alpha gene on risk of hepatitis B-related chronic liver disease and hepatocellular carcinoma

+Outcome measures

Primary outcomes

cytokine polymorphisms increase risk for hepatocellular carcinoma [years]

+Eligibility

Sex: All, accepts healthy volunteers

Inclusion Criteria:

* HBsAg-positive patients

Exclusion Criteria:

* HBsAg-negative patients

+Locations (2)

Facility	City	Country	Status
Kaohsiung Medical University Chung-Ho Hospital	Kaohsiung City, Kaohsiung	Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital	Kaohsiung City, Kaohsiung	Taiwan

+Investigators

Jung-Fa Tsai, M.D., Ph.D., Principal investigator, Professor of Medicine