16 completed, 1 terminated. 6 Phase 3, 4 Not applicable, 4 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 5, Terminated 1 |
| Not applicable | 4 | Completed 4 |
| Phase 2 | 4 | Completed 4 |
| Phase 1 | 3 | Completed 3 |
Follow trimetrexate glucuronate: new trials by email Literature Review of trimetrexate glucuronate trials Research Report on trimetrexate glucuronate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma leucovorin calcium, methotrexate, trimetrexate glucuronate - Sarcoma | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 18 | 2005-04-01 | 2013-01-17 |
| Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma filgrastim, cisplatin, doxorubicin hydrochloride - Sarcoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 1998-12-01 | 2013-06-21 | |
| Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer fluorouracil, leucovorin calcium, trimetrexate glucuronate - Colorectal Cancer | Phase 2 | Completed | Grupo Oncologico Cooperativo del Sur | 1997-12-01 | 2013-06-26 | |
| Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia, Osteosarcoma, or Non-Hodgkin's Lymphoma leucovorin calcium, trimetrexate glucuronate - Leukemia, Lymphoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 25 | 1996-01-01 | 2013-03-07 |
| Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas fluorouracil, leucovorin calcium, trimetrexate glucuronate - Pancreatic Cancer | Phase 2 | Completed | University of Southern California | 21 | 1995-08-01 | 2014-05-22 |
| A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2008-09-30 | ||
| Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Trimetrexate glucuronate, Sulfamethoxazole-Trimethoprim, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 302 | 2021-11-04 | |
| A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Not applicable | Completed | U.S. Bioscience | 2005-06-24 | ||
| A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia. Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Not applicable | Completed | U.S. Bioscience | 2005-06-24 | ||
| A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 50 | 2021-11-04 | |
| An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2021-10-29 | ||
| A Study of Trimetrexate Plus Leucovorin in Children With Pneumocystis Carinii Pneumonia Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Not applicable | Completed | U.S. Bioscience | 2005-06-24 | ||
| A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2012-12-19 | ||
| Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Trimetrexate glucuronate, Pentamidine isethionate, Sulfamethoxazole-Trimethoprim - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 364 | 2021-11-04 | |
| Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients Trimetrexate glucuronate, Methylprednisolone, Pentamidine isethionate - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 3 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 240 | 2021-11-03 | |
| Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia Trimetrexate glucuronate, Trimethoprim, Sulfamethoxazole - Pneumonia, Pneumocystis Carinii, HIV Infections | Phase 1 | Completed | U.S. Bioscience | 20 | 2005-06-24 | |
| A Study of Neutrexin Plus Leucovorin in the Treatment of Pneumocystis Carinii Pneumonia (PCP) Trimetrexate glucuronate, Leucovorin calcium - Pneumonia, Pneumocystis Carinii, HIV Infections | Not applicable | Completed | U.S. Bioscience | 2005-06-24 |
Acquired Immunodeficiency Syndrome (12) · HIV Infections (12) · Pneumonia, Pneumocystis (12) · AIDS-Related Opportunistic Infections (5) · AIDS-Related Complex (3) · Osteosarcoma (3) · Sarcoma (3) · Burkitt Lymphoma (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1) · Dendritic Cell Sarcoma, Interdigitating (1) · Leukemia (1) · Lymphoma (1) · Pancreatic Neoplasms (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
National Institute of Allergy and Infectious Diseases (NIAID) (7) · U.S. Bioscience (5) · Memorial Sloan Kettering Cancer Center (3) · Grupo Oncologico Cooperativo del Sur (1) · University of Southern California (1)
United States (16) · Argentina (1)
Feinberg J (5) · Masur H (2) · Sattler FR (2) · Agustin Garcia, MD (1) · Juan Eduardo Perez, MD (1) · Paul A. Meyers, MD (1) · Richard Gorlick, MD (1) · Tanya Trippett, MD (1)
P30CA008748 (1)