104 completed, 21 terminated, 10 recruiting, 7 unknown. 152 Phase 1, 38 Phase 2.
Follow Topotecan: new trials by email Literature Review of Topotecan trials Research Report on Topotecan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of Iberdomide to Therapy in People With Neuroblastoma That Has Come Back, Not Responded to Treatment, or Gotten Worse Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography - Recurrent Ganglioneuroblastoma, Recurrent Neuroblastoma | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 76 | 2027-06-25 | 2026-10-22 |
| The Safety and Efficacy of Intravitreal Topotecan for the Treatment of Proliferative Vitreoretinopathy Topotecan - Proliferative Vitreoretinopathy, Proliferative Vitreo-Retinopathy | Phase 1 | Not yet recruiting | Massachusetts Eye and Ear Infirmary | 50 | 2026-12-01 | 2026-10-16 |
| Chronic CED of TPT for Recurrent Malignant Glioma Topotecan - Brain Tumor, Recurrent, Malignant Glioma (WHO Grade III or IV) | Phase 1 | Recruiting | Jeffrey N. Bruce | 6 | 2026-06-12 | 2026-06-15 |
| Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer NMS-03305293, Topotecan - Ovarian Cancer | Phase 1 | Recruiting | Nerviano Medical Sciences | 24 | 2026-05-13 | 2026-05-28 |
| Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes Vincristine, Doxorubicin, Cyclophosphamide - Metastatic Ewing Sarcoma | Phase 1 | Recruiting | H. Lee Moffitt Cancer Center and Research Institute | 15 | 2026-02-05 | 2026-09-25 |
| An Umbrella Study of Recurrent, Extensive Stage Small Cell Lung Cancer Based on Molecular Typing Serplulimab, Fluzoparib, Topotecan/Irinotecan/Paclitaxel/Temozolomide - SCLC, Extensive Stage | Phase 1 / Phase 2 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 100 | 2025-12-31 | 2025-08-26 |
| A Study of PHST001 in Advanced Solid Tumors PHST001, Paclitaxel, Topotecan - Advanced Solid Tumors, Ovarian Cancer | Phase 1 | Recruiting | Pheast Therapeutics | 426 | 2025-03-31 | 2026-10-05 |
| A Multi-Arm, Platform Trial For Relapsed Neuroblastoma Bevacizumab, Dinutuximab beta, Irinotecan (drug) - Relapsed Neuroblastoma | Phase 1 / Phase 2 | Recruiting | University of Birmingham | 160 | 2024-11-11 | 2026-01-12 |
| DAREON™-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With a Single Agent Chemotherapy BI 764532, Topotecan, Single agent chemotherapy - Small Cell Lung Carcinoma (SCLC) | Phase 1 | Active not recruiting | Boehringer Ingelheim | 69 | 2024-02-14 | 2026-09-15 |
| A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study) Peluntamig (PT217), Carboplatin + Etoposide, Paclitaxel. - Small Cell Lung Cancer (SCLC), Large Cell Neuroendocrine Cancer (LCNEC) | Phase 1 / Phase 2 | Recruiting | Phanes Therapeutics | 203 | 2023-09-05 | 2026-07-15 |
| Intra-Arterial Chemotherapy for Newly Diagnosed, Residual, or Recurrent Atypical Choroid Plexus Papilloma and Choroid Plexus Carcinoma Prior to Second-Look Surgery Melphalan, Carboplatin, Topotecan - Atypical Choroid Plexus Papilloma, Choroid Plexus Carcinoma | Phase 1 | Terminated | Weill Medical College of Cornell University | 1 | 2023-05-04 | 2026-06-08 |
| Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i) Dapagliflozin, Carmustine, Topotecan - Pediatric Brain Tumor, Pediatric Solid Tumor | Phase 1 | Recruiting | Washington University School of Medicine | 20 | 2023-04-03 | 2026-06-10 |
| Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy Talazoparib, Topotecan, Gemcitabine - Acute Myeloid Leukemia | Phase 1 | Recruiting | Norman J. Lacayo | 34 | 2023-02-23 | 2026-04-22 |
| Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors Topotecan, Temozolomide, Ribociclib - Neuroblastoma | Phase 1 | Terminated | Novartis Pharmaceuticals | 12 | 2022-12-27 | 2025-10-10 |
| Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Extensive Stage Lung Small Cell Carcinoma, Limited Stage Lung Small Cell Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 18 | 2022-07-27 | 2026-05-13 |
| Berzosertib Human Mass Balance Study (DDRiver Solid Tumors 208) [14C]Berzosertib, Berzosertib, Topotecan - Advanced Solid Tumor | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 6 | 2022-02-15 | 2024-11-22 |
| A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577) Seclidemstat - Ewing Sarcoma, Myxoid Liposarcoma | Phase 1 / Phase 2 | Unknown | Salarius Pharmaceuticals, LLC | 10 | 2022-01-15 | 2023-08-01 |
| Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Solid Neoplasm | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 29 | 2021-10-20 | 2026-09-10 |
| Reducing Hypoxia in Patients With Coronavirus Disease (COVID-19) Using Topotecan With Standard of Care Topotecan - COVID-19 Respiratory Infection | Phase 1 | Unknown | National University Hospital, Singapore | 24 | 2021-08-16 | 2021-11-04 |
| Cabozantinib With Topotecan-Cyclophosphamide Cabozantinib, Topotecan, Cyclophosphamide - Relapsed Ewing Sarcoma, Refractory Ewing Sarcoma | Phase 1 | Completed | Dana-Farber Cancer Institute | 12 | 2020-12-23 | 2023-02-15 |
Showing 20 of 152. Sign in to see all of them.
Ovarian Neoplasms (33) · Small Cell Lung Carcinoma (22) · Neoplasms (19) · Carcinoma, Ovarian Epithelial (17) · Neuroblastoma (16) · Fallopian Tube Neoplasms (15) · Lung Neoplasms (14) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (12) · Leukemia (11) · Leukemia, Myeloid, Acute (10) · Uterine Cervical Neoplasms (10) · Recurrence (9) · Neoplasm Metastasis (8) · Brain Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (6)
National Cancer Institute (NCI) (19) · GlaxoSmithKline (7) · H. Lee Moffitt Cancer Center and Research Institute (7) · Children's Oncology Group (5) · M.D. Anderson Cancer Center (4) · NYU Langone Health (4) · SCRI Development Innovations, LLC (4) · City of Hope Medical Center (3) · Gynecologic Oncology Group (3) · Mayo Clinic (3) · New Approaches to Neuroblastoma Therapy Consortium (3) · Yale University (3) · Accelerated Community Oncology Research Network (2) · Case Comprehensive Cancer Center (2) · Columbia University (2)
United States (127) · Canada (12) · United Kingdom (10) · France (9) · Australia (7) · Germany (5) · Italy (5) · Netherlands (5) · Belgium (4) · Spain (4) · Bosnia and Herzegovina (2) · Denmark (2) · New Zealand (2) · Poland (2) · Serbia (2)
Howard S. Hochster, MD (5) · Jeffrey Bruce, MD (3) · Anish Thomas, M.D. (2) · Brenda W. Cooper, MD (2) · Howard A. Burris, MD (2) · Alan F. List, MD (1) · Amy D. Tiersten, MD (1) · Anders Jakobsen, MD, DMSc (1) · Andrea E Wahner Hendrickson (1) · Andrew Cluster, M.D. (1) · Andrew S. Kraft, MD (1) · Angela Davies, MD (1) · Anish Thomas (1)
PMID 42820295, PMID 11896112, PMID 15013589, PMID 16150481, PMID 16412499, PMID 16631245, PMID 17336213, PMID 18096059, PMID 18191187, PMID 18978345, PMID 19238149, PMID 19427025, PMID 19648970, PMID 20347480, PMID 20558056, PMID 21620511, PMID 21795476, PMID 21910214, PMID 22010014, PMID 23240851, PMID 24327518, PMID 24849582, PMID 27424289, PMID 28053024, PMID 28672195, PMID 29252124, PMID 29383130, PMID 29846250, PMID 30104007, PMID 31101621, PMID 31401903, PMID 31533931, PMID 31538815, PMID 31831767, PMID 31882719, PMID 33037105, PMID 33095287, PMID 33123968, PMID 33595690, PMID 33892407, PMID 33909232, PMID 34028986, PMID 34347542, PMID 34405547, PMID 34408488, PMID 34486544, PMID 34543871, PMID 34562230, PMID 34965890, PMID 35292802
P30CA043703 (3), U01CA069912 (3), U10CA180886 (3), 2016 (2), P30CA015083 (2), P30CA016087 (2), P30CA033572 (2), U10CA098543 (2), 2008 (1), 2009 (1), 2018 (1), 2019 (1), 2023 (1), M01RR000096 (1), P01CA081403 (1)