8 completed, 7 unknown, 2 recruiting, 1 not yet recruiting. 9 Not applicable, 6 Phase 4, 2 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 4, Unknown 4, Not yet recruiting 1 |
| Phase 4 | 6 | Completed 3, Recruiting 2, Unknown 1 |
| Phase 3 | 2 | Unknown 2 |
| Phase 2 | 1 | Completed 1 |
Follow Topical tranexamic acid: new trials by email Literature Review of Topical tranexamic acid trials Research Report on Topical tranexamic acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Effectiveness and Safety of Microneedling With Topical Tranexamic Acid in Treatment of Striae Rubra Topical tranexamic acid, normal saline (0.9% NaCl) - Striae Rubra | Not applicable | Not yet recruiting | Sohag University | 50 | 2026-10-01 | 2026-09-10 |
| Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery IV TXA, Topical TXA, Topical saline - Drain Output After Breast Reduction Surgery, Breast Reductions | Phase 4 | Recruiting | Massachusetts General Hospital | 160 | 2025-11-18 | 2026-01-16 |
| Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation Topical TRanexamic Acid, Placebo - Distal Radius Fractures | Phase 4 | Recruiting | University Health Network, Toronto | 90 | 2025-08-13 | 2026-05-04 |
| Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa Topical tranexamic acid, Intravenous tranexamic acid - Placenta Previa | Not applicable | Unknown | Cairo University | 56 | 2024-07-24 | 2024-07-23 |
| Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women Undergoing Elective Cesarean Section Topical tranexamic acid, : normal saline - Cesarean Section Complications | Not applicable | Unknown | Aswan University Hospital | 150 | 2021-10-01 | 2021-10-11 |
| Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women With Twin Pregnancy Topical tranexamic acid, normal saline - Cesarean Section Complications | Not applicable | Unknown | Aswan University Hospital | 150 | 2021-10-01 | 2021-10-11 |
| Tranexamic Acid in Pregnant Women Undergoing Cesarean Section. Topical tranexamic acid, normal saline - Cesarean Section Complications | Not applicable | Completed | Aswan University Hospital | 180 | 2019-01-01 | 2023-04-04 |
| Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery BUA, topical tranexamic acid, placebo - Cesarean Section Complications | Not applicable | Unknown | Aswan University Hospital | 100 | 2018-12-01 | 2019-01-10 |
| Reducing Blood Loss During Cesarean Section by Topical Versus IV Tranexamic Acid normal saline arm group, intravenous tranexamic acid, Topical tranexamic acid - Cesarean Section Complications | Not applicable | Completed | Aswan University Hospital | 450 | 2018-11-01 | 2020-08-05 |
| Oral and Topical Tranexamic Acid for the Treatment of Melasma Oral Tranexamic Acid, 5% topical tranexamic acid, 4% hydroquinone - Melasma, Chloasma | Phase 3 | Unknown | Centro Dermatológico Dr. Ladislao de la Pascua | 120 | 2018-08-01 | 2018-07-16 |
| Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum intravenous tranexamic acid, Topical tranexamic acid, Normal saline - Cesarean Section Complications | Not applicable | Completed | Aswan University Hospital | 80 | 2018-01-01 | 2021-08-09 |
| Reducing Blood Loss During Cesarean Myomectomy With Tranexamic Acid IV tranexamic acid - Cesarean Section Complications | Not applicable | Completed | Aswan University Hospital | 120 | 2018-01-01 | 2020-03-20 |
| Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty Topical tranexamic acid, Floseal®, rivaroxaban (10mg) - Osteoarthritis, Knee | Phase 4 | Completed | Chang Gung Memorial Hospital | 70 | 2017-09-12 | 2021-08-10 |
| Topical Tranexamic Acid and Floseal® in Total Knee Arthroplasty Topical tranexamic acid, Floseal®, Enoxaparin - Osteoarthritis, Knee | Phase 4 | Unknown | Chang Gung Memorial Hospital | 90 | 2016-09-01 | 2016-08-12 |
| Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement Intravenous tranexamic acid, Topical tranexamic acid, Intravenous saline - Osteoarthritis, Knee | Phase 4 | Completed | Hospital for Special Surgery, New York | 76 | 2015-11-19 | 2020-03-25 |
| Topical Tranexamic Acid in Caesarean Section Topical tranexamic acid, Normal saline 0.9% - Postpartum Haemorrhage | Phase 3 | Unknown | Dr Meng-Li Lee | 84 | 2015-08-01 | 2016-03-16 |
| Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical Topical Tranexamic Acid, Intravenous Tranexamic Acid - Osteoarthritis | Phase 4 | Completed | Hospital for Special Surgery, New York | 640 | 2013-05-01 | 2019-11-27 |
| Tranexamic Acid in Cyanotic Heart Defects Normal saline at induction, Normal saline infusion, Intravenous tranexamic acid - Postoperative Hemorrhage | Phase 2 | Completed | Assiut University | 120 | 2009-01-01 | 2018-01-31 |
Osteoarthritis, Knee (3) · Postpartum Hemorrhage (3) · Placenta Previa (2) · Acute Pain (1) · Hemorrhage (1) · Joint Diseases (1) · Melanosis (1) · Osteoarthritis (1) · Placenta Accreta (1) · Postoperative Hemorrhage (1) · Wrist Fractures (1)
Aswan University Hospital (7) · Chang Gung Memorial Hospital (2) · Hospital for Special Surgery, New York (2) · Assiut University (1) · Cairo University (1) · Centro Dermatológico Dr. Ladislao de la Pascua (1) · Dr Meng-Li Lee (1) · Massachusetts General Hospital (1) · Sohag University (1) · University Health Network, Toronto (1)
Egypt (7) · United States (3) · Taiwan (2) · Canada (1) · Malaysia (1) · Mexico (1)
David Mayman, MD (1) · Jun-Wen Wang (1) · Jun-Wen Wang, MD (1) · Kethy Jules-Elysee, MD (1) · Meng-Li Lee, FANZCA (1)