127 completed, 4 terminated, 3 unknown, 3 withdrawn. 52 Phase 3, 38 Phase 4, 20 Phase 2, 13 Phase 1, 3 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Efficacy of Once-daily LAMA/LABA Combinations Versus Tiotropium on Constant-work-rate Cycle Endurance in COPD Tiotropium, Olodaterol, Umeclidinium - COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Suspended | Medical University of Bialystok | 100 | 2024-03-11 | 2026-10-02 |
| Effect of Tiotropium on Eye Findings in the Treatment of Chronic Obstructive Pulmonary Disease Tiotropium - Chronic Obstructive Pulmonary Disease, Glaucoma, Angle-Closure | Completed | Giresun University | 108 | 2023-10-23 | 2024-07-29 | |
| Phase 4 COPD and Suboptimal Inspiratory Flow Rate Revefenacin, Tiotropium, Revefenacin Placebo - Chronic Obstructive Pulmonary Disease | Phase 4 | Completed | Theravance Biopharma | 404 | 2022-01-07 | 2024-12-20 |
| Effects of Acute Long-acting Bronchodilation on Oxygenation and Peripheral Ventilation in COPD LABA, LAMA - Pulmonary Disease, Chronic Obstructive | Phase 3 | Completed | Erasme University Hospital | 30 | 2021-06-15 | 2023-07-03 |
| Exacerbation Risk in Asthma tiotropium, long-acting β2-agonists (LABA), inhaled corticosteroids (ICS) - Asthma | Completed | Boehringer Ingelheim | 1899 | 2021-05-14 | 2024-04-01 | |
| Replication of the POET-COPD Trial in Healthcare Claims Data Salmeterol, Tiotropium - Chronic Obstructive Pulmonary Disease | Completed | Brigham and Women's Hospital | 8716 | 2020-09-22 | 2023-07-27 | |
| Replication of the INSPIRE Trial in Healthcare Claims Data Tiotropium, salmeterol-fluticasone - Chronic Obstructive Pulmonary Disease | Completed | Brigham and Women's Hospital | 98278 | 2020-09-22 | 2023-07-27 | |
| Early Intervention Efficacy in COPD Tiotropium/Olodaterol, Tiotropium - Pulmonary Disease, Chronic Obstructive | Completed | Boehringer Ingelheim | 6788 | 2020-03-27 | 2022-06-14 | |
| Effect of Charcoal on Gastrointestinal Absorption of Tiotropium Tiotropium - Healthy Volunteer Study | Phase 1 | Completed | Orion Corporation, Orion Pharma | 20 | 2019-05-27 | 2019-09-23 |
| Effectiveness of Fluticasone Furoate/ Umeclidinium/ Vilanterol (FF/UMEC/VI) Using the Connected Inhaler System (CIS) as Compared With Fluticasone Proprionate/ Salmeterol (FP/SAL) Plus Tiotropium (TIO) in Inadequately Controlled Asthma FF/UMEC/VI, FP/SAL, Tiotropium - Asthma | Phase 3 | Withdrawn | GlaxoSmithKline | 2019-01-18 | 2019-03-25 | |
| A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD) budesonide/formoterol, albuterol/salbutamol, FF/UMEC/VI - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | GlaxoSmithKline | 732 | 2018-06-25 | 2020-10-28 |
| A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD) budesonide/formoterol, albuterol/salbutamol, FF/UMEC/VI - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | GlaxoSmithKline | 729 | 2018-06-25 | 2020-10-28 |
| A Comparative Study Between Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy Versus Tiotropium Monotherapy in Subjects With Chronic Obstructive Pulmonary Disease (COPD) FF/UMEC/VI, Tiotropium, Albuterol/salbutamol - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | GlaxoSmithKline | 800 | 2018-03-29 | 2021-07-15 |
| Personalized Treatment Algorithms for Difficult-to-treat Asthma Cholecalciferol, antihistamine, Azithromycin - Asthma in Children | Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 21 | 2018-03-16 | 2021-08-20 |
| Efficiency of Twice Daily Formoterol Versus Once Daily Tiotropium in Patients With GOLD A/B COPD Tiotropium, Formoterol - Chronic Obstructive Pulmonary Disease | Not applicable | Unknown | Huashan Hospital | 120 | 2017-11-01 | 2017-10-19 |
| The ENERGITO® 2 Study Compares 2 Inhaled Medicines for Chronic Obstructive Pulmonary Disease (COPD). One Medicine is a Combination of Tiotropium and Olodaterol (Stiolto®) Taken Using the Respimat® Inhaler and the Other Medicine is a Combination of Fluticasone and Salmeterol Taken Using the Diskus Tiotropium, Olodaterol, Fluticasone propionate - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | Boehringer Ingelheim | 302 | 2017-08-14 | 2020-04-16 |
| Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two Inhalers Tiotropium - Healthy | Phase 1 | Completed | Kindeva Drug Delivery | 40 | 2017-07-13 | 2025-12-04 |
| Cardiovascular Function in COPD Patients Tiotropium, Olodaterol, Fluticasone propionate - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | Boehringer Ingelheim | 76 | 2017-03-29 | 2019-08-16 |
| Revefenacin Peak Inspiratory Flow Rate (PIFR) Study in COPD Revefenacin, Spiriva Handihaler®, Placebo for Revefenacin - Chronic Obstructive Pulmonary Disease, COPD, Low Peak Inspiratory Flow Rate (PIFR) | Phase 3 | Completed | Mylan Inc. | 207 | 2017-03-27 | 2022-02-24 |
| Bioavailability of Tiotropium + Olodaterol Fixed-dose Combination (5 μg/ 5 μg) in Chinese COPD Patients Tiotropium, Olodaterol - Pulmonary Disease, Chronic Obstructive | Phase 1 | Completed | Boehringer Ingelheim | 12 | 2017-02-24 | 2019-03-29 |
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Pulmonary Disease, Chronic Obstructive (121) · Asthma (7) · Emphysema (5) · Respiratory Aspiration (5) · Bronchitis, Chronic (4) · Dyspnea (2) · Motor Activity (2) · Bronchitis (1) · Eye Manifestations (1) · Glaucoma (1) · Glaucoma, Angle-Closure (1) · Inflammation (1) · Quadriplegia (1) · Sleep Initiation and Maintenance Disorders (1) · Smoking (1)
Boehringer Ingelheim (56) · Novartis Pharmaceuticals (20) · GlaxoSmithKline (14) · AstraZeneca (4) · Brigham and Women's Hospital (3) · Novartis (3) · Solventum US LLC (3) · Chiesi Farmaceutici S.p.A. (2) · Mylan Inc. (2) · National Institute of Respiratory Diseases, Mexico (2) · Sumitomo Pharma America, Inc. (2) · University of Dundee (2) · Centre Hospitalier Universitaire de Besancon (1) · Children's Hospital Medical Center, Cincinnati (1) · Erasme University Hospital (1)
United States (53) · Germany (46) · Canada (27) · United Kingdom (26) · Netherlands (22) · Belgium (19) · France (18) · Hungary (17) · Denmark (16) · Poland (16) · Italy (15) · Russia (15) · Argentina (14) · South Africa (14) · Spain (14)
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