4 completed, 1 recruiting, 1 terminated, 1 withdrawn. 7 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 4, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 4 | Completed 2, Terminated 1, Withdrawn 1 |
Follow Thioguanine: new trials by email Literature Review of Thioguanine trials Research Report on Thioguanine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Thiopurine Enhanced Mutations for PD-1/Ligand-1 Efficacy Atezolizumab, 6-mercaptopurine, 6-thioguanine - Solid Tumor, Adult, Metastatic Cancer | Phase 1 / Phase 2 | Completed | Kristoffer Rohrberg | 18 | 2022-09-01 | 2026-01-14 |
| Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia Ruxolitinib, Cyclophosphamide, Cytarabine - Acute Lymphoblastic Leukemia, ALL, Childhood | Phase 1 | Recruiting | University of Chicago | 15 | 2019-05-28 | 2026-06-29 |
| Thiopurine EnhAnced Maintenance Therapy Thioguanine (oral) - Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma | Phase 1 / Phase 2 | Completed | Kjeld Schmiegelow | 30 | 2016-10-01 | 2020-04-15 |
| Study of 6-Thioguanine in Combination With 6-Mercaptopurine During Maintenance Therapy of Childhood Lymphoma 6-thioguanine - Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | Withdrawn | Kjeld Schmiegelow | 2014-07-01 | 2016-10-07 | |
| Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011) Cyclophosphamide, Cytarabine, Daunorubicin Hydrochloride - Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia | Phase 1 | Completed | Children's Oncology Group | 104 | 2009-02-23 | 2021-04-27 |
| ABT-751 With Chemotherapy for Relapsed Pediatric ALL ABT-751, Dexamethasone, PEG-asparaginase - Recurrent Pediatric ALL, Relapsed Pediatric ALL | Phase 1 / Phase 2 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 9 | 2006-05-22 | 2021-03-17 |
| Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia filgrastim, asparaginase, cytarabine - Leukemia | Phase 1 | Completed | Children's Oncology Group | 35 | 1999-10-01 | 2014-07-28 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (4) · Burkitt Lymphoma (1) · Leukemia (1) · Leukemia, Monocytic, Acute (1) · Lymphoma, Non-Hodgkin (1) · Neoplasm Metastasis (1) · Neoplasms (1) · Recurrence (1)
Children's Oncology Group (2) · Kjeld Schmiegelow (2) · Kristoffer Rohrberg (1) · Therapeutic Advances in Childhood Leukemia Consortium (1) · University of Chicago (1)
United States (4) · Denmark (3) · Canada (2) · Australia (1)
Craig A. Hurwitz, MD (1) · Kjeld Schmiegelow, M.D. (1) · Kjeld Schmiegelow, Professor (1) · Kristoffer S Rohrberg, MD PhD (1) · Paul S Gaynon, MD (1) · Wendy Stock, MD (1) · ZoAnn E Dreyer (1)
U10CA098413 (1), U10CA098543 (1), U10CA180886 (1), U10CA180899 (1)