8 completed, 1 recruiting, 1 terminated. 4 Phase 1, 2 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow tedizolid: new trials by email Literature Review of tedizolid trials Research Report on tedizolid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditis Cefaclor, Ciprofloxacin Tablets, Ciprofloxacin Injection - Endocarditis Infective | Phase 4 | Recruiting | Fundacion Clinic per a la Recerca Biomédica | 360 | 2022-08-17 | 2026-07-07 |
| Tedizolid Suppressive Antimicrobial Therapy in a Reference Center patients having had a BJI/PJI treated with tedizolid as a suppressive antibiotic therapy - Bone and Joint Infection | Completed | Hospices Civils de Lyon | 17 | 2021-02-01 | 2021-06-21 | |
| Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections (OTTER) Tedizolid - Bone and Joint Infection | Phase 2 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 44 | 2017-02-06 | 2023-12-13 |
| Sivextro in Acute Bacterial Skin and Skin Structure Infection (ABSSSI) in Hospitalized Patients. A Global Observational Study Tedizolid (Sivextro, BAY1192631), Linezolid - Skin Disease, Infectious | Terminated | Bayer | 108 | 2016-12-17 | 2019-10-02 | |
| Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis Tedizolid, Microdialysis Catheter Insertion - Diabetes, Wound Infection | Phase 1 | Completed | Hartford Hospital | 18 | 2016-02-23 | 2019-01-15 |
| Efficacy and Safety of Intravenous to Oral 6-Day Tedizolid Phosphate vs. Intravenous to Oral 10-Day Linezolid in Patients With Acute Bacterial Skin and Skin Structure Infection (ABSSSI) Tedizolid (BAY119-2631), Placebo Tedizolid (BAY119-2631), Linezolid - Bacterial Infections | Phase 3 | Completed | Bayer | 598 | 2014-03-04 | 2017-06-07 |
| A Phase 2 Safety and Exploratory Skin Lesion Measurement of TR-701 FA Study TR701 FA - Major Cutaneous Abscess, Cellulitis | Phase 2 | Completed | Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 200 | 2012-02-15 | 2018-08-29 |
| A Thorough QT Study of TR-701free Acid (FA) in Healthy Subjects TR-701 FA 1200 mg, Moxifloxacin 400 mg, TR-701 FA 200 mg plus Placebo - Healthy Volunteer | Phase 1 | Completed | Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 48 | 2011-11-28 | 2018-12-05 |
| A Pharmacokinetics and Safety Study in Subjects With Renal Impairment TR-701 FA single infusion, TR-701 FA - Renal Impairment | Phase 1 | Completed | Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 24 | 2011-10-01 | 2016-05-03 |
| Microdialysis and Pharmacokinetic Study of TR-701 TR-700 (active moiety), TR-701 (pro-drug) - Healthy | Phase 1 | Completed | Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 15 | 2008-04-04 | 2019-11-15 |
Cellulitis (2) · Erysipelas (2) · Wound Infection (2) · Abscess (1) · Bacterial Infections (1) · Diabetes Mellitus (1) · Endocarditis (1) · Osteomyelitis (1) · Renal Insufficiency (1) · Skin Diseases, Infectious (1)
Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Bayer (2) · Fundacion Clinic per a la Recerca Biomédica (1) · Hartford Hospital (1) · Hospices Civils de Lyon (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1)
United States (7) · China (1) · France (1) · Mexico (1) · Philippines (1) · Russia (1) · Singapore (1) · Spain (1) · Taiwan (1)
Philippe Prokocimer, MD (2) · David P Nicolau, PharmD (1) · Harmut Derendorf, PhD (1) · Loren G Miller, MD MPH (1) · Philippe G Prokocimer, MD (1)
PMID 22584101, PMID 25136024, PMID 27530088, PMID 30988146, PMID 40024946