18 completed, 5 unknown, 3 active not recruiting, 3 recruiting. 10 Phase 2, 9 Phase 3, 7 Phase 4, 5 Phase 1, 2 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sequential PD-1 Antibody and Pegylated Interferon Therapy for Nucleos(t)Ide Analogue-suppressed Chronic Hepatitis B Sintilimab, Pegylated Interferon-α 2b, Nucleos(t)ide Analogues - Chronic Hepatitis B | Not applicable | Not yet recruiting | Beijing 302 Hospital | 60 | 2026-09-01 | 2026-09-09 |
| Efficacy and Safety of Pegylated Interferon Alpha-2β in Patients With Hepatitis B-related Hepatocellular Carcinoma After Radical Resection Peginterferon alfa-2b, TDF, TAF - Hepatocellular Carcinoma, HEPATITIS B CHRONIC | Early Phase 1 | Not yet recruiting | Ningbo No.2 Hospital | 156 | 2026-03-31 | 2026-04-28 |
| A Small Sample Prospective Clinical Study of Azvudine Tablets to Promote Clinical Cure in Patients With Chronic Hepatitis B AZVUDINE, TAF, IFNα-2a - Chronic Hepatitis B, Azvudine | Phase 3 | Recruiting | Zhigang Ren | 120 | 2025-09-01 | 2025-12-29 |
| Comparison of TAF and TDF in Preventing Mother-to-Child Transmission of HBV in Pregnancies With High Viral Loads TAF group, TDF group - Hepatitis B | Not applicable | Recruiting | Guangzhou 8th People's Hospital | 210 | 2025-05-03 | 2025-05-07 |
| TAF in Early/Middle Pregnancy With CHB TAF, TDF - Hepatitis B Infection, Pregnant Women | Phase 4 | Enrolling by invitation | The Third Affiliated Hospital of Guangzhou Medical University | 816 | 2025-03-31 | 2026-06-25 |
| TAF vs TDF During the Pregancy TAF - Hepatitis B Virus Infection; Pregnant Women | Phase 4 | Enrolling by invitation | The Third Affiliated Hospital of Guangzhou Medical University | 210 | 2024-12-27 | 2026-10-16 |
| A Study to Assess Efficacy and Safety of HH-003 Injection in Subjects With Chronic Hepatitis Delta Virus Infection HH-003(20mg/kg), HH-003(10mg/kg), TAF - Chronic Hepatitis Delta Virus Infection | Phase 2 | Completed | Huahui Health | 101 | 2023-06-16 | 2026-10-22 |
| PK of TAF and TDF for PrEP in Pregnant and Postpartum Women Tenofovir alafenamide, Tenofovir Disoproxil Fumarate - Hiv | Phase 3 | Completed | University of California, Los Angeles | 39 | 2022-06-13 | 2024-09-03 |
| A Study of JNJ-73763989, JNJ-64300535, and Nucleos(t)Ide Analogs in Virologically Suppressed, Hepatitis B e Antigen (HBeAg)- Negative Participants With Chronic Hepatitis B Virus Infection JNJ-73763989, JNJ-64300535, ETV monohydrate - Hepatitis B, Chronic | Phase 1 | Completed | Janssen Research & Development, LLC | 24 | 2021-12-06 | 2025-05-26 |
| A Study of JNJ-73763989, Pegylated Interferon Alpha-2a and Nucleos(t)Ide Analogs in Participants With Chronic Hepatitis B Virus Infection JNJ-73763989, PegIFN-alpha-2a, Tenofovir disoproxil - Hepatitis B, Chronic | Phase 2 | Terminated | Janssen Research & Development, LLC | 1 | 2021-11-03 | 2024-03-06 |
| The Efficacy of Prophylactic TAF for HBsAg-positive Patients Receiving bDMARDs Tenofovir alafenamide - HBV, Inflammatory Arthritis | Phase 4 | Unknown | Taipei Veterans General Hospital, Taiwan | 108 | 2021-08-15 | 2021-08-12 |
| Study to Evaluate the Safety and Efficacy of Selgantolimod (SLGN)-Containing Combination Therapies for the Treatment of Chronic Hepatitis B (CHB) Tenofovir Alafenamide, VIR-2218, Nivolumab - Chronic Hepatitis B | Phase 2 | Completed | Gilead Sciences | 103 | 2021-08-14 | 2025-07-24 |
| Tenofovir Alafenamide Switching Therapy in Kidney or Liver Transplant Recipients With Chronic HBV Infection Tenofovir Alafenamide 25 MG - Safety Issues, Chronic Hepatitis B | Phase 4 | Active not recruiting | Taichung Veterans General Hospital | 52 | 2021-06-22 | 2026-05-04 |
| Study of Tenofovir Alafenamide in HBV-Infected Pregnant Women Tenofovir Alafenamide Tablets - Chronic Hepatitis b, Tenofovir Alafenamide Fumarate | Phase 4 | Recruiting | First People's Hospital of Hangzhou | 50 | 2021-05-06 | 2025-09-08 |
| GLS4/RTV and TAF Drug-drug Interaction GLS4, RTV, TAF - Chronic Hepatitis B | Phase 1 | Completed | Sunshine Lake Pharma Co., Ltd. | 28 | 2021-01-10 | 2022-05-26 |
| Study to Evaluate the Safety and Efficacy of Lenacapavir (GS-6207) in Combination With Other Antiretroviral Agents in People Living With HIV Oral Lenacapavir, F/TAF, Subcutaneous Lenacapavir - HIV-1-infection | Phase 2 | Completed | Gilead Sciences | 183 | 2019-11-22 | 2024-10-02 |
| Effect and Safety of Propofol Fumarate for Mother-to-child Blocking of Hepatitis B TAF, TDF - Chronic Hepatitis B Infection, High Viral Load | Unknown | Beijing Ditan Hospital | 440 | 2019-08-01 | 2019-10-22 | |
| Study to Evaluate Safety, Pharmacokinetics, and Antiviral Activity of Lenacapavir Administered Subcutaneously in Human Immunodeficiency Virus (HIV) -1 Infected Adults Lenacapavir, Placebo, B/F/TAF - HIV-1 Infection | Phase 1 | Completed | Gilead Sciences | 53 | 2018-11-26 | 2021-04-09 |
| Switching From Tenofovir Disoproxi Fumarate to Tenofovir Alafenamide in Chronic Hepatitis B Patients With Antiviral Resistance Tenofovir disoproxil fumarate 300mg, Tenofovir Alafenamide 25 mg - Hepatitis B, Antiviral Drug Adverse Reaction | Unknown | Yonsei University | 300 | 2018-09-01 | 2018-06-21 | |
| Study to Evaluate the Safety, Tolerability, and Antiviral Activity of Selgantolimod (Formerly GS-9688) in Viremic Adult Participants With Chronic Hepatitis B (CHB) Who Are Not Currently on Treatment Placebo, Selgantolimod, TAF - Chronic Hepatitis B | Phase 2 | Completed | Gilead Sciences | 67 | 2018-08-28 | 2022-05-10 |
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Hepatitis B, Chronic (16) · Hepatitis B (8) · Hepatitis (5) · Acquired Immunodeficiency Syndrome (3) · Arthritis (1) · Carcinoma, Hepatocellular (1) · Drug-Related Side Effects and Adverse Reactions (1) · HIV Infections (1) · Patient Compliance (1) · Renal Insufficiency, Chronic (1)
Gilead Sciences (16) · Janssen Research & Development, LLC (2) · The Third Affiliated Hospital of Guangzhou Medical University (2) · Asian Pacific Liver Center at Coalition of Inclusive Medicine (1) · Beijing 302 Hospital (1) · Beijing Ditan Hospital (1) · Erasmus Medical Center (1) · First People's Hospital of Hangzhou (1) · Guangzhou 8th People's Hospital (1) · Huahui Health (1) · Ningbo No.2 Hospital (1) · Sunshine Lake Pharma Co., Ltd. (1) · Taichung Veterans General Hospital (1) · Taipei Veterans General Hospital, Taiwan (1) · Thomas Jefferson University (1)
China (12) · United States (12) · Taiwan (9) · South Korea (8) · Hong Kong (7) · New Zealand (7) · Canada (6) · United Kingdom (6) · Italy (5) · Spain (5) · Poland (4) · Russia (4) · Australia (3) · France (3) · India (3)
Angela DM Kashuba, PharmD (1) · Bart Rijnders, MD PhD (1) · Junliang Fu (1) · Landon Myer, MD (1) · Panpan Zhai (1) · Siying Li, MD (1) · Teng-Yu Lee, MD, PhD (1) · Wei Yi, Doctor (1) · Yao Xie, Doctor (1) · Zhiyuan Ma, PhD (1)
PMID 37771546, PMID 28404091, PMID 28404092, PMID 29756595, PMID 29933096, PMID 30038044, PMID 32087795, PMID 37561058, PMID 39327857, PMID 27230467, PMID 28369415, PMID 28427875, PMID 29405329, PMID 29696665, PMID 30576085, PMID 31199513, PMID 31271737, PMID 31777965, PMID 32282538, PMID 32304611, PMID 32612233, PMID 33217163, PMID 33404182, PMID 34358495, PMID 38901444, PMID 40744841, PMID 41056006
2016 (3), 2014 (1), 2023 (1)