107 completed, 13 terminated, 6 unknown, 3 recruiting. 51 Phase 3, 19 Phase 4, 17 Phase 2, 14 Phase 1, 5 Not applicable.
Follow Somatropin: new trials by email Literature Review of Somatropin trials Research Report on Somatropin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Learn How Different Injector Pens Affect the Study Medicine Called Genotropin (Somatropin) Delivery and Taken up Into the Blood in Healthy Adults Marketed Genotropin Pen 12, New Genotropin Injector Pen, Genotropin 4mg - Healthy | Phase 1 | Completed | Pfizer | 27 | 2026-04-22 | 2026-08-10 |
| Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) Somatropin, Placebo - Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury | Phase 3 | Recruiting | VA Office of Research and Development | 172 | 2025-01-13 | 2026-10-13 |
| Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT) Recombinant human growth hormone - Gulf War Syndrome, Adult Growth Hormone Deficiency | Phase 2 | Recruiting | Baylor College of Medicine | 20 | 2024-03-11 | 2026-05-08 |
| Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children Somatropin - Growth Disorders, Growth Failure | Phase 3 | Recruiting | Northwell Health | 50 | 2023-12-10 | 2026-10-21 |
| The Effect of Myo-inositol, Somatropin, and DHEA on Poor Ovarian Responders myo-inositol, Somatropin, Dehydroepiandrosterone - Poor Responders | Phase 2 / Phase 3 | Unknown | Beni-Suef University | 300 | 2023-07-30 | 2023-07-18 |
| A Trial to Investigate Different Doses of Lonapegsomatropin Compared to Somatropin in Individuals With Turner Syndrome Lonapegsomatropin, Somatropin - Turner Syndrome | Phase 2 | Active not recruiting | Ascendis Pharma Endocrinology Division A/S | 48 | 2023-02-15 | 2026-05-13 |
| Growth Hormone in a Patient With a Dominant-Negative GHR Mutation Somatropin - Growth Disorders | Phase 2 | Active not recruiting | Children's National Research Institute | 1 | 2022-08-26 | 2025-07-02 |
| French Registry of Children Treated With Norditropin® for Short Stature Associated With Noonan Syndrome Norditropin - Noonan Syndrome | Enrolling by invitation | Novo Nordisk A/S | 221 | 2022-03-16 | 2026-10-08 | |
| A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency Lonapegsomatropin, Placebo, Somatropin - Growth Hormone Deficiency, Endocrine System Diseases | Phase 3 | Completed | Ascendis Pharma Endocrinology Division A/S | 264 | 2020-12-03 | 2026-07-07 |
| A Study to Evaluate the Efficacy of Somatropin in the Treatment of Patellar Tendinopathy Somatropin, Bacteriostatic saline, Progressive exercise program - Tendinopathy | Phase 2 | Withdrawn | Hospital for Special Surgery, New York | 2020-05-01 | 2022-03-31 | |
| 6x3 Crossover, Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy Volunteers Somatropin - Bioavailability, Safety and Tolerability Among Different Eutropin Formulations in Healthy Volunteers | Phase 1 | Completed | LG Chem | 24 | 2019-09-10 | 2020-03-24 |
| Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy Somatropin - Traumatic Brain Injury, Fatigue | Phase 3 | Completed | The University of Texas Medical Branch, Galveston | 72 | 2018-08-06 | 2025-03-05 |
| Post Marketing Surveillance on Long-term Use With Norditropin® (Short Stature Due to Noonan Syndrome) Somatropin - Genetic Disorder, Noonan Syndrome | Completed | Novo Nordisk A/S | 71 | 2018-02-26 | 2022-11-14 | |
| Growth Hormone Treatment in Patients With Aggrecan (ACAN) Deficiency Norditropin - Short Stature | Phase 1 / Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 22 | 2018-02-01 | 2024-07-30 |
| Study of Testosterone and rHGH in FSHD Testosterone Enanthate, Somatropin - Facioscapulohumeral Muscular Dystrophy | Phase 1 | Completed | University of Rochester | 20 | 2017-12-18 | 2023-05-16 |
| Augmenting Growth Hormone to Ameliorate Nonalcoholic Fatty Liver Disease in Adolescents somatropin - NAFLD | Early Phase 1 | Completed | Massachusetts General Hospital | 24 | 2017-05-03 | 2022-09-07 |
| Safety and Efficacy Phase 3 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children MOD-4023, Somatropin - Pediatric Growth Hormone Deficiency | Phase 3 | Completed | OPKO Health, Inc. | 224 | 2016-12-01 | 2025-07-20 |
| Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj. Somatropin - Short Stature, Idiopathic, Infant, Small for Gestational Age | Phase 4 | Completed | LG Life Sciences | 116 | 2016-08-11 | 2019-01-03 |
| Substrate Metabolism, Growth Hormone Signaling (GH), and Insulin Sensitivity During GH and Ketone Bodies Infusion Somatropin, Ketone bodies - Healthy | Not applicable | Completed | University of Aarhus | 10 | 2016-01-01 | 2017-11-01 |
| Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients Somatropin, 0.09% Saline Solution - Burns, Growth Hormone Treatment | Phase 2 / Phase 3 | Completed | The University of Texas Medical Branch, Galveston | 13 | 2015-11-01 | 2023-02-13 |
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Dwarfism, Pituitary (43) · Growth Disorders (17) · Genetic Diseases, Inborn (15) · Turner Syndrome (14) · Noonan Syndrome (6) · Endocrine System Diseases (5) · Kidney Failure, Chronic (5) · Renal Insufficiency, Chronic (5) · Dwarfism (4) · Brain Injuries, Traumatic (3) · Achondroplasia (2) · Brain Concussion (2) · Failure to Thrive (2) · HIV Infections (2) · Hypopituitarism (2)
Novo Nordisk A/S (53) · Pfizer (13) · Merck KGaA, Darmstadt, Germany (12) · Eli Lilly and Company (9) · Ferring Pharmaceuticals (3) · Genentech, Inc. (3) · The University of Texas Medical Branch, Galveston (3) · Ascendis Pharma Endocrinology Division A/S (2) · Massachusetts General Hospital (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · OPKO Health, Inc. (2) · Altus Pharmaceuticals (1) · Ascendis Pharma A/S (1) · Azidus Brasil (1) · Baylor College of Medicine (1)
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PMID 29029101, PMID 18395480, PMID 22508317, PMID 22788856, PMID 23658497, PMID 31305924, PMID 31972476, PMID 33571362, PMID 33709288, PMID 33864240, PMID 36380045, PMID 36947589, PMID 40919719, PMID 41285480, PMID 10487666, PMID 10518081, PMID 10599727, PMID 10599729, PMID 11061539, PMID 11155088, PMID 11207640, PMID 12466334, PMID 12519875, PMID 12629094, PMID 12915640, PMID 14671164, PMID 15784709, PMID 15900109, PMID 16203673, PMID 16757526, PMID 16772718, PMID 17062774, PMID 17322494, PMID 17356043, PMID 17536000, PMID 17554147, PMID 17634080, PMID 18941347, PMID 18945992, PMID 19039085, PMID 19479077, PMID 20522533, PMID 20631018, PMID 21619701, PMID 21724838, PMID 21963127, PMID 22156542, PMID 22465047, PMID 22508151, PMID 22682146
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