84 completed, 17 terminated, 17 unknown, 15 recruiting. 78 Not applicable, 40 Phase 3, 28 Phase 2, 8 Phase 1, 4 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction PADN, Sham procedure, GDMT - Heart Failure With Preserved Ejection Fraction | Not applicable | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 310 | 2026-12-30 | 2026-05-27 |
| A Study to Learn About the Safety and Effects of Salanersen (BIIB115) When Given to Babies With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Onasemnogene Abeparvovec Salanersen, Sham Procedure - Muscular Atrophy, Spinal | Phase 3 | Recruiting | Biogen | 42 | 2026-10-31 | 2026-10-15 |
| Renal Artery Denervation Assessment Without Antihypertensive Medication Regimen (RADAR) Dehydrated Alcohol Injection, USP, Sham procedure - Hypertension, Hypertension,Essential | Phase 3 | Not yet recruiting | Ablative Solutions, Inc. | 202 | 2026-10-01 | 2026-08-20 |
| BEACON - Phase III Clinical Study of Rugonersen in Angelman Syndrome. rugonersen, Sham procedure - Angelman Syndrome | Phase 3 | Recruiting | OHB Pediatrics Ltd. | 165 | 2026-06-23 | 2026-10-20 |
| SII Levels Following PENG Block in Pediatric Hip Surgery Ropivacaine 0.2% Injectable Solution, 0.9%NaCl - Hip Dysplasia | Not applicable | Not yet recruiting | Poznan University of Medical Sciences | 100 | 2026-06-01 | 2026-05-26 |
| The Effect of Spinal Manipulation on Heart Rate Variability in Children With Cerebral Palsy. Spinal manipulation, Sham Procedure - Cerebral Palsy (CP) | Not applicable | Recruiting | International Clinic of Rehabilitation, Ukraine | 20 | 2026-05-01 | 2026-05-29 |
| Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant Gen 2 Travoprost Intracameral Implant, Timolol eye drops 0.5%, Sham Procedure - Glaucoma | Phase 3 | Recruiting | Glaukos Corporation | 510 | 2026-02-17 | 2026-03-30 |
| External Oblique Intercostal Plane Block for Liver Transplantation Recipient External Oblique Intercostal Plane Block, Sham Procedure - Liver Transplantation, Recipients of Liver Transplant | Not applicable | Completed | Istinye University | 64 | 2025-12-22 | 2026-06-25 |
| Clinical Study of the Pulsed Electric Field Ablation System in Chronic Obstructive Pulmonary Disease Pulse electric field ablation system, Sham Procedure - Chronic Bronchitis, COPD (Chronic Obstructive Pulmonary Disease) | Not applicable | Recruiting | Suzhou Hengruihongyuan Medical Technology Co. LTD | 210 | 2025-09-01 | 2025-09-02 |
| EuroNetrod HTN OFF-Med Study of Renal Denervation With NetrodTM Six-electrode Radiofrequency RDN System Netrod™ six-electrode radiofrequency renal denervation system, Sham Procedure - Uncontrolled Hypertension | Not applicable | Withdrawn | Shanghai Golden Leaf MedTec Co. Ltd | 2025-08-30 | 2025-07-31 | |
| Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention in Patients With Diabetic Foot Ulcers and Lower Extremity Arterial Occlusion Cold atmospheric plasma (CAP), Sham Procedure, Successful infrapopliteal angioplasty - Diabetic Foot Ulcers (DFU), Lower Extremity Arterial Occlusion | Not applicable | Recruiting | Shenyang Medical College | 86 | 2025-07-22 | 2026-01-30 |
| Serratus Posterior Superior Intercostal Plane Block in Cardiac Implantable Electronic Device Implantation SPSIP Block, Sham procedure - Pain, Postoperative | Not applicable | Completed | Gozde Altun | 60 | 2025-06-30 | 2026-06-11 |
| Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral Implant Gen 2 Travoprost Intracameral Implant, Timolol eye drops 0.5%, Sham Procedure - Glaucoma | Phase 2 | Recruiting | Glaukos Corporation | 110 | 2025-06-12 | 2026-09-17 |
| Erector Spinae Plane Block for Acute Back Pain in the Emergency Department Erector Spinae Plane Block, Sham Procedure - Low Back Pain | Not applicable | Recruiting | Rush University Medical Center | 62 | 2025-02-03 | 2026-03-12 |
| Trans-nasal Sphenopalatine Ganglion Block for Prevention of Emergence Agitation Following Functional Endoscopic Sinus Surgery Bilateral Trans-nasal Sphenopalatine Ganglion Block, Sham Trans-nasal Injection - Chronic Rhinosinusitis (CRS), Emergence Agitation | Not applicable | Completed | Mansoura University | 100 | 2025-01-05 | 2026-06-12 |
| ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS) ION440, Sham procedure - Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome | Phase 1 / Phase 2 | Recruiting | Ionis Pharmaceuticals, Inc. | 48 | 2024-10-21 | 2026-10-08 |
| A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD) JNJ-81201887, Sham Procedure - Geographic Atrophy, Macular Degeneration | Phase 2 / Phase 3 | Recruiting | Janssen Research & Development, LLC | 274 | 2024-09-19 | 2026-09-30 |
| Trial to Evaluate Efficacy+Safety of Revita DMR Treatment Paradigm 1 and Retreatment in Type 2 Diabetes Patients Revita® DMR Treatment, Sham procedure - Diabetes Mellitus, Type 2 | Not applicable | Active not recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 18 | 2024-08-09 | 2026-08-06 |
| Safety and Effectiveness of Endoscopic Intestinal Re-Cellularization Therapy in Individuals With Type II Diabetes Endogenex Treatment, Sham Procedure - Type 2 Diabetes Mellitus, Type2diabetes | Not applicable | Active not recruiting | Endogenex, Inc. | 350 | 2024-05-01 | 2026-08-05 |
| A Study of the Efficacy and Safety of KUS121 in Participants With Acute Non-Arteritic Central Retinal Artery Occlusion (CRAO) KUS121 high dose, KUS121 low dose, Sham procedure - Central Retinal Artery Occlusion | Phase 2 | Completed | Kyoto Drug Discovery and Development Co., Ltd. | 17 | 2024-04-16 | 2026-02-18 |
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Hypertension (10) · Macular Degeneration (9) · Eye Diseases (6) · Macular Edema (6) · Retinal Diseases (6) · Vision Disorders (6) · Diabetes Mellitus, Type 2 (5) · Gastroesophageal Reflux (5) · Geographic Atrophy (5) · Glaucoma, Open-Angle (5) · Obesity (5) · Retinal Degeneration (5) · Vascular Diseases (5) · Vision, Low (5) · Essential Hypertension (4)
Hoffmann-La Roche (13) · Allergan (5) · Kodiak Sciences Inc (5) · Biogen (4) · Apellis Pharmaceuticals, Inc. (3) · Glaukos Corporation (3) · Nantes University Hospital (3) · University of Sao Paulo (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Clearside Biomedical, Inc. (2) · Elisabeth-TweeSteden Ziekenhuis (2) · EndoGastric Solutions (2) · Intersect ENT (2) · Janssen Research & Development, LLC (2) · Mansoura University (2)
United States (87) · Germany (29) · France (26) · Italy (25) · Spain (23) · United Kingdom (23) · Poland (21) · Australia (20) · Canada (19) · Brazil (15) · Netherlands (15) · Czechia (14) · Hungary (14) · Israel (14) · China (13)
Pablo Velazquez-Martin, MD (5) · David Kandzari, MD (3) · Joanne Li (2) · Kazuomi Kario, MD (2) · Raymond Townsend, MD (2) · Ajay J Kirtane, M.D (1) · Amir Mostafa Shabana, MD (1) · Andrew Charles, MD (1) · Andrew Sharp, Prof. (1) · Anita P. Courcoulas, MD MPH FACS (1)
PMID 37314061, PMID 39526682, PMID 41534798, PMID 26699604, PMID 31420846, PMID 32034481, PMID 35085502, PMID 35085503, PMID 36246184, PMID 36246941, PMID 36787524, PMID 36897413, PMID 37294433, PMID 37585454, PMID 37865470, PMID 38158159, PMID 38280653, PMID 38382813, PMID 38722644, PMID 38758639, PMID 38814626, PMID 38852921, PMID 40388106, PMID 40668667, PMID 41712218, PMID 42753135, PMID 42771326, PMID 10379020, PMID 15713907, PMID 21466679, PMID 21768318, PMID 23442554, PMID 24554030, PMID 24884948, PMID 25448925, PMID 25808980, PMID 25824248, PMID 25872590, PMID 26992115, PMID 27939059, PMID 28000425, PMID 28859944, PMID 29091570, PMID 29191325, PMID 29420232, PMID 29443664, PMID 29743284, PMID 29803589, PMID 29803590, PMID 30392080
2014 (4), 2017 (3), 2018 (2), 2023 (2), 2019 (1), 2025 (1), M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR008084 (1), P30AG064198 (1), U01HD019897 (1), U10HD021364 (1), U10HD021373 (1)