9 completed, 1 withdrawn. 7 Phase 2, 2 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 6, Withdrawn 1 |
| Not applicable | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Efficacy and Safety of add-on Sarcosine in Patients With Major Depressive Disorder Sarcosine and SSRI, Placebo and SSRI - Major Depressive Disorder | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2021-08-26 | 2023-07-25 |
| Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia Sarcosine - Schizophrenia | Phase 2 | Completed | Medical University of Lodz | 70 | 2012-01-01 | 2016-09-16 |
| The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease Sarcosine Capsule, Placebo Capsule - Parkinson's Disease With Dementia | Not applicable | Completed | China Medical University Hospital | 30 | 2010-08-01 | 2013-08-22 |
| N-methylglycine (Sarcosine) Treatment for Depression citalopram, sarcosine - Major Depressive Disorder, Depression | Phase 2 | Completed | China Medical University Hospital | 40 | 2009-04-01 | 2011-07-12 |
| Treatment of N-methyl-D-aspartate (NMDA) Enhancers for Schizophrenia sarcosine, sarcosine+ BE, placebo - Schizophrenia | Phase 2 | Completed | Chang-Hua Hospital | 63 | 2009-03-01 | 2014-07-08 |
| A Study of the Effects of Sarcosine on Symptoms and Brain Glycine Levels in People With Schizophrenia Sarcosine - Schizophrenia | Not applicable | Completed | Massachusetts General Hospital | 68 | 2007-08-01 | 2012-09-18 |
| N-methyl Glycine (Sarcosine) for the Treatment of Obsessive Compulsive Disorder (OCD) N-methyl glycine - Obsessive Compulsive Disorder | Phase 2 | Completed | China Medical University Hospital | 30 | 2007-06-01 | 2009-12-29 |
| Sarcosine Preventive Therapy for Individuals At High Risk for Schizophrenia Sarcosine (N-methylglycine) - Schizophrenias, Psychoses | Phase 2 | Withdrawn | Herzog Hospital | 2006-08-01 | 2014-06-04 | |
| Sarcosine or D-Serine Add-on Treatment for Chronic Schizophrenia Sarcosine and D-serine - Schizophrenias, Psychoses | Phase 2 | Completed | China Medical University Hospital | 60 | 2005-01-01 | 2007-06-26 |
| Sarcosine (N-Methylglycine) Monotherapy for Schizophrenia Sarcosine - Schizophrenias, Psychoses | Phase 2 | Completed | China Medical University Hospital | 20 | 2004-12-01 | 2006-05-19 |
Schizophrenia (6) · Psychotic Disorders (3) · Depressive Disorder, Major (2) · Dementia (1) · Depression (1) · Obsessive-Compulsive Disorder (1) · Parkinson Disease (1)
China Medical University Hospital (5) · All India Institute of Medical Sciences, Bhubaneswar (1) · Chang-Hua Hospital (1) · Herzog Hospital (1) · Massachusetts General Hospital (1) · Medical University of Lodz (1)
Taiwan (6) · India (1) · Israel (1) · Poland (1) · United States (1)
A. Eden Evins, M.D., M.P.H. (1) · Bernard Lerer, M.D. (1) · Chieh-Liang Huang, MD (1) · Chon-Haw Tsai, MD, PHD (1) · Chun-yuan Lin, MD (1) · Dominik Strzelecki, MD, PhD (1) · Guochuan E Tsai, MD, PhD (1) · Guochuan E. Tsai, MD,PhD (1) · Hsien-Yuan Lane, M.D., Ph.D (1) · Hsien-Yuan Lane, MD,PhD (1) · Hsien-yuan Lane, MD,PHD (1) · Hsien-yuan Lane, MD,PhD (1) · Marc Kaufman, Ph.D. (1) · Rituparna Maiti, MD (1)
PMID 23562005, PMID 12813115, PMID 15939837, PMID 17389902, PMID 17659263, PMID 19376453, PMID 19887019, PMID 20975857, PMID 24612097, PMID 26150775, PMID 26306650, PMID 26501260, PMID 27555541, PMID 28245819, PMID 28928987, PMID 30627806, PMID 30738126, PMID 30807103, PMID 31328587, PMID 34510411, PMID 39180989, PMID 41929255
R01DA022276 (1)