86 completed, 12 terminated, 10 recruiting, 6 unknown. 47 Phase 2, 35 Phase 3, 32 Phase 1, 16 Phase 4, 12 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion | Phase 3 | Not yet recruiting | Cali Pharmaceuticals LLC | 112 | 2027-03-01 | 2026-10-21 |
| Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA) | Phase 1 | Not yet recruiting | VA Office of Research and Development | 40 | 2027-01-01 | 2026-07-15 |
| Effect of Low-Dose Esketamine Combined With Dexmedetomidine on the Incidence of Chronic Postsurgical Pain in Patients Undergoing Pancreatic Surgery Esketamine combined with dexmedetomidine, saline placebo - Chronic Pain, Postoperative | Phase 4 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 450 | 2026-12-01 | 2026-10-22 |
| Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study Psilocybin, Saline Placebo, Clonidine - Well-Being, Psychological, Psychedelic Experiences | Phase 1 | Not yet recruiting | University of Wisconsin, Madison | 120 | 2026-10-01 | 2026-09-29 |
| Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy saline placebo, Dexamethasone - Carbon Monoxide Poisoning, Carbon Monoxide Intoxication | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 20 | 2026-10-01 | 2026-08-14 |
| Precision Depression Adalimumab Trial Adalimumab Biosimilars Injection, Placebo - Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Daniel Moriarity | 60 | 2026-09-01 | 2026-09-29 |
| A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older C.difficile vaccine, Saline Placebo - Clostridoides Difficile Associated Disease | Phase 3 | Recruiting | Pfizer | 32500 | 2025-12-10 | 2026-10-13 |
| A Study of TLC590 for Postsurgical Pain Following Bunionectomy TLC590, Liposomal Bupivacaine, Saline Placebo - Postoperative Pain | Phase 3 | Active not recruiting | TLC Biopharmaceuticals, Inc. | 304 | 2025-11-17 | 2026-07-02 |
| Improving Vaccine Protection for Adults AS01 adjuvant (0.5 mL intramuscular), YF17D (Stamaril, Sanofi-Pasteur), Placebo (NaCl 09%, 0.5mL) - Immune System Responses and Trained Immunity After AS01 Administration, Healthy Adult | Phase 2 | Recruiting | Singapore General Hospital | 40 | 2025-11-06 | 2026-06-15 |
| Study of Tirzepatide for Recovery and Alcohol Use Management Tirzepatide, Saline Placebo - Alcohol Use Disorder (AUD) | Phase 2 | Recruiting | Brigham and Women's Hospital | 20 | 2025-09-15 | 2026-07-09 |
| Interleukin-15 to Promote Post-ART Control of HIV N-803, Saline placebo - HIV | Phase 2 | Enrolling by invitation | Michael Peluso, MD | 20 | 2025-08-19 | 2026-01-22 |
| Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee Temsirolimus, Saline placebo - Peripheral Artery Disease, Critical Limb Ischemia | Phase 3 | Recruiting | Mercator MedSystems, Inc. | 250 | 2025-07-30 | 2025-08-05 |
| Stellate Ganglion Morphine Infiltration on Myocardial I/R Injury Morphine, saline placebo - Acute Myocardial Infarction (AMI) | Not applicable | Recruiting | The Second Hospital of Anhui Medical University | 2588 | 2025-06-24 | 2025-07-04 |
| Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury Morphine, saline placebo - Acute Myocardial Infarction | Not applicable | Recruiting | The Second Hospital of Anhui Medical University | 166 | 2025-05-29 | 2025-12-17 |
| Carriage to Assess Protection of New Pneumococcal Vaccines - PCV15 PCV15, Streptococcus pneumoniae serotype 3, Placebo - Pneumococcal Disease, Pneumococcal Carriage | Phase 4 | Recruiting | University of Oxford | 106 | 2025-02-24 | 2025-04-15 |
| Phase 2B Study Assessing Pain Relief After Replacement of the Knee ATX101, bupivacaine hydrochloride, saline placebo - Total Knee Arthroplasty (Postoperative Pain) | Phase 2 | Completed | Allay Therapeutics, Inc. | 226 | 2025-02-03 | 2026-10-19 |
| CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial Calcium Gluconate, Vasopressin, saline placebo - Trauma, Hemorrhage | Phase 2 | Recruiting | Jason Sperry | 1050 | 2024-06-30 | 2026-09-29 |
| Tirofiban After Successful MT Recanalization in AIS Tirofiban, Saline placebo - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Completed | Xiang Luo | 1380 | 2024-04-09 | 2026-03-11 |
| Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome Sargramostim for Injection, Saline Placebo - Down Syndrome | Phase 2 | Withdrawn | University of Colorado, Denver | 2023-10-23 | 2025-04-02 | |
| CPL-01 in the Management of Postoperative Pain After Bunionectomy Local anesthetic injection of CPL-01, Naropin, 0.5% Injectable Solution, Placebo - Bunion, Post-operative Pain | Phase 3 | Completed | Cali Pharmaceuticals LLC | 616 | 2023-05-22 | 2026-04-30 |
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Pain, Postoperative (13) · Influenza, Human (9) · Bunion (5) · COVID-19 (5) · Pain (4) · Delirium (3) · Meningococcal Infections (3) · Stroke (3) · Agnosia (2) · Diabetes Insipidus (2) · Heart Failure (2) · Hemorrhage (2) · Meningitis (2) · Meningitis, Meningococcal (2) · Migraine Disorders (2)
GlaxoSmithKline (9) · Heron Therapeutics (6) · University of Saskatchewan (5) · Assiut University (4) · University of Oxford (4) · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (3) · Cinnagen (3) · Novavax (3) · Stem Cell Therapeutics Corp. (3) · Weill Medical College of Cornell University (3) · Austin Health (2) · Baylor College of Medicine (2) · Cali Pharmaceuticals LLC (2) · Idera Pharmaceuticals, Inc. (2) · Merck Sharp & Dohme LLC (2)
United States (75) · Canada (18) · China (10) · United Kingdom (9) · Australia (6) · Italy (5) · Egypt (4) · Mexico (4) · Belgium (3) · Finland (3) · Germany (3) · India (3) · Iran (3) · Japan (3) · Poland (3)
Ozlem Equils, MD (3) · Payam Tabarsi, M.D. (3) · Michael C Reade, MBBS DPhil (2) · Michael D Hill, MD (2) · Nigel Thomas, Ph.D (2) · Professor Helen McShane (2) · Steven C Cramer, MD (2) · Adi Cohen, MD (1) · Alice Bexon, MD (1) · Amir Abdipour, MD (1)
PMID 38769033, PMID 34284613, PMID 18396361, PMID 19383827, PMID 20164251, PMID 20236548, PMID 20438039, PMID 22129980, PMID 22315336, PMID 23102686, PMID 23110320, PMID 23527091, PMID 23543660, PMID 24519631, PMID 24588854, PMID 24684466, PMID 24764186, PMID 25715157, PMID 25733584, PMID 25879974, PMID 25947955, PMID 26358172, PMID 26975647, PMID 27876460, PMID 28522338, PMID 28984909, PMID 29100709, PMID 29443825, PMID 29452372, PMID 30926189, PMID 31056697, PMID 31113830, PMID 31609443, PMID 31843865, PMID 32379201, PMID 32526188, PMID 32561266, PMID 32876328, PMID 32889792, PMID 32943001, PMID 32970104, PMID 33778150, PMID 33849367, PMID 34002866, PMID 34318438, PMID 34601736, PMID 35084480, PMID 35120836, PMID 35307513, PMID 35436611
1IK2CX001495-01 (1), 2005 (1), 2014 (1), 2015 (1), 2018 (1), 2023 (1), K23HL078760 (1), K23RR021874 (1), R01DA032922 (1), R01HL126638 (1), R01HL128526 (1), R21HD055501 (1), R61AG074859 (1), U01HL125205 (1), U10HL110262 (1)