11 completed, 2 terminated. 12 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 10, Terminated 2 |
| Phase 1 | 2 | Completed 2 |
Follow sagopilone: new trials by email Literature Review of sagopilone trials Research Report on sagopilone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prevention of Sagopilone-induced Neurotoxicity With Acetyl-L-Carnitine (ALC) Sagopilone 16 mg/m^2 i.v., Acetyl-L-Carnitine (ALC) 1000 mg tid, HRPC only: Prednisone or Prednisolone 5 mg bid, Sagopilone 16 mg/m^2 i.v. and placebo 1000 mg tid, HRPC only: Prednisone or Prednisolone 5 mg bid - Prostate Cancer, Ovarian Cancer | Phase 2 | Completed | Bayer | 150 | 2008-08-01 | 2014-10-28 |
| ZK219477 (Sagopilone) in Patients With Breast Cancer and Brain Metastases ZK219477 - Breast Cancer, CNS Disease | Phase 2 | Terminated | Nancy Lin, MD | 15 | 2007-07-01 | 2013-03-14 |
| Phase II Trial Of ZK-EPO (ZK 219477) (Sagopilone) In Metastatic Melanoma ZK-EPO - Melanoma | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 35 | 2007-05-01 | 2013-12-11 |
| Investigation of Mass Balance of the Test Drug and Major Metabolites Sagopilone (BAY 86-5302, ZK 219477) - Neoplasms | Phase 1 | Completed | Bayer | 7 | 2007-01-01 | 2015-12-14 |
| Epothilone ZK-219477 in Treating Patients With Recurrent Glioblastoma sagopilone, fluorescence in situ hybridization, gene expression analysis - Brain and Central Nervous System Tumors | Phase 2 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 38 | 2006-12-01 | 2012-09-24 |
| ZK-Epo Given With Carboplatin in Patients With Recurrent Ovarian Cancer Sagopilone (ZK 219477) + carboplatin - Ovarian Neoplasms | Phase 2 | Completed | Bayer | 45 | 2006-08-24 | 2021-04-08 |
| ZK-Epo Given With Prednisone in Patients With Metastatic Androgen-independent Prostate Cancer Sagopilone (ZK 219477) + prednisone - Prostate Cancer | Phase 2 | Completed | Bayer | 53 | 2006-08-01 | 2021-04-08 |
| A Study of a New Chemotherapy Agent in Combination With Cisplatin to Treat Small Cell Lung Cancer Sagopilone (BAY86-5302, ZK 219477), Cisplatin - Carcinoma, Small Cell | Phase 1 / Phase 2 | Completed | Bayer | 26 | 2006-07-01 | 2014-11-04 |
| Safety and Efficacy Study of a New Chemotherapy Agent to Treat Small Cell Lung Cancer Sagopilone (BAY86-5302, ZK 219477) - Small Cell Lung Carcinoma | Phase 2 | Terminated | Bayer | 10 | 2006-04-01 | 2015-12-31 |
| Evaluation of a New Agent for Treatment of Advanced Stage Breast Cancer Sagopilone (ZK 219477) - Breast Neoplasm | Phase 2 | Completed | Bayer | 65 | 2006-04-01 | 2015-12-10 |
| Safety and Efficacy Study of a New Chemotherapy Agent to Treat Metastatic Breast Cancer Sagopilone (BAY86-5302, ZK 219477) - Breast Neoplasms, Breast Cancer, Metastatic | Phase 2 | Completed | Bayer | 82 | 2005-12-01 | 2014-12-02 |
| Efficacy and Safety Study of ZK219477 in Patients With Recurrent Ovarian Cancer Sagopilone (BAY86-5302 , ZK219477) - Ovarian Neoplasms | Phase 2 | Completed | Bayer | 63 | 2005-11-01 | 2015-12-31 |
| Safety and Efficacy Study of a New Chemotherapy Agent to Treat Non-small-cell Lung Cancer Sagopilone (BAY86-5302, ZK 219477) - Carcinoma, Non Small Cell Lung | Phase 2 | Completed | Bayer | 128 | 2005-08-01 | 2014-12-04 |
Breast Neoplasms (3) · Ovarian Neoplasms (3) · Brain Neoplasms (2) · Prostatic Neoplasms (2) · Small Cell Lung Carcinoma (2) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Small Cell (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Glioblastoma (1) · Gliosarcoma (1) · Lung Neoplasms (1) · Melanoma (1) · Neoplasm Metastasis (1) · Neoplasms (1)
Bayer (10) · European Organisation for Research and Treatment of Cancer - EORTC (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Nancy Lin, MD (1)
United States (5) · Germany (4) · Belgium (3) · Canada (2) · France (2) · Italy (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Bulgaria (1) · Netherlands (1) · Poland (1) · Slovenia (1) · Spain (1) · Switzerland (1)
Nancy Lin, MD (1) · Roger Stupp, MD (1) · Ronald DeConti, M.D. (1)
PMID 20697802, PMID 21321091, PMID 21372124, PMID 22108514, PMID 22850553, PMID 23522488, PMID 24105751
2005 (4), 2008 (1)