12 completed, 3 recruiting, 2 active not recruiting, 1 terminated. 11 Phase 2, 9 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 8, Active not recruiting 1, Recruiting 1, Terminated 1 |
| Phase 1 | 9 | Completed 6, Active not recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Ruxolitinib Phosphate: new trials by email Literature Review of Ruxolitinib Phosphate trials Research Report on Ruxolitinib Phosphate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Flonoltinib Maleate for Intermediate or High-Risk Myelofibrosis Flonoltinib 75mg, Ruxolitinib Phosphate - MF | Phase 3 | Recruiting | Chengdu Zenitar Biomedical Technology Co., Ltd | 105 | 2026-02-13 | 2026-08-13 |
| Ruxolitinib in Combination With CHOP Chemotherapy for the Treatment of Untreated Nodal T-Follicular Helper Cell Lymphomas Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Follicular Helper T-Cell Lymphoma, Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type | Phase 1 | Recruiting | City of Hope Medical Center | 20 | 2025-12-16 | 2026-06-05 |
| Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome Biospecimen Collection, Chest Computed Tomography, Echocardiography - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Recruiting | City of Hope Medical Center | 40 | 2024-08-01 | 2026-10-14 |
| Pembrolizumab and Ruxolitinib Phosphate in Treating Patients With Metastatic Stage IV Triple Negative Breast Cancer Laboratory Biomarker Analysis, Pembrolizumab, Ruxolitinib Phosphate - Metastatic Malignant Neoplasm in the Bone, Stage IV Breast Cancer AJCC v6 and v7 | Phase 1 | Completed | Mayo Clinic | 12 | 2017-12-06 | 2024-01-31 |
| VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer Biopsy, Computed Tomography, Fluorine F 18 Tetrafluoroborate - Metastatic Endometrial Carcinoma, Recurrent Endometrial Adenocarcinoma | Phase 1 | Active not recruiting | Mayo Clinic | 34 | 2017-09-15 | 2026-07-21 |
| Ruxolitinib Phosphate in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Ruxolitinib, Ruxolitinib Phosphate - Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Untreated Chronic Lymphocytic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 1 | 2017-03-08 | 2021-04-21 |
| Ruxolitinib Phosphate, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Carboplatin, Paclitaxel, Ruxolitinib Phosphate - Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma | Phase 1 / Phase 2 | Completed | NRG Oncology | 147 | 2016-11-14 | 2025-05-25 |
| Ruxolitinib Phosphate and Chemotherapy Given Before and After Reduced Intensity Donor Stem Cell Transplant in Treating Patients With Myelofibrosis Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine, Fludarabine Phosphate - Primary Myelofibrosis, Secondary Myelofibrosis | Phase 1 | Completed | City of Hope Medical Center | 18 | 2016-11-13 | 2023-12-12 |
| Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia Cyclophosphamide, Cytarabine, Dasatinib - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 1 | Completed | OHSU Knight Cancer Institute | 7 | 2016-01-13 | 2020-05-26 |
| Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host Disease During Reduced Intensity Donor Hematopoietic Cell Transplant in Patients With Myelofibrosis Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Fludarabine Phosphate - Acute Myeloid Leukemia in Remission, Primary Myelofibrosis | Phase 1 | Withdrawn | City of Hope Medical Center | 2015-11-01 | 2016-09-14 | |
| Ruxolitinib Phosphate or Dasatinib With Chemotherapy in Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia Cyclophosphamide, Cytarabine, Dasatinib - Recurrent B Acute Lymphoblastic Leukemia, Recurrent Ph-Like Acute Lymphoblastic Leukemia | Phase 2 | Terminated | M.D. Anderson Cancer Center | 11 | 2015-07-15 | 2025-06-08 |
| Ruxolitinib Phosphate and Decitabine in Treating Patients With Relapsed or Refractory or Post Myeloproliferative Acute Myeloid Leukemia Decitabine, Laboratory Biomarker Analysis, Ruxolitinib Phosphate - Blasts More Than 20 Percent of Bone Marrow Nucleated Cells, Blasts More Than 20 Percent of Peripheral Blood White Cells | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 30 | 2015-02-12 | 2025-06-08 |
| Ruxolitinib Phosphate in Reducing Fatigue in Patients With Chronic Lymphocytic Leukemia Questionnaire Administration, Ruxolitinib Phosphate - Chronic Lymphocytic Leukemia | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 10 | 2014-09-02 | 2026-09-03 |
| Ruxolitinib Phosphate in Treating Patients With Chronic Neutrophilic Leukemia or Atypical Chronic Myeloid Leukemia Laboratory Biomarker Analysis, Quality-of-Life Assessment, Questionnaire Administration - Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, Chronic Neutrophilic Leukemia | Phase 2 | Completed | OHSU Knight Cancer Institute | 51 | 2014-07-08 | 2020-11-16 |
| Ruxolitinib Phosphate and Danazol in Treating Anemia in Patients With Myelofibrosis ruxolitinib phosphate, danazol, quality-of-life assessment - Anemia, Primary Myelofibrosis | Phase 2 | Completed | Mayo Clinic | 14 | 2013-04-01 | 2017-10-18 |
| Ruxolitinib Phosphate and Azacytidine in Treating Patients With Myelofibrosis or Myelodysplastic Syndrome/Myeloproliferative Neoplasm Azacitidine, Laboratory Biomarker Analysis, Ruxolitinib Phosphate - Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable, Myelofibrosis Transformation in Essential Thrombocythemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 121 | 2013-03-13 | 2026-03-31 |
| Ruxolitinib Phosphate to Treat Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma After Stem Cell Transplant Laboratory Biomarker Analysis, Ruxolitinib Phosphate - Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Mature T- and NK-Cell Non-Hodgkin Lymphoma | Phase 2 | Completed | University of Nebraska | 71 | 2011-08-12 | 2023-10-05 |
| INCB18424 in Treating Young Patients With Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease ruxolitinib phosphate, laboratory biomarker analysis, pharmacological study - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 | Completed | Children's Oncology Group | 49 | 2010-09-01 | 2014-10-23 |
| A Dose Ranging Study of the Effect of Ruxolitinib Phosphate Cream When Applied to Participants With Plaque Psoriasis Placebo Cream, Ruxolitinib Phosphate - Psoriasis | Phase 2 | Completed | Incyte Corporation | 199 | 2008-10-28 | 2022-02-09 |
Primary Myelofibrosis (5) · Leukemia, Myeloid, Acute (4) · Leukemia, Lymphocytic, Chronic, B-Cell (3) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (3) · Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (2) · Lymphoma, T-Cell (2) · Myelodysplastic Syndromes (2) · Myelodysplastic-Myeloproliferative Diseases (2) · Myeloproliferative Disorders (2) · Polycythemia Vera (2) · Anemia (1) · Burkitt Lymphoma (1) · Endometrial Neoplasms (1) · Fallopian Tube Neoplasms (1) · Leukemia (1)
M.D. Anderson Cancer Center (5) · City of Hope Medical Center (4) · Mayo Clinic (3) · OHSU Knight Cancer Institute (2) · Chengdu Zenitar Biomedical Technology Co., Ltd (1) · Children's Oncology Group (1) · Incyte Corporation (1) · NRG Oncology (1) · University of Nebraska (1)
United States (18) · China (1)
Haris Ali (3) · Alessandra Ferrajoli (1) · Charles N Landen (1) · Christina Poh (1) · Donald W Northfelt (1) · Farhad Ravandi-Kashani (1) · Jamie N. Bakkum-Gamez, M.D. (1) · Julie M Vose, MD, MBA (1) · Kim-Hien Dao (1) · Miao Jia, Doctor (1) · Mignon Loh, MD (1) · Monica Luchi, M.D. (1) · Naval Daver, MD (1) · Nitin Jain (1) · Niu Ting, Doctor (1)
PMID 25180155, PMID 28089238, PMID 29134664, PMID 30185431, PMID 31880950, PMID 33942298, PMID 34581764, PMID 38776484, PMID 42304430
P30CA033572 (2), P30CA015083 (1), P30CA016672 (1), P30CA036727 (1), P30CA069533 (1), R01CA207240 (1), U10CA180868 (1)