7 completed, 4 terminated, 1 no longer available, 1 withdrawn. 7 Phase 1, 5 Phase 2, 3 Phase 3.
By phase and status
Follow rovalpituzumab tesirine: new trials by email Literature Review of rovalpituzumab tesirine trials Research Report on rovalpituzumab tesirine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
A Long-Term Study of Rovalpituzumab Tesirine rovalpituzumab tesirine - Cancer | Phase 2 | Completed | 3 | 2018-09-10 | 2021-01-05 |
Study Evaluating the Safety of Rovalpituzumab Tesirine for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Small Cell Lung Cancer Dexamethasone, Rovalpituzumab tesirine - Small Cell Lung Cancer | Phase 3 | Withdrawn | | 2018-03-15 | 2018-12-26 |
A Study on the Safety and Tolerability of Rovalpituzumab Tesirine in Japanese Patients With Advanced, Recurrent Small Cell Lung Cancer Rovalpituzumab tesirine - Small Cell Lung Cancer | Phase 1 | Completed | 29 | 2017-04-28 | 2021-08-03 |
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) Rovalpituzumab tesirine, Topotecan, Dexamethasone - Small Cell Lung Cancer | Phase 3 | Completed | 444 | 2017-04-11 | 2021-02-23 |
A Study of Rovalpituzumab Tesirine Administered in Combination With Nivolumab and With or Without Ipilimumab for Adults With Extensive-Stage Small Cell Lung Cancer Ipilimumab, Nivolumab, Rovalpituzumab tesirine - Small Cell Lung Cancer | Phase 1 / Phase 2 | Terminated | 42 | 2017-03-30 | 2020-07-17 |
A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU) Placebo for dexamethasone, Placebo for rovalpituzumab tesirine, Rovalpituzumab tesirine - Small Cell Lung Cancer | Phase 3 | Terminated | 748 | 2017-02-07 | 2021-07-29 |
A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors Venetoclax, Rovalpituzumab Tesirine, ABBV-181 - Advanced Solid Tumors | Phase 1 | Completed | 182 | 2016-12-14 | 2022-04-14 |
A Study of Rovalpituzumab Tesirine (SC16LD6.5) in the Frontline Treatment of Patients With Extensive Stage Small Cell Lung Cancer Rovalpituzumab Tesirine, Cisplatin, Etoposide - Small Cell Lung Cancer | Phase 1 | Terminated | 28 | 2016-10-01 | 2020-03-12 |
Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors Rovalpituzumab tesirine, Dexamethasone - Malignant Melanoma, Medullary Thyroid Cancer | Phase 1 / Phase 2 | Terminated | 200 | 2016-09-23 | 2020-10-19 |
A Study of Rovalpituzumab Tesirine to Study Cardiac Ventricular Repolarization in Subjects With Small Cell Lung Cancer Rovalpituzumab Tesirine - Small Cell Lung Carcinoma | Phase 1 | Completed | 46 | 2016-09-01 | 2018-09-24 |
Study of Rovalpituzumab Tesirine (SC16LD6.5) for Third-Line and Later Treatment of Subjects With Relapsed or Refractory Delta-Like Protein 3-Expressing Small Cell Lung Cancer Rovalpituzumab tesirine - Small Cell Lung Cancer | Phase 2 | Completed | 342 | 2016-01-25 | 2021-07-30 |
Rovalpituzumab Tesirine (SC16LD6.5) in Recurrent Small Cell Lung Cancer Rovalpituzumab tesirine (SC16LD6.5) - Recurrent Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | 82 | 2013-07-01 | 2018-08-09 |
Expanded Access to Rovalpituzumab Tesirine rovalpituzumab tesirine - Small Cell Lung Cancer | | No longer available | | | 2019-09-10 |
Conditions studied
Small Cell Lung Carcinoma (11) · Neoplasms (6) · Carcinoma, Hepatocellular (1) · Carcinoma, Medullary (1) · Carcinoma, Merkel Cell (1) · Carcinoma, Non-Small-Cell Lung (1) · Cholangiocarcinoma (1) · Glioblastoma (1) · Head and Neck Neoplasms (1) · Melanoma (1) · Mesothelioma (1) · Neoplasm Metastasis (1) · Ovarian Neoplasms (1) · Recurrence (1) · Stomach Neoplasms (1)
Sponsors
AbbVie (11) · Stemcentrx (2)
Countries
United States (10) · Canada (5) · Australia (4) · France (4) · Germany (4) · Japan (4) · Spain (4) · Belgium (3) · Brazil (3) · Italy (3) · Sweden (3) · Taiwan (3) · United Kingdom (3) · Austria (2) · Belarus (2)
Top investigators
Daniel Da Costa, PharmD (1) · Donald Strickland, MD (1)
Results publications
PMID 29290251, PMID 27932068, PMID 32372416, PMID 32770720, PMID 34216247, PMID 34329846, PMID 35034046
NIH funding
2016 (4), 2015 (1), 2017 (1)