20 completed, 2 terminated, 1 unknown. 23 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 23 | Completed 20, Terminated 2, Unknown 1 |
Follow Rifabutin: new trials by email Literature Review of Rifabutin trials Research Report on Rifabutin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Rifabutin and MK-4646 in Healthy Participants (MK-4646-004) MK-4646, Rifabutin - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 18 | 2025-10-28 | 2026-01-29 |
| A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy Adults VH4524184, Itraconazole, Rifabutin - HIV Infections | Phase 1 | Completed | ViiV Healthcare | 126 | 2025-07-07 | 2026-03-09 |
| Study to Investigate the Penetration of Rifabutin Into the Lung After Multiple Intravenous Administrations of BV100 BV100 - Bacterial Infections | Phase 1 | Completed | BioVersys AG | 35 | 2023-09-01 | 2025-01-14 |
| To Evaluate the Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of BV100 BV100 (300 mg), Itraconazole 200 mg - Bacterial Infections | Phase 1 | Completed | BioVersys AG | 16 | 2023-02-01 | 2023-11-21 |
| Drug-Drug Interaction Study of Vesatolimod in Adults With HIV-1 Who Have Very Low or Undetectable Virus Levels Vesatolimod, Cobicistat, Voriconazole - Human Immunodeficiency Virus Type 1 (HIV-1) Infection | Phase 1 | Terminated | Gilead Sciences | 18 | 2022-08-19 | 2024-12-03 |
| Pharmacokinetics and Safety of BV100 Administered as Single Intravenous Infusion to Subjects With Renal Impairment BV100 - Renal Impairment | Phase 1 | Completed | BioVersys AG | 48 | 2021-10-08 | 2023-01-18 |
| The Effect of Moderate CYP3A Inducer Rifabutin on the Pharmacokinetics of Zanubrutinib in Healthy Males Zanubrutinib, Rifabutin - Healthy, Male | Phase 1 | Completed | BeiGene | 13 | 2020-07-29 | 2024-10-26 |
| Pharmacokinetics Study to Evaluate Drug-Drug Interactions and Safety of Elpida® in Co-Administration With Other Drugs Elpida®, Rifampin, Rifabutin - HIV-1-infection | Phase 1 | Completed | Viriom | 56 | 2018-11-14 | 2022-01-26 |
| Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects Cabotegravir, Rifabutin - Infection, Human Immunodeficiency Virus, HIV Infections | Phase 1 | Completed | ViiV Healthcare | 15 | 2017-06-06 | 2020-09-17 |
| Drug-drug Interaction (DDI) Rifabutin BMS-663068, Rifabutin, Ritonavir - Infection, Human Immunodeficiency Virus | Phase 1 | Completed | ViiV Healthcare | 102 | 2014-05-14 | 2017-09-25 |
| A Drug Interaction Study Investigating the Effect of Rifabutin on the Pharmacokinetics of Maraviroc Rifabutin, Maraviroc - HIV Infection, HIV-1 Infection | Phase 1 | Completed | Ottawa Hospital Research Institute | 15 | 2013-06-01 | 2020-03-10 |
| A Study to Explore the Pharmacokinetics of Rilpivirine With Rifabutin in Healthy Participants Rilpivirine, Rifabutin - Healthy | Phase 1 | Completed | Janssen R&D Ireland | 20 | 2012-04-01 | 2014-03-28 |
| TMC207 +/- Rifabutin/Rifampin Rifabutin, Rifampin, TMC207 - Tuberculosis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 33 | 2011-10-21 | 2017-04-21 |
| Phase 1, Open Label, Two Arm, Fixed Sequence Study to Evaluate the Effect of Rifampin and Rifabutin on GSK1349572 Pharmacokinetics in Healthy Male and Female Volunteers GSK1349572, Rifampin, Rifabutin - Infection, Human Immunodeficiency Virus | Phase 1 | Completed | ViiV Healthcare | 27 | 2011-05-01 | 2017-06-08 |
| Dosing, Safety and Pharmacokinetic Profile of Rifabutin in Children Receiving Concomitant Treatment With Kaletra Mycobutin - Children With Confirmed HIV Infection, Receiving ART Regimen Containing 2 NRTIs + LPV/RTV at Standard Dose | Phase 1 | Unknown | Harriet Shezi Children's Clinic | 40 | 2010-11-01 | 2010-12-14 |
| Drug Interaction Study Between Rifabutin And Lersivirine (UK-453,061) Lersivirine, Rifabutin - Healthy Volunteers | Phase 1 | Completed | Pfizer | 18 | 2010-05-01 | 2010-09-21 |
| A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects lopinavir/ritonavir, rifabutin - HIV, Tuberculosis | Phase 1 | Terminated | Abbott | 15 | 2008-08-01 | 2010-11-02 |
| Drug Interaction Study Rifabutin, Rifabutin + Atazanavir + Ritonavir - Antivirals/HIV | Phase 1 | Completed | Bristol-Myers Squibb | 85 | 2008-04-01 | 2013-01-31 |
| Interaction of Buprenorphine With HIV Medications and Tuberculosis Medications Fosamprenavir/Ritonavir, Darunavir/Ritonavir, Rifampin - Opioid Dependency, HIV Infections | Phase 1 | Completed | University of California, San Francisco | 63 | 2008-04-01 | 2014-05-06 |
| Effects of Steady-state TPV/RTV on the Single-dose Pharmacokinetics of Rifabutin and the Effects of Single-dose Rifabutin on the Steady-state Pharmacokinetics of TPV in Healthy Adult Volunteers Tipranavir, Ritonavir, Rifabutin - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 24 | 2003-08-01 | 2014-09-29 |
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HIV Infections (8) · Acquired Immunodeficiency Syndrome (5) · Infections (4) · Tuberculosis (4) · Bacterial Infections (3) · AIDS-Related Opportunistic Infections (2) · AIDS-Related Complex (1) · Mycobacterium avium-intracellulare Infection (1) · Mycoses (1) · Renal Insufficiency (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · ViiV Healthcare (4) · BioVersys AG (3) · Abbott (1) · BeiGene (1) · Boehringer Ingelheim (1) · Bristol-Myers Squibb (1) · Gilead Sciences (1) · Harriet Shezi Children's Clinic (1) · Janssen R&D Ireland (1) · Merck Sharp & Dohme LLC (1) · Ottawa Hospital Research Institute (1) · Pfizer (1) · University of California, San Francisco (1) · Viriom (1)
United States (13) · Hungary (2) · Austria (1) · Belgium (1) · Canada (1) · Russia (1) · Singapore (1) · South Africa (1) · United Kingdom (1)
Constance Benson (2) · Lisa Husband, MD (2) · Alla Andreeva, PhD (1) · Angela Nilius, MD (1) · Charles Flexner (1) · Diane Havlir (1) · Donald W Cameron, MD (1) · Elena Smolyarchuk, PhD (1) · Elinore F McCance-Katz, M.D., Ph.D. (1) · Judith Currier (1)
PMID 15470330, PMID 21712242, PMID 25281400, PMID 26832753, PMID 29061739, PMID 31647836, PMID 35604212, PMID 37145975, PMID 40952649
2017 (1)