11 completed. 11 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 11 |
Follow reolysin: new trials by email Literature Review of reolysin trials Research Report on reolysin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pelareorep and Paclitaxel Injection in Chinese Patients With Advanced or Metastatic Breast Cancer Pelareorep - Advanced or Metastatic Breast Cancer | Phase 1 | Completed | Adlai Nortye Biopharma Co., Ltd. | 15 | 2021-10-11 | 2023-11-22 |
| Dexamethasone, Carfilzomib, & Nivolumab With Pelareorep for Relapsed/Refractory Multiple Myeloma Carfilzomib, Dexamethasone, Nivolumab - Recurrent Plasma Cell Myeloma | Phase 1 | Completed | Emory University | 23 | 2018-10-24 | 2023-10-06 |
| Study of Pembrolizumab With REOLYSIN® and Chemotherapy in Patients With Advanced Pancreatic Adenocarcinoma REOLYSIN®, Chemotherapy, Gemcitabine - Pancreatic Adenocarcinoma | Phase 1 | Completed | Oncolytics Biotech | 11 | 2015-12-01 | 2018-09-13 |
| Wild-Type Reovirus, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Bortezomib, Dexamethasone, Laboratory Biomarker Analysis - Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | Phase 1 | Completed | University of Southern California | 14 | 2015-08-21 | 2023-08-14 |
| Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors Laboratory Biomarker Analysis, Sargramostim, Wild-type Reovirus - Childhood Astrocytoma, Childhood Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Completed | Mayo Clinic | 6 | 2015-06-21 | 2023-04-24 |
| Wild-Type Reovirus in Combination With Carfilzomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Carfilzomib, Dexamethasone, Laboratory Biomarker Analysis - Anemia, Recurrent Multiple Myeloma | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 2014-12-09 | 2024-05-17 |
| Viral Therapy in Treating Patients With Relapsed or Refractory Multiple Myeloma Diagnostic Laboratory Biomarker Analysis, Wild-type Reovirus - Light Chain Deposition Disease, Refractory Plasma Cell Myeloma | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 2012-04-01 | 2015-04-15 |
| Study of REOLYSIN® in Combination With FOLFIRI and Bevacizumab in FOLFIRI Naive Patients With KRAS Mutant Metastatic Colorectal Cancer REOLYSIN®, Irinotecan, Leucovorin - KRAS Mutant Metastatic Colorectal Cancer | Phase 1 | Completed | Oncolytics Biotech | 36 | 2010-12-01 | 2018-12-19 |
| Viral Therapy in Treating Young Patients With Relapsed or Refractory Solid Tumors wild-type reovirus, cyclophosphamide, laboratory biomarker analysis - Unspecified Childhood Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 26 | 2010-12-01 | 2014-05-13 |
| Viral Therapy in Treating Patients With Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer That Did Not Respond to Platinum Chemotherapy Laboratory Biomarker Analysis, Wild-type Reovirus - Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 70 | 2008-04-01 | 2016-08-08 |
| Safety and Efficacy Study of REOLYSIN® in the Treatment of Recurrent Malignant Gliomas REOLYSIN® - Malignant Glioma | Phase 1 | Completed | Oncolytics Biotech | 18 | 2006-07-01 | 2014-10-02 |
Multiple Myeloma (4) · Glioma (2) · Neoplasms (2) · Anemia (1) · Astrocytoma (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Diffuse Intrinsic Pontine Glioma (1) · Fallopian Tube Neoplasms (1) · Glioblastoma (1) · Medulloblastoma (1) · Neuroectodermal Tumors, Primitive (1) · Oligodendroglioma (1) · Ovarian Neoplasms (1) · Rhabdoid Tumor (1)
National Cancer Institute (NCI) (4) · Oncolytics Biotech (3) · Adlai Nortye Biopharma Co., Ltd. (1) · Emory University (1) · Mayo Clinic (1) · University of Southern California (1)
United States (10) · Canada (1) · China (1)
Craig C Hofmeister (1) · Craig Hofmeister (1) · Craig Hofmeister, MD, MPH (1) · David Cohn (1) · E. Anders Kolb (1) · James M Markert, MD (1) · Kevin Kelly, MD (1) · Richard Bram (1) · Sukeshi Patel Arora, MD (1) · Wei Li, M.D. (1)
P30CA016058 (3), U01CA076576 (3), P30CA014089 (1), P30CA015083 (1), P30CA138292 (1), U01CA097452 (1), UM1CA186691 (1), UM1CA186712 (1)