11 completed, 2 withdrawn, 1 recruiting, 1 unknown. 5 Phase 2, 4 Phase 3, 3 Phase 4, 2 Phase 1, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Unknown 1, Withdrawn 1 |
| Phase 3 | 4 | Completed 3, Withdrawn 1 |
| Phase 4 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 2 |
| Early Phase 1 | 1 | Recruiting 1 |
Follow recombinant tissue plasminogen activator: new trials by email Literature Review of recombinant tissue plasminogen activator trials Research Report on recombinant tissue plasminogen activator
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Alteplase Through an Indwelling Pleural Catheter for the Management of Symptomatic Septated Malignant Pleural Effusion Alteplase, Placebo Administration - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Early Phase 1 | Recruiting | M.D. Anderson Cancer Center | 30 | 2023-08-17 | 2026-08-17 |
| Direct Mechanical Thrombectomy Versus Bridging Therapy Trevo and or Merci devices for stent retreival, Penumbra system for stent aspiration, recombinant tissue plasminogen activator - Thrombectomy, Ischemic Stroke | Phase 4 | Completed | Alexandria University | 51 | 2019-07-01 | 2022-01-03 |
| Pediatric High-Risk Deep Venous Thrombosis Lytic Outcomes Trial Recombinant tissue plasminogen activator (rt-PA), Standard Anticoagulation Therapy - Deep Vein Thrombosis, Post-Thrombotic Syndrome | Phase 3 | Withdrawn | University of Colorado, Denver | 2018-07-01 | 2018-08-10 | |
| Thrombolysis Endovascular Treatment of Pulmonary Embolism recombinant tissue plasminogen activator - Pulmonary Embolism, Acute Pulmonary Embolism | Phase 3 | Completed | Beijing Tsinghua Chang Gung Hospital | 50 | 2017-01-01 | 2020-11-30 |
| Thrombolysis Outcome in Ischemic Stroke Alteplase - Stroke, Acute, Thrombolytic Therapy | Completed | Mazandaran University of Medical Sciences | 214 | 2017-01-01 | 2020-07-09 | |
| Optimum Duration of Acoustic Pulse Thrombolysis Procedure in Acute Pulmonary Embolism Ekosonic® Endovascular Device ultrasonic infusion catheter, Recombinant tissue plasminogen activator - Pulmonary Embolism and Thrombosis | Phase 4 | Completed | Boston Scientific Corporation | 131 | 2015-06-12 | 2021-07-19 |
| Dose-effect Relationship of Rt-PA on ICH Evacuation YL-1 type of intracranial hematoma puncture needle, rt-PA - Hypertensive Intracerebral Hemorrhage | Phase 2 | Unknown | Tongji Hospital | 108 | 2015-06-01 | 2015-06-16 |
| Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke Sulfur hexafluoride + ultrasounds, Recombinant tissue plasminogen activator - Cerebrovascular Stroke | Phase 2 | Completed | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 24 | 2012-08-01 | 2015-08-10 |
| Submassive and Massive Pulmonary Embolism Treatment With Ultrasound Accelerated Thrombolysis Therapy recombinant tissue plasminogen activator, EKOS EkoSonic Endovascular System - Pulmonary Embolism, Acute Pulmonary Embolism | Phase 3 | Completed | Boston Scientific Corporation | 150 | 2012-06-07 | 2021-07-19 |
| Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke Penumbra™ System, Recombinant tissue plasminogen activator - Stroke | Phase 2 | Withdrawn | Hospital de Clinicas de Porto Alegre | 2010-05-01 | 2015-09-03 | |
| Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis Recombinant tissue plasminogen activator (rt-PA) - Deep Vein Thrombosis, Venous Thrombosis | Phase 3 | Completed | Washington University School of Medicine | 692 | 2009-11-01 | 2018-03-29 |
| In Vivo Angiostatin Generation Using Tissue Plasminogen Activator and Captopril in Treating Patients With Progressive Metastatic Cancer recombinant tissue plasminogen activator, captopril - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 / Phase 2 | Completed | Northwestern University | 2003-07-01 | 2012-06-11 | |
| Interventional Management of Stroke (IMS) II Study Recombinant tissue plasminogen activator, Low-intensity ultrasound - Stroke | Phase 2 | Completed | University of Cincinnati | 81 | 2003-01-01 | 2012-07-25 |
| Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in China rt-PA - Pulmonary Embolism, Thromboembolism | Phase 4 | Completed | Beijing Chao Yang Hospital | 118 | 2002-06-01 | 2008-10-29 |
| Treatment for Blood Clots in the Veins of the Legs Recombinant Tissue Plasminogen Activator, Heparin, Warfarin - Embolism, Thrombophlebitis | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 20 | 1998-02-01 | 2008-03-04 |
Pulmonary Embolism (4) · Stroke (4) · Thrombosis (4) · Embolism (2) · Ischemic Stroke (2) · Postthrombotic Syndrome (2) · Venous Thrombosis (2) · Cerebral Hemorrhage (1) · Hematologic Neoplasms (1) · Intracranial Hemorrhage, Hypertensive (1) · Postphlebitic Syndrome (1) · Thromboembolism (1) · Thrombophlebitis (1) · Venous Thromboembolism (1)
Boston Scientific Corporation (2) · Alexandria University (1) · Beijing Chao Yang Hospital (1) · Beijing Tsinghua Chang Gung Hospital (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Hospital de Clinicas de Porto Alegre (1) · M.D. Anderson Cancer Center (1) · Mazandaran University of Medical Sciences (1) · National Institutes of Health Clinical Center (CC) (1) · Northwestern University (1) · Tongji Hospital (1) · University of Cincinnati (1) · University of Colorado, Denver (1) · Washington University School of Medicine (1)
United States (7) · China (3) · Brazil (1) · Egypt (1) · Iran (1) · Spain (1) · United Kingdom (1)
Barry S Weinstock, MD (1) · Clive Kearon, MB, MRCP, FRCP(C), PhD (1) · Fakhir Elmasri, MD (1) · Horiana Grosu, M D (1) · Immad Sidiq, MD (1) · Jacob Cynamon, MD (1) · John Gurley, MD (1) · John Rundback, MD (1) · Joseph P. Broderick, MD (1) · Juan Ayerdi, MD (1) · Kannan Natarajan, MD (1) · Keith M Sterling, MD (1) · Marilyn J Manco-Johnson, MD (1) · Mark J Garcia, MD (1)
PMID 19741062, PMID 20047905, PMID 23537968, PMID 26315743, PMID 27913777, PMID 29211671, PMID 30025734, PMID 30586751, PMID 30699446, PMID 31354089, PMID 31592728, PMID 31843251, PMID 33445952, PMID 39968829
2016 (1), U01HL088476 (1)