6 completed, 1 unknown. 7 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 6, Unknown 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow Proguanil: new trials by email Literature Review of Proguanil trials Research Report on Proguanil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Influence of Tegoprazan on the Pharmacokinetics of Proguanil in Healthy Volunteers Atovaquone / Proguanil 250/100 mg, Tegoprazan 50 mg, Esomeprazole 40 mg - Gastroesophageal Reflux Disease | Phase 1 | Completed | Seoul National University Hospital | 19 | 2020-11-25 | 2021-09-27 |
| Safety and Protective Efficacy of IV Immunization With Cryopreserved PfSPZ Under A/P Chemoprophylaxis atovaquone/proguanil 250mg/100mg (A/P), PfSPZ Challenge (NF54), NaCl 0,9% - Malaria | Phase 1 | Completed | University Hospital Tuebingen | 30 | 2016-11-28 | 2019-07-15 |
| Quality of Life Study for Sickle Cell Patients Treated With Jobelyn (Sorghum Bicolor Extract) Folic Acid + Paludrine + Jobelyn (500mg), Folic Acid + Paludrine + Jobelyn (250mg), Folic Acid + Paludrine + Jobelyn (2mg) - Other Sickle-cell Disorders With Crisis, Unspecified | Phase 1 / Phase 2 | Unknown | Lagos State University | 96 | 2013-04-01 | 2013-04-04 |
| Single Oral Dose Study of Atovaquone/Proguanil Hydrochloride Combination Tablets and Atovaquone Suspension Atovaquone/proguanil HCL, Atovaquone - Malaria | Phase 1 | Completed | GlaxoSmithKline | 30 | 2012-04-01 | 2017-03-22 |
| The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia Paludrine + Folic Acid, Paludrine + Folic Acid + Jobelyn - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Lagos State University | 150 | 2012-01-01 | 2012-10-10 |
| Impact of CYP2C19*17 on the Pharmacokinetics of Proguanil and Clopidogrel Proguanil, Clopidogrel - CYP2C19 Genotypes | Phase 1 | Completed | University of Southern Denmark | 31 | 2011-10-01 | 2013-07-03 |
| Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine - Malaria, Sickle Cell Crisis | Phase 1 / Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 270 | 2011-09-01 | 2014-03-21 |
Anemia, Sickle Cell (3) · Malaria (3) · Gastroesophageal Reflux (1) · Vaso-Occlusive Crises (1)
Lagos State University (2) · GlaxoSmithKline (1) · London School of Hygiene and Tropical Medicine (1) · Seoul National University Hospital (1) · University Hospital Tuebingen (1) · University of Southern Denmark (1)
Nigeria (3) · Denmark (1) · Japan (1) · South Korea (1)
A O Dosunmu, M.D. (2) · Kalifa Bojang, PhD (1) · Paul J Milligan, PhD (1) · Peter G Kremsner, Prof (1) · Rasaq Olaosebikan, MD (1) · SeungHwan Lee, MD, PhD (1)