14 completed, 3 recruiting, 3 unknown, 1 available. 11 Phase 4, 3 Phase 2, 2 Not applicable, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 11 | Completed 8, Unknown 2, Recruiting 1 |
| Phase 2 | 3 | Completed 3 |
| Not applicable | 2 | Completed 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
Follow Probucol: new trials by email Literature Review of Probucol trials Research Report on Probucol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Probucol Combined with Statins Treatment for Ischemic Stroke Statin, Probucol - Ischemic Stroke, Atherosclerosis of Artery | Recruiting | Xuanwu Hospital, Beijing | 200 | 2024-10-17 | 2025-03-25 | |
| Probucol for Symptomatic Intracranial and Extracranial Artery Stenosis Probucol, Placebo probucol - Ischemic Stroke, TIA | Phase 3 | Recruiting | First Affiliated Hospital of Wannan Medical College | 5452 | 2024-06-15 | 2024-07-15 |
| The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic Plaques Atorvastatin Calcium, Probucol, PCSK9 inhibitor - Stroke, Ischemic, Atherosclerosis, Cerebral | Phase 4 | Recruiting | General Hospital of Shenyang Military Region | 100 | 2018-12-01 | 2026-04-27 |
| Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration Probucol - Dementia of the Alzheimer Type, Age-related Cognitive Decline | Phase 1 / Phase 2 | Completed | Douglas Mental Health University Institute | 23 | 2016-04-01 | 2018-01-31 |
| To Compare the Effect of Concomitant Administration of Probucol and Cilostazol With Probucol Single Treatment on the Atherosclerosis Related Markers (Including the Thickness of the Achilles Tendon) and Evaluate Safety (Based on Atorvastatin Treatment) in Severe Hypercholesterolemia Subject Atorvastatin, Probucol, Cilostazol - Severe Hypercholesterolemia | Phase 4 | Completed | Otsuka Beijing Research Institute | 300 | 2013-10-01 | 2025-03-27 |
| Efficacy and Safety Study of Probucol in Patients With Diabetic Nephropathy Probucol 250mg/day, Probucol 500mg/day, Placebo - Diabetic Nephropathy | Phase 2 | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 126 | 2012-10-01 | 2017-05-03 |
| Pharmacokinetics and Safety Study of Probucol by Multiple Administration in Healthy Male Subjects Probucol - Healthy | Phase 1 | Completed | Otsuka Beijing Research Institute | 12 | 2012-02-01 | 2013-06-05 |
| Efficacy and Safety of Imported Probucol to Treat Hyperlipidemia Probucol, Placebo - Hyperlipidemia | Phase 3 | Completed | Otsuka Beijing Research Institute | 264 | 2011-04-01 | 2013-06-05 |
| Effect of Probucol and/or Cilostazol on Mean IMT in Patients With Coronary Heart dIsease HMG-CoA Reductase Inhibitor, Probucol, Cilostazol - Hyperlipidemias | Phase 4 | Completed | Seoul National University Hospital | 342 | 2011-03-01 | 2019-09-20 |
| Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety Cilostazol, Probucol - Peripheral Artery Disease | Phase 2 | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 80 | 2010-05-19 | 2022-07-18 |
| A Clinical Study to Evaluate the Efficacy and Safety of Cilostazol and Probucol in Combination on Patients With Diabetic Nephropathy Probucol, Probucol and Cilostazol - Diabetic Nephropathy | Phase 4 | Completed | Otsuka Beijing Research Institute | 353 | 2010-03-01 | 2013-05-08 |
| Synergistic Effect of Combination Therapy With Cilostazol and Probucol on Plaque Stabilization and Lesion Regression: Serial Intravascular Ultrasound and Virtual Histology Study(SECURE Study) Cilostazol, Probucol / placebo of probucol - Therapy | Phase 4 | Completed | Yonsei University | 118 | 2009-11-01 | 2011-06-17 |
| PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study cilostazol, Probucol, Aspirin - Brain Ischemia, Intracranial Hemorrhages | Phase 4 | Unknown | Asan Medical Center | 800 | 2009-06-01 | 2015-12-24 |
| PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Cilostazol, Probucol, Aspirin - Brain Ischemia, Intracranial Hemorrhages | Phase 4 | Unknown | Asan Medical Center | 1600 | 2009-06-01 | 2015-12-24 |
| A Bioequivalence Study Comparing a Single Oral Intake of an Imported PROBUCOL Tablet(Lorelco) With a Marketed PROBUCOL Tablet(Chang Tai) in Chinese Healthy Volunteers Group A: imported Probucol ( Lorelco), Group B: Marketed Probucol ( Chang Tai) - Chinese Healthy Volunteers | Not applicable | Completed | Otsuka Beijing Research Institute | 120 | 2009-03-01 | 2014-07-22 |
| Pharmacokinetics Study for Probucol probucol - Healthy | Phase 4 | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 30 | 2009-02-01 | 2022-03-04 |
| Study of Cilostazol and Probucol to Assess Their Effects on Atherosclerosis Related Biomarker Cilostazol, Probucol, Cilostazol+Probucol - Type 2 Diabetes Mellitus, Arteriosclerosis Obliterans | Phase 4 | Completed | Otsuka Beijing Research Institute | 200 | 2008-10-01 | 2025-03-27 |
| Probucol Combined With Valsartan in Reducing Proteinuria in Diabetes Nephropathy Valsartan, Placebo, Probucol - Type 2 Diabetes Mellitus, Nephropathy | Not applicable | Unknown | Guangdong Provincial People's Hospital | 170 | 2008-05-01 | 2016-08-24 |
| Safety and Pharmacokinetics of Probucol and Cilostazol Cilostazol, Probucol - Healthy | Phase 4 | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 32 | 2007-10-01 | 2022-03-04 |
| A Study of the Antioxidant Probucol Combined With Valsartan in Patients With IgA Nephropathy Valsartan, Probucol, Placebo - Glomerulonephritis, IGA Nephropathy | Phase 4 | Completed | Guangdong Provincial People's Hospital | 75 | 2007-05-01 | 2013-08-28 |
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Ischemic Stroke (5) · Brain Ischemia (2) · Diabetes Mellitus, Type 2 (2) · Diabetic Nephropathies (2) · Hyperlipidemias (2) · Intracranial Hemorrhages (2) · Arteriosclerosis Obliterans (1) · Atherosclerosis (1) · Coronary Artery Disease (1) · Genetic Diseases, Inborn (1) · Glomerulonephritis (1) · Glomerulonephritis, IGA (1) · Hypercholesterolemia (1) · Intracranial Arteriosclerosis (1) · Kidney Diseases (1)
Otsuka Beijing Research Institute (6) · Korea Otsuka Pharmaceutical Co., Ltd. (4) · Asan Medical Center (2) · Guangdong Provincial People's Hospital (2) · Douglas Mental Health University Institute (1) · First Affiliated Hospital of Wannan Medical College (1) · General Hospital of Shenyang Military Region (1) · RiboNova Inc. (1) · Seoul National University Hospital (1) · Xuanwu Hospital, Beijing (1) · Yonsei University (1)
China (12) · South Korea (7) · Canada (1) · Philippines (1) · United States (1)
Byung-Hee Oh, M.D. (1) · Cheol Ho Kim, M.D. (1) · Huisheng Chen, Doctor (1) · In-Jin Jang, PhD (1) · Jie Lin, Dr (1) · Jing Dong, Doctor (1) · John C Breitner, MD, MPH (1) · Kyung-Sang Yoo, MD, PhD (1) · Moo-Hyun Kim, M.D. (1) · MoonKyu Lee, professor (1) · Pei Hu, Dr. (1) · Pei Hu, PHD (1) · Sang-Hyun Kim, M.D. (1) · Shi Wei, MD, PhD (1) · Shuiping Zhao, MD (1)
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