49 completed, 45 active not recruiting, 36 recruiting, 10 withdrawn. 94 Phase 2, 37 Phase 3, 20 Phase 1, 17 Not applicable, 10 Phase 4.
Follow Placebo Administration: new trials by email Literature Review of Placebo Administration trials Research Report on Placebo Administration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Venetoclax or Placebo in Combination With Reduced-Intensity Conditioning Hematopoietic Cell (Bone Marrow/Blood Stem Cell) Transplant and as Maintenance Therapy After Transplant in Patients With Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) Allogeneic Hematopoietic Stem Cell Transplantation, Biospecimen Collection, Bone Marrow Biopsy - Acute Myeloid Leukemia | Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 244 | 2027-01-15 | 2026-10-20 |
| HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Not yet recruiting | Mayo Clinic | 80 | 2026-12-01 | 2026-10-05 |
| Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream Biospecimen Collection, Cannabis sativa Extract, Nicotine - Cannabis Dependence | Early Phase 1 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-10-15 | 2026-09-25 |
| THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia Biospecimen Collection, Placebo Administration, Single Agent Therapy - Insomnia, Malignant Solid Neoplasm | Phase 2 | Not yet recruiting | Mayo Clinic | 69 | 2026-10-01 | 2026-09-02 |
| Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia Best Practice, Biospecimen Collection, Cytarabine - Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia | Phase 3 | Recruiting | Children's Oncology Group | 556 | 2026-08-14 | 2026-09-04 |
| Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis Placebo Administration, Alpha-Lipoic Acid 200 mg, Alpha-Lipoic Acid 600 mg - Gingivitis and Periodontal Diseases | Not applicable | Recruiting | Biruni University | 80 | 2026-08-05 | 2026-10-20 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction Combined dexmedetomidine-esketamine administration, Placebo administration - Ureteral Stricture, Dexmedetomidine | Phase 4 | Not yet recruiting | Peking University First Hospital | 658 | 2026-08-01 | 2026-08-14 |
| Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis Synbiotic supplementation, Placebo Administration - Periodontal Disease | Not applicable | Not yet recruiting | Biruni University | 92 | 2026-07-06 | 2026-06-26 |
| Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer Intensity-Modulated Radiation Therapy, Volume Modulated Arc Therapy, Pencil Beam Scanning - Astrocytoma, IDH-Mutant, Grade 3 | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 408 | 2026-06-24 | 2026-10-02 |
| Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus Biopsy Procedure, Biospecimen Collection, Endoscopic Procedure - Barrett Esophagus, Clinical Stage I Esophageal Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 76 | 2026-06-23 | 2026-09-14 |
| Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer Axitinib, Biospecimen Collection, Bone Scan - Advanced Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 718 | 2026-06-05 | 2026-06-11 |
| Axatilimab Plus Standard of Care Therapy for the Prevention of Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Cancer, ABRAXAS Trial Allogeneic Hematopoietic Stem Cell Transplantation, Axatilimab, Biospecimen Collection - Hematopoietic and Lymphatic System Neoplasm | Phase 2 | Withdrawn | Mayo Clinic | 2026-06-01 | 2026-09-03 | |
| Effects of Repletion of Sodium Chloride on Natriuresis, Blood Pressure, and Neurohormonal Activity in Patients With Chronic Heart Failure With Reduced Ejection Fraction Sodium chloride supplementation, Placebo administration - Chronic Heart Failure With Reduced Ejection Fraction | Not applicable | Not yet recruiting | Wroclaw Medical University | 30 | 2026-05-01 | 2026-05-29 |
| Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy Biospecimen Collection, Capecitabine, Diltiazem Hydrochloride - Malignant Digestive System Neoplasm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-04-30 | 2026-06-02 |
| Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-16 |
| Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-14 |
| Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy Biospecimen Collection, Placebo Administration, Probiotic - Advanced Ovarian Carcinoma, Recurrent Ovarian Carcinoma | Early Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 161 | 2026-03-06 | 2026-08-17 |
| Sulforaphane for the Prevention of Melanoma in Patients With Multiple Atypical Nevi and a Prior History of Melanoma Biopsy Procedure, Biospecimen Collection, Placebo Administration - Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8 | Phase 2 | Recruiting | ECOG-ACRIN Cancer Research Group | 120 | 2026-02-20 | 2026-09-15 |
| Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells Axicabtagene Ciloleucel, Biospecimen Collection, Chemotherapy - Recurrent Diffuse Large B-Cell Lymphoma, Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements | Phase 2 | Recruiting | City of Hope Medical Center | 56 | 2026-02-11 | 2026-03-05 |
| Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors Biospecimen Collection, Cannabidiol, Dronabinol - Breast Carcinoma, Chemotherapy-Induced Peripheral Neuropathy | Phase 2 | Recruiting | City of Hope Medical Center | 120 | 2025-10-03 | 2025-12-05 |
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Breast Neoplasms (12) · Hematologic Neoplasms (11) · Colorectal Neoplasms (7) · Pain (7) · Prostatic Neoplasms (7) · Glioblastoma (5) · Leukemia, Myeloid, Acute (5) · Lung Neoplasms (5) · Neoplasms (5) · Hodgkin Disease (4) · Myelodysplastic Syndromes (4) · Adenocarcinoma Of Esophagus (3) · Barrett Esophagus (3) · Breast Carcinoma In Situ (3) · COVID-19 (3)
National Cancer Institute (NCI) (56) · Mayo Clinic (13) · M.D. Anderson Cancer Center (8) · City of Hope Medical Center (7) · Academic and Community Cancer Research United (4) · Alliance for Clinical Trials in Oncology (4) · Children's Oncology Group (4) · ECOG-ACRIN Cancer Research Group (4) · Jonsson Comprehensive Cancer Center (4) · OHSU Knight Cancer Institute (4) · Fred Hutchinson Cancer Center (3) · John Paul II Hospital, Krakow (3) · NRG Oncology (3) · Northwestern University (3) · Ohio State University Comprehensive Cancer Center (3)
United States (135) · Canada (16) · Puerto Rico (16) · China (4) · France (4) · Poland (4) · Italy (3) · South Korea (3) · Guam (2) · Israel (2) · South Africa (2) · Spain (2) · Turkey (Türkiye) (2) · Australia (1) · Austria (1)
Sriram Yennu (3) · Charles L Loprinzi (2) · Dong-Xin Wang (2) · Eduardo Vilar-Sanchez (2) · Marc T Goodman (2) · Stacy D. D'Andre, MD (2) · York E Miller (2) · Ajay Bansal (1) · Ajay Bansal, MD (1) · Al B Benson (1) · Alan L Ho (1) · Alexander N Shoushtari (1) · Alicia K Morgans (1) · Aminah Jatoi, M.D. (1)
PMID 15217656, PMID 16243241, PMID 18772216, PMID 20224951, PMID 21602018, PMID 21669954, PMID 21982727, PMID 22293631, PMID 22571201, PMID 22857721, PMID 2457102, PMID 25348000, PMID 25683094, PMID 25732163, PMID 26615020, PMID 27716152, PMID 28646344, PMID 28826616, PMID 29906251, PMID 29948566, PMID 30040523, PMID 30054636, PMID 30197041, PMID 30575484, PMID 30977845, PMID 31386610, PMID 31401903, PMID 3156545, PMID 31924662, PMID 32154928, PMID 32641470, PMID 33152282, PMID 33258687, PMID 33347618, PMID 33485453, PMID 33989025, PMID 34357781, PMID 34420143, PMID 34636255, PMID 34726788, PMID 34843839, PMID 35226083, PMID 35297944, PMID 35448895, PMID 36184621, PMID 36623515, PMID 36681089, PMID 36902217, PMID 36951827, PMID 36972022
U10CA180821 (16), P30CA060553 (10), U10CA031946 (10), P30CA033572 (8), U10CA180820 (8), U10CA180868 (8), N01CN00035 (6), P30CA015083 (6), U10CA180830 (6), P30CA023074 (5), U10CA180888 (5), P30CA016672 (4), U10CA021115 (4), UG1CA189955 (4), UG1CA242596 (4)