8 completed, 5 unknown, 2 active not recruiting, 2 not yet recruiting. 11 Not applicable, 3 Phase 4, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 4, Active not recruiting 2, Not yet recruiting 2, Unknown 2, Recruiting 1 |
| Phase 4 | 3 | Unknown 2, Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Pit and Fissure Sealants: new trials by email Literature Review of Pit and Fissure Sealants trials Research Report on Pit and Fissure Sealants
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Wear Resistance Of Bioactive With And Without Etching Vs. Conventional Resin-Based Fissure Sealants Bioactive Sealant with Etching: Participants in this group received a fluoride-releasing bioactive pit and fissure sealant (BeautiSealant, Shofu) applied after etching the tooth surface with 37% phosp, Bioactive Sealant without Etching: In this group, the same bioactive sealant (BeautiSealant, Shofu) was applied directly without acid etching. This simplified technique evaluates the sealant's effecti, Conventional Resin-Based Sealant with Etching (Control): This group received a conventional resin-based sealant (Fisseal, Promedica) following standard acid etching. This technique represents the trad - Pit and Fissure Caries | Not applicable | Not yet recruiting | Cairo University | 23 | 2025-08-01 | 2025-06-12 |
| Clinical Performance of Giomer Preceded by Etching Versus Resin-Based Sealants Applied on Permanent Molars Affected by Molar-Incisor Hypo-mineralization Giomer pit and fissure sealant with etching applied on Permanent Molars Affected by MIH, Resin based sealant applied on Permanent Molars Affected by MIH - Molar Incisor Hypomineralization | Not applicable | Not yet recruiting | Cairo University | 56 | 2025-06-01 | 2025-04-16 |
| Evaluation of the Clinical Success of Hydrophilic Fissure Sealants pit and fissure sealant - Pit and Fissure Caries (Disorder), Pit and Fissure Sealants | Not applicable | Active not recruiting | Afyonkarahisar Health Sciences University | 250 | 2025-03-01 | 2025-12-03 |
| Dry-Shield vs Rubber Dam During Fissure Sealant Placement Pit and fissure sealant (Conseal F) - Pit and Fissure Sealants, Dental Caries Prevention | Not applicable | Completed | Suez Canal University | 30 | 2025-02-26 | 2026-06-03 |
| The Effect of an Adhesive System on the Retention and Caries Prevention for Fissure Sealants in Permanent Molars Fissure sealant without adhesive system (NO BOND), Fissure sealant with adhesive system (BOND) - Dental Caries, Fissure Sealant | Not applicable | Active not recruiting | University of Dublin, Trinity College | 100 | 2024-06-05 | 2026-09-15 |
| Dental Isolation Systems Among Pediatric Patients With Different Airway Patency Rubber Dam Isolation, DryShieled isolation, fissure sealant - Airway Obstruction, Pain | Not applicable | Unknown | King Abdulaziz University | 60 | 2023-11-15 | 2023-11-13 |
| Effectiveness and Retention of Pit and Fissure Sealants in Rural Setup: A School-based Clinical Trial in Nepal Glass Ionomer cement pit and fissure sealant, Silver Diamine Fluoride - Dental Caries Pit and Fissure, Oral Disease | Unknown | Kathmandu University School of Medical Sciences | 377 | 2023-08-10 | 2023-06-08 | |
| Clinical Evaluation of Pit and Fissure Sealants Biocoat Pit and fissure sealant, Fissurit FX Pit and fissure sealant - Pit and Fissure Sealants | Completed | Canan Bayraktar Nahir | 63 | 2023-08-01 | 2025-05-23 | |
| Retention Rate of Giomer Pit and Fissure Sealant Applied With or Without Etching Giomer pit and fissure sealant without etching, Giomer pit and fissure sealant with etching - Caries Prevention | Phase 4 | Unknown | Cairo University | 52 | 2023-05-01 | 2024-07-30 |
| Retention Rate and Caries Preventive Effect of Preheated Flowable Resin Composite Used as a Pit and Fissure Sealant Pre-heating of flowable resin composite used as a pit and fissure sealant., Conventional resin fissure sealant - Pit and Fissure Sealant | Not applicable | Completed | Cairo University | 28 | 2022-11-20 | 2024-05-14 |
| "Comparative Clinical Evaluation of Pit and Fissure Sealants on Permanent First Molar Teeth in Children." Sealant, Fissure - PITS AND FISSURE SEALANT | Phase 3 | Completed | Postgraduate Institute of Dental Sciences Rohtak | 42 | 2021-04-02 | 2023-03-30 |
| Two Preventive Measures on Caries Progression in Mixed Dentition Patients. SDF1, Diode Laser, Pit Fissure Sealant - Dentist's Role | Phase 2 | Completed | British University In Egypt | 23 | 2020-06-01 | 2023-11-07 |
| Ozone Application Before Fissure Sealants Ozone, Pits and fissure sealants - Caries,Dental | Not applicable | Recruiting | IRCCS Burlo Garofolo | 67 | 2019-06-17 | 2025-05-16 |
| Investigation of the Incidence of Caries in Pits and Fissures Sealed With Bioactive Sealant Compared to Fluoride Releasing Resin Based Pit and Fissure Sealant Embrace™ WetBond™ Pit & Fissure Sealant, Seal-Rite™ Pit & Fissure Sealant, Pulpdent Corportation, USA - Pit and Fissure Caries | Not applicable | Unknown | Cairo University | 80 | 2018-08-01 | 2018-08-16 |
| Occlusal Caries Management in First Permanent Molars in Child Dental Care Fluoride Varnishes, Fissure Sealants - Dental Caries Pit and Fissure, Dental Caries in Children | Phase 4 | Unknown | Oral Health Centre of Expertise in Eastern Norway | 410 | 2017-02-01 | 2023-10-31 |
| Efficacy of Sealants in Cavitated Enamel Lesions on Occlusal Surfaces in Children fissure sealant, oral hygiene orientation - Fissure Sealants, Oral Hygiene Orientation | Not applicable | Completed | Faculty Sao Leopoldo Mandic Campinas | 546 | 2015-05-01 | 2017-05-05 |
| Use of Fissure Sealants on Primary Molars Fissure sealant, Fissure sealants and fluoride varnish - Dental Caries | Phase 4 | Completed | Kuwait University | 148 | 2011-10-01 | 2014-03-18 |
| Effectiveness of Pit and Fissure Sealants in the Prevention of Dental Caries pit and fissure sealant - Caries, Dental | Not applicable | Completed | Centre Hospitalier Universitaire de Nice | 400 | 2004-12-01 | 2012-02-22 |
Van der Woude syndrome (7) · Dental Caries (5) · Airway Obstruction (1) · Behavior (1) · Molar Hypomineralization (1) · Mouth Diseases (1) · Pain (1)
Cairo University (5) · Afyonkarahisar Health Sciences University (1) · British University In Egypt (1) · Canan Bayraktar Nahir (1) · Centre Hospitalier Universitaire de Nice (1) · Faculty Sao Leopoldo Mandic Campinas (1) · IRCCS Burlo Garofolo (1) · Kathmandu University School of Medical Sciences (1) · King Abdulaziz University (1) · Kuwait University (1) · Oral Health Centre of Expertise in Eastern Norway (1) · Postgraduate Institute of Dental Sciences Rohtak (1) · Suez Canal University (1) · University of Dublin, Trinity College (1)
Egypt (5) · Turkey (Türkiye) (2) · Brazil (1) · France (1) · India (1) · Ireland (1) · Italy (1) · Kuwait (1) · Nepal (1) · Norway (1) · Saudi Arabia (1)
Basma Gamal, Lecturer (1) · Dashrath Kafle, MDS (1) · Eman Abouauf, Ass.prof (1) · Jose CP Imparato, PhD (1) · Maddalena Chermetz, DDS,MSc (1) · Milena Cadenaro, DDS,MSc,PhD (1) · Noha Kabil, Professor (1) · Rona Leith (1) · Sara M Bagher, Mater (1) · Sisko L Honkala, DDS, PhD (1)
PMID 18310730, PMID 23636296, PMID 27557916, PMID 30328064, PMID 31631242, PMID 32165964, PMID 33653594, PMID 33976497, PMID 34110615, PMID 34506432, PMID 34669177, PMID 35215692, PMID 35568765, PMID 38442802, PMID 39136874, PMID 39511504, PMID 42823705