16 completed, 7 recruiting, 2 unknown, 1 active not recruiting. 8 Phase 3, 5 Phase 2, 5 Phase 4, 3 Not applicable, 2 Phase 1.
Follow Piperacillin-tazobactam: new trials by email Literature Review of Piperacillin-tazobactam trials Research Report on Piperacillin-tazobactam
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings Piperacillin-tazobactam - Hepatobiliary Surgery, Prophylactic Antibiotics | Not applicable | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 378 | 2026-05-24 | 2026-06-02 |
| Aminoglycosides in Early Sepsis Gentamicin + narrow spectrum betalactam, Cefotaxime, Piperacillin-tazobactam - Sepsis | Phase 4 | Recruiting | University Hospital, Akershus | 1900 | 2026-04-23 | 2026-10-28 |
| Continuous Antibiotic Infusion In Children Benzylpenicillin - Infection | Phase 3 | Recruiting | Tampere University Hospital | 150 | 2026-04-21 | 2026-05-08 |
| A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients Vancomycin, Piperacillin-tazobactam, Cefepime - Acute Kidney Injury | Phase 4 | Recruiting | University of Pennsylvania | 750 | 2026-01-28 | 2026-02-13 |
| Precision Dosing of Beta-lactam Antibiotics in Critically Ill Children Beta-lactam antibiotic, Beta-lactam model-informed precision dosing - Amoxicillin-clavulanate, Piperacillin-tazobactam | Phase 4 | Recruiting | University Hospital, Ghent | 58 | 2025-07-09 | 2026-09-17 |
| Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers. Piperacillin-tazobactam - Enterobacteriaceae Infections | Not applicable | Completed | University Hospital, Bordeaux | 9 | 2022-02-16 | 2026-05-19 |
| PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN Imipenem/Cilastatin/Relebactam, Cefepime, Meropenem - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 2 | Completed | M.D. Anderson Cancer Center | 100 | 2021-09-14 | 2026-04-06 |
| Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics Best Practice, Fecal Microbiota Transplantation, Nystatin - Graft-versus-host Disease Prevention | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2020-06-01 | 2020-03-04 | |
| Pharmacokinetics of Antibiotics During Extracorporeal Membrane Oxygenation (ECMO) Support piperacillin-tazobactam, Cefazolin - Drug Effect | Terminated | Boston Children's Hospital | 4 | 2019-08-27 | 2022-03-21 | |
| Comparative Study To Determine The Efficacy, Safety, And Tolerability Of Ceftolozane-Tazobactam Cefepime, Ceftolozane, Laboratory Biomarker Analysis - Other Infectious Diseases | Phase 2 | Completed | M.D. Anderson Cancer Center | 100 | 2018-05-16 | 2022-03-15 |
| Amplification and Selection of Antimicrobial Resistance in the Intestine II meropenem - Antibiotic Selection Pressure | Completed | University Hospital Tuebingen | 60 | 2018-01-30 | 2020-08-03 | |
| Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy? Cefoxitin, Piperacillin-tazobactam - Pancreatic Cancer, Pancreas Cancer | Phase 3 | Completed | Memorial Sloan Kettering Cancer Center | 967 | 2017-11-21 | 2025-10-21 |
| Two Different Antibiotics Versus One Antibiotic for Pediatric Perforated Appendicitis Piperacillin, Tazobactam Drug Combination - Perforated Appendicitis, Postoperative Infection | Phase 4 | Completed | Phoenix Children's Hospital | 162 | 2017-05-22 | 2024-01-12 |
| Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant Piperacillin-tazobactam, cefepime - Intestinal Microbiome, Febrile Neutropenia | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 347 | 2017-02-10 | 2026-03-04 |
| Target Attainment and Pharmacokinetics of Antimicrobials in Non-critically Ill Surgery Patients (TAPAS) amoxicillin-clavulanic acid - Surgery | Unknown | Universitaire Ziekenhuizen KU Leuven | 120 | 2016-11-30 | 2017-04-20 | |
| PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock MEROPENEM, PIPERACILLIN-TAZOBACTAM, CEFEPIME - Septic Shock | Phase 3 | Completed | Centre Hospitalier Universitaire de Besancon | 119 | 2016-09-27 | 2025-01-16 |
| Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem - Pharmacokinetics, Amoxicillin-clavulanate | Not applicable | Recruiting | University Hospital, Ghent | 300 | 2016-08-19 | 2026-09-21 |
| Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam - Community-acquired Pneumonia, Influenza, COVID-19 | Phase 3 | Recruiting | UMC Utrecht | 20000 | 2016-04-11 | 2024-07-12 |
| Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections ZTI-01, Piperacillin-tazobactam - Urinary Tract Infection Symptomatic, Acute Pyelonephritis | Phase 2 / Phase 3 | Completed | Nabriva Therapeutics AG | 465 | 2016-04-01 | 2019-03-07 |
| Safety and Pharmacokinetics of Piperacillin-tazobactam Extended Infusion in Infants and Children (PIP-TAZO) Piperacillin-tazobactam - Infection | Phase 1 | Unknown | St. Justine's Hospital | 141 | 2016-01-01 | 2018-04-19 |
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Sepsis (5) · Infections (4) · Hematologic Neoplasms (2) · Influenza, Human (2) · Leukemia (2) · Lymphoma (2) · Neoplasms, Plasma Cell (2) · Pneumonia (2) · Shock, Septic (2) · Acute Kidney Injury (1) · Adenoviridae Infections (1) · Anemia, Refractory, with Excess of Blasts (1) · Anxiety Disorders (1) · Appendicitis (1) · Arrhythmias, Cardiac (1)
M.D. Anderson Cancer Center (3) · Memorial Sloan Kettering Cancer Center (2) · University Hospital, Ghent (2) · Wyeth is now a wholly owned subsidiary of Pfizer (2) · Boston Children's Hospital (1) · Centre Hospitalier Universitaire de Besancon (1) · Daniel Benjamin (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Karolinska Institutet (1) · Melinta Therapeutics, Inc. (1) · Nabriva Therapeutics AG (1) · Phillip Brian Smith (1) · Phoenix Children's Hospital (1) · St. Justine's Hospital (1) · Sutep Jaruratanasirikul (1)
United States (14) · Belgium (5) · Canada (5) · Czechia (4) · France (4) · Finland (3) · Germany (3) · Greece (3) · Hungary (3) · Israel (3) · Romania (3) · Slovakia (3) · Spain (3) · United Kingdom (3) · Belarus (2)
Issam I Raad (2) · Amin M Alousi (1) · Annick de Jaeger, MD (1) · Chi Hornik, PharmD (1) · Colin McArthur, Dr (1) · Derek Angus, Prof (1) · Evelyn Dhont, Dr. (1) · Evelyn J Ellis-Grosse, PhD (1) · Folke Hammarqvist, Ass Prof (1) · John Marshall, Prof (1) · Julie Autmizguine, MD, MHS (1) · Justin Lee, MD (1) · Karen Fusaro (1) · Keith Kaye (1)
PMID 15327406, PMID 20350927, PMID 20458318, PMID 20594297, PMID 22569355, PMID 24614374, PMID 24949994, PMID 26039810, PMID 26926644, PMID 27522443, PMID 28101605, PMID 28137820, PMID 28290120, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29486041, PMID 29677389, PMID 29937192, PMID 30790601, PMID 30861061, PMID 31317556, PMID 31548185, PMID 31814149, PMID 31833540, PMID 32011685, PMID 32222460, PMID 32267771, PMID 32324313, PMID 32497307, PMID 32860109, PMID 32876697, PMID 33029806, PMID 33394942, PMID 33509275, PMID 33631065, PMID 33664081, PMID 33903114, PMID 34251506, PMID 34302290, PMID 34351721, PMID 34351722, PMID 34473343, PMID 34606578, PMID 34768176, PMID 35315874, PMID 35370711, PMID 35491971, PMID 35663286
2015 (2), 2023 (1), 2025 (1), P30CA016672 (1)